GPR42_HUMAN
ID GPR42_HUMAN Reviewed; 346 AA.
AC O15529;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=G-protein coupled receptor 42;
GN Name=GPR42; Synonyms=GPR42P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9344866; DOI=10.1006/bbrc.1997.7513;
RA Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr.,
RA O'Dowd B.F.;
RT "A cluster of four novel human G protein-coupled receptor genes occurring
RT in close proximity to CD22 gene on chromosome 19q13.1.";
RL Biochem. Biophys. Res. Commun. 239:543-547(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP CHARACTERIZATION OF VARIANT ARG-174.
RX PubMed=12496283; DOI=10.1074/jbc.m211609200;
RA Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L.,
RA Daniels D., Muir A.I., Wigglesworth M.J., Kinghorn I., Fraser N.J.,
RA Pike N.B., Strum J.C., Steplewski K.M., Murdock P.R., Holder J.C.,
RA Marshall F.H., Szekeres P.G., Wilson S., Ignar D.M., Foord S.M., Wise A.,
RA Dowell S.J.;
RT "The orphan G protein-coupled receptors GPR41 and GPR43 are activated by
RT propionate and other short chain carboxylic acids.";
RL J. Biol. Chem. 278:11312-11319(2003).
RN [4]
RP IDENTIFICATION AS A FUNCTIONAL GENE, FUNCTION, POLYMORPHISM, AND VARIANTS
RP GLN-44; ARG-45; ARG-174; LEU-227; ALA-256 AND SER-346.
RX PubMed=19630535; DOI=10.1089/dna.2009.0916;
RA Liaw C.W., Connolly D.T.;
RT "Sequence polymorphisms provide a common consensus sequence for GPR41 and
RT GPR42.";
RL DNA Cell Biol. 28:555-560(2009).
CC -!- FUNCTION: Probable G protein-coupled receptor that may be activated by
CC a major product of dietary fiber digestion, the short chain fatty acids
CC (SCFAs), and that may play a role in the regulation of whole-body
CC energy homeostasis and/or in intestinal immunity.
CC {ECO:0000269|PubMed:19630535}.
CC -!- INTERACTION:
CC O15529; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-18076404, EBI-10827839;
CC O15529; P20292: ALOX5AP; NbExp=3; IntAct=EBI-18076404, EBI-3904621;
CC O15529; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18076404, EBI-12109402;
CC O15529; P05090: APOD; NbExp=3; IntAct=EBI-18076404, EBI-715495;
CC O15529; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-18076404, EBI-12069500;
CC O15529; P51164: ATP4B; NbExp=3; IntAct=EBI-18076404, EBI-3904463;
CC O15529; Q99437: ATP6V0B; NbExp=3; IntAct=EBI-18076404, EBI-3904417;
CC O15529; P27449: ATP6V0C; NbExp=3; IntAct=EBI-18076404, EBI-721179;
CC O15529; Q12983: BNIP3; NbExp=3; IntAct=EBI-18076404, EBI-749464;
CC O15529; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-18076404, EBI-8648738;
CC O15529; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18076404, EBI-9083477;
CC O15529; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-18076404, EBI-10271156;
CC O15529; Q08708: CD300C; NbExp=3; IntAct=EBI-18076404, EBI-3915344;
CC O15529; P11912: CD79A; NbExp=3; IntAct=EBI-18076404, EBI-7797864;
CC O15529; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-18076404, EBI-11749983;
CC O15529; P21964: COMT; NbExp=3; IntAct=EBI-18076404, EBI-372265;
CC O15529; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-18076404, EBI-12019274;
CC O15529; Q07325: CXCL9; NbExp=3; IntAct=EBI-18076404, EBI-3911467;
CC O15529; Q8N682: DRAM1; NbExp=3; IntAct=EBI-18076404, EBI-10305400;
CC O15529; P52803: EFNA5; NbExp=3; IntAct=EBI-18076404, EBI-1753674;
CC O15529; P54849: EMP1; NbExp=3; IntAct=EBI-18076404, EBI-4319440;
CC O15529; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-18076404, EBI-10976398;
CC O15529; Q92520: FAM3C; NbExp=3; IntAct=EBI-18076404, EBI-2876774;
CC O15529; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-18076404, EBI-12175685;
CC O15529; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-18076404, EBI-713304;
CC O15529; P29033: GJB2; NbExp=3; IntAct=EBI-18076404, EBI-3905204;
CC O15529; O14653: GOSR2; NbExp=3; IntAct=EBI-18076404, EBI-4401517;
CC O15529; O60883: GPR37L1; NbExp=3; IntAct=EBI-18076404, EBI-2927498;
CC O15529; P04921: GYPC; NbExp=3; IntAct=EBI-18076404, EBI-7797098;
CC O15529; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-18076404, EBI-725665;
CC O15529; P24593: IGFBP5; NbExp=3; IntAct=EBI-18076404, EBI-720480;
CC O15529; Q01638-2: IL1RL1; NbExp=3; IntAct=EBI-18076404, EBI-12838366;
CC O15529; P11215: ITGAM; NbExp=3; IntAct=EBI-18076404, EBI-2568251;
CC O15529; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-18076404, EBI-465137;
CC O15529; Q09470: KCNA1; NbExp=3; IntAct=EBI-18076404, EBI-8286599;
CC O15529; Q96E93: KLRG1; NbExp=3; IntAct=EBI-18076404, EBI-750770;
CC O15529; O43561-2: LAT; NbExp=3; IntAct=EBI-18076404, EBI-8070286;
CC O15529; O95214: LEPROTL1; NbExp=3; IntAct=EBI-18076404, EBI-750776;
CC O15529; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-18076404, EBI-2820517;
CC O15529; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-18076404, EBI-12133176;
CC O15529; Q16873: LTC4S; NbExp=3; IntAct=EBI-18076404, EBI-12241118;
CC O15529; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18076404, EBI-3920969;
CC O15529; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-18076404, EBI-2858252;
CC O15529; O43451: MGAM; NbExp=3; IntAct=EBI-18076404, EBI-2829774;
CC O15529; P11836: MS4A1; NbExp=3; IntAct=EBI-18076404, EBI-2808234;
CC O15529; Q9NX14: NDUFB11; NbExp=3; IntAct=EBI-18076404, EBI-1246182;
CC O15529; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-18076404, EBI-10317425;
CC O15529; Q8IXM6: NRM; NbExp=3; IntAct=EBI-18076404, EBI-10262547;
CC O15529; P42857: NSG1; NbExp=3; IntAct=EBI-18076404, EBI-6380741;
CC O15529; P09466: PAEP; NbExp=3; IntAct=EBI-18076404, EBI-465167;
CC O15529; P60201-2: PLP1; NbExp=3; IntAct=EBI-18076404, EBI-12188331;
CC O15529; O14494: PLPP1; NbExp=3; IntAct=EBI-18076404, EBI-2865290;
CC O15529; Q01453: PMP22; NbExp=3; IntAct=EBI-18076404, EBI-2845982;
CC O15529; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-18076404, EBI-8652812;
CC O15529; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18076404, EBI-1052363;
CC O15529; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18076404, EBI-10244780;
CC O15529; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-18076404, EBI-8636004;
CC O15529; O00767: SCD; NbExp=3; IntAct=EBI-18076404, EBI-2684237;
CC O15529; Q9NRX5: SERINC1; NbExp=3; IntAct=EBI-18076404, EBI-2683145;
CC O15529; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-18076404, EBI-749270;
CC O15529; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-18076404, EBI-17284533;
CC O15529; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18076404, EBI-8644112;
CC O15529; Q99726: SLC30A3; NbExp=3; IntAct=EBI-18076404, EBI-10294651;
CC O15529; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-18076404, EBI-10262251;
CC O15529; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-18076404, EBI-12867720;
CC O15529; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-18076404, EBI-9978441;
CC O15529; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-18076404, EBI-10314552;
CC O15529; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-18076404, EBI-12898013;
CC O15529; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-18076404, EBI-12266234;
CC O15529; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-18076404, EBI-10290130;
CC O15529; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-18076404, EBI-8640191;
CC O15529; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-18076404, EBI-741850;
CC O15529; P02808: STATH; NbExp=3; IntAct=EBI-18076404, EBI-738687;
CC O15529; P0DN84: STRIT1; NbExp=3; IntAct=EBI-18076404, EBI-12200293;
CC O15529; Q9UNK0: STX8; NbExp=3; IntAct=EBI-18076404, EBI-727240;
CC O15529; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-18076404, EBI-726331;
CC O15529; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-18076404, EBI-12187159;
CC O15529; Q9Y6I9: TEX264; NbExp=3; IntAct=EBI-18076404, EBI-10329860;
CC O15529; P02787: TF; NbExp=3; IntAct=EBI-18076404, EBI-714319;
CC O15529; P48230: TM4SF4; NbExp=3; IntAct=EBI-18076404, EBI-8650934;
CC O15529; P55061: TMBIM6; NbExp=3; IntAct=EBI-18076404, EBI-1045825;
CC O15529; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-18076404, EBI-2844246;
CC O15529; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-18076404, EBI-348587;
CC O15529; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-18076404, EBI-10255122;
CC O15529; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-18076404, EBI-741829;
CC O15529; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-18076404, EBI-10982110;
CC O15529; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-18076404, EBI-11528917;
CC O15529; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-18076404, EBI-10315004;
CC O15529; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-18076404, EBI-17180389;
CC O15529; Q3MIR4: TMEM30B; NbExp=3; IntAct=EBI-18076404, EBI-9527107;
CC O15529; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-18076404, EBI-2852148;
CC O15529; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-18076404, EBI-6656213;
CC O15529; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-18076404, EBI-16746122;
CC O15529; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-18076404, EBI-12195249;
CC O15529; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-18076404, EBI-11988865;
CC O15529; O95070: YIF1A; NbExp=3; IntAct=EBI-18076404, EBI-2799703;
CC O15529; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-18076404, EBI-7850136;
CC O15529; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-18076404, EBI-751204;
CC O15529; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-18076404, EBI-751253;
CC O15529; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-18076404, EBI-751210;
CC O15529; O95159: ZFPL1; NbExp=3; IntAct=EBI-18076404, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- POLYMORPHISM: Was originally thought to be a pseudogene due to the
CC presence of a Trp at position 174 which prevents activation by short
CC chain fatty acids, such as propionate (PubMed:12496283). However, the
CC inactivating Trp-174 that differentiate GPR42 from the homologous
CC functional G-protein-coupled receptor FFAR3 is most probably
CC polymorphic for both genes in the human population. The frequency of
CC the active allele of GPR42, with Arg at position 174, is estimated to
CC 61%. Moreover, the 5 other amino acid differences at positions 44, 45,
CC 227, 256 and 346 between GPR42 and FFAR3, are also polymorphic in the
CC human population (PubMed:19630535). {ECO:0000269|PubMed:12496283,
CC ECO:0000269|PubMed:19630535}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF024689; AAB86712.1; -; Genomic_DNA.
DR EMBL; AC002511; AAB67885.1; -; Genomic_DNA.
DR PIR; JC5716; JC5716.
DR RefSeq; NP_001335124.1; NM_001348195.1.
DR AlphaFoldDB; O15529; -.
DR SMR; O15529; -.
DR IntAct; O15529; 101.
DR STRING; 9606.ENSP00000473212; -.
DR GlyGen; O15529; 1 site.
DR BioMuta; GPR42; -.
DR PaxDb; O15529; -.
DR PeptideAtlas; O15529; -.
DR PRIDE; O15529; -.
DR Antibodypedia; 71522; 13 antibodies from 9 providers.
DR DNASU; 2866; -.
DR Ensembl; ENST00000454971.3; ENSP00000410925.1; ENSG00000126251.7.
DR Ensembl; ENST00000597214.1; ENSP00000473212.1; ENSG00000126251.7.
DR GeneID; 2866; -.
DR KEGG; hsa:2866; -.
DR MANE-Select; ENST00000454971.3; ENSP00000410925.1; NM_001348195.2; NP_001335124.1.
DR UCSC; uc021usn.2; human.
DR CTD; 2866; -.
DR DisGeNET; 2866; -.
DR GeneCards; GPR42; -.
DR HGNC; HGNC:4500; GPR42.
DR HPA; ENSG00000126251; Not detected.
DR MIM; 603822; gene.
DR neXtProt; NX_O15529; -.
DR OpenTargets; ENSG00000126251; -.
DR VEuPathDB; HostDB:ENSG00000126251; -.
DR eggNOG; ENOG502QQGM; Eukaryota.
DR GeneTree; ENSGT00990000203527; -.
DR HOGENOM; CLU_009579_8_4_1; -.
DR InParanoid; O15529; -.
DR OMA; PADDISC; -.
DR OrthoDB; 1129026at2759; -.
DR PhylomeDB; O15529; -.
DR TreeFam; TF350010; -.
DR PathwayCommons; O15529; -.
DR SignaLink; O15529; -.
DR BioGRID-ORCS; 2866; 0 hits in 40 CRISPR screens.
DR GenomeRNAi; 2866; -.
DR Pharos; O15529; Tdark.
DR PRO; PR:O15529; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O15529; protein.
DR Bgee; ENSG00000126251; Expressed in blood and 34 other tissues.
DR ExpressionAtlas; O15529; baseline and differential.
DR Genevisible; O15529; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; NAS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR013312; GPR40-rel_orph.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01904; GPR40FAMILY.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..346
FT /note="G-protein coupled receptor 42"
FT /id="PRO_0000069570"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..47
FT /note="Cytoplasmic"
FT TRANSMEM 48..68
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 307..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 44
FT /note="R -> Q (in dbSNP:rs878906072)"
FT /evidence="ECO:0000269|PubMed:19630535"
FT /id="VAR_062860"
FT VARIANT 45
FT /note="C -> R (in dbSNP:rs423385)"
FT /evidence="ECO:0000269|PubMed:19630535"
FT /id="VAR_033468"
FT VARIANT 174
FT /note="W -> R (restores responses to propionate;
FT dbSNP:rs424241)"
FT /evidence="ECO:0000269|PubMed:12496283,
FT ECO:0000269|PubMed:19630535"
FT /id="VAR_062861"
FT VARIANT 227
FT /note="V -> L (in dbSNP:rs403989)"
FT /evidence="ECO:0000269|PubMed:19630535"
FT /id="VAR_033469"
FT VARIANT 256
FT /note="V -> A (in dbSNP:rs424715)"
FT /evidence="ECO:0000269|PubMed:19630535"
FT /id="VAR_033470"
FT VARIANT 346
FT /note="N -> S (in dbSNP:rs381478)"
FT /evidence="ECO:0000269|PubMed:19630535"
FT /id="VAR_062862"
SQ SEQUENCE 346 AA; 38695 MW; 03F6742DA4B798D0 CRC64;
MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS
DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP
LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFWKDQLAI
LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP
YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN
