GPR45_HUMAN
ID GPR45_HUMAN Reviewed; 372 AA.
AC Q9Y5Y3; Q6NWS4; Q6NXU6;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Probable G-protein coupled receptor 45;
DE AltName: Full=PSP24-1;
DE AltName: Full=PSP24-alpha;
GN Name=GPR45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-312.
RX PubMed=10036181; DOI=10.1006/geno.1998.5655;
RA Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H.Q., Nowak T.,
RA Im D.-S., Lynch K.R., George S.R., O'Dowd B.F.;
RT "Discovery of three novel orphan G-protein-coupled receptors.";
RL Genomics 56:12-21(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-7.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Orphan receptor. May play a role in brain function.
CC -!- INTERACTION:
CC Q9Y5Y3; P32243-2: OTX2; NbExp=3; IntAct=EBI-1751869, EBI-9087860;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in brain; detected in the basal
CC forebrain, frontal cortex, and caudate, but not in thalamus,
CC hippocampus, or putamen.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF118266; AAD21056.1; -; Genomic_DNA.
DR EMBL; AC012360; AAY15009.1; -; Genomic_DNA.
DR EMBL; BC066879; AAH66879.1; -; mRNA.
DR EMBL; BC066880; AAH66880.1; -; mRNA.
DR EMBL; BC067455; AAH67455.1; -; mRNA.
DR CCDS; CCDS2066.1; -.
DR RefSeq; NP_009158.3; NM_007227.3.
DR AlphaFoldDB; Q9Y5Y3; -.
DR SMR; Q9Y5Y3; -.
DR BioGRID; 116411; 358.
DR IntAct; Q9Y5Y3; 5.
DR STRING; 9606.ENSP00000258456; -.
DR ChEMBL; CHEMBL4523928; -.
DR GlyGen; Q9Y5Y3; 3 sites.
DR iPTMnet; Q9Y5Y3; -.
DR PhosphoSitePlus; Q9Y5Y3; -.
DR BioMuta; GPR45; -.
DR DMDM; 82654940; -.
DR PaxDb; Q9Y5Y3; -.
DR PeptideAtlas; Q9Y5Y3; -.
DR PRIDE; Q9Y5Y3; -.
DR Antibodypedia; 17832; 182 antibodies from 28 providers.
DR DNASU; 11250; -.
DR Ensembl; ENST00000258456.3; ENSP00000258456.1; ENSG00000135973.3.
DR GeneID; 11250; -.
DR KEGG; hsa:11250; -.
DR MANE-Select; ENST00000258456.3; ENSP00000258456.1; NM_007227.3; NP_009158.3.
DR UCSC; uc002tco.2; human.
DR CTD; 11250; -.
DR DisGeNET; 11250; -.
DR GeneCards; GPR45; -.
DR HGNC; HGNC:4503; GPR45.
DR HPA; ENSG00000135973; Tissue enhanced (brain).
DR MIM; 604838; gene.
DR neXtProt; NX_Q9Y5Y3; -.
DR OpenTargets; ENSG00000135973; -.
DR PharmGKB; PA28892; -.
DR VEuPathDB; HostDB:ENSG00000135973; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_9_1; -.
DR InParanoid; Q9Y5Y3; -.
DR OMA; YFCRLSA; -.
DR OrthoDB; 742446at2759; -.
DR PhylomeDB; Q9Y5Y3; -.
DR TreeFam; TF338633; -.
DR PathwayCommons; Q9Y5Y3; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; Q9Y5Y3; -.
DR BioGRID-ORCS; 11250; 16 hits in 1063 CRISPR screens.
DR GeneWiki; GPR45; -.
DR GenomeRNAi; 11250; -.
DR Pharos; Q9Y5Y3; Tbio.
DR PRO; PR:Q9Y5Y3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9Y5Y3; protein.
DR Bgee; ENSG00000135973; Expressed in cortical plate and 36 other tissues.
DR ExpressionAtlas; Q9Y5Y3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..372
FT /note="Probable G-protein coupled receptor 45"
FT /id="PRO_0000069574"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 7
FT /note="S -> C (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035759"
FT VARIANT 312
FT /note="L -> F (in dbSNP:rs35946826)"
FT /evidence="ECO:0000269|PubMed:10036181"
FT /id="VAR_049394"
FT CONFLICT 270
FT /note="L -> P (in Ref. 3; AAH67455)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 41967 MW; BA54EC7AE7E80193 CRC64;
MACNSTSLEA YTYLLLNTSN ASDSGSTQLP APLRISLAIV MLLMTVVGFL GNTVVCIIVY
QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAVTLITVRW HFGDHFCRLS ATLYWFFVLE
GVAILLIISV DRFLIIVQRQ DKLNPRRAKV IIAVSWVLSF CIAGPSLTGW TLVEVPARAP
QCVLGYTELP ADRAYVVTLV VAVFFAPFGV MLCAYMCILN TVRKNAVRVH NQSDSLDLRQ
LTRAGLRRLQ RQQQVSVDLS FKTKAFTTIL ILFVGFSLCW LPHSVYSLLS VFSQRFYCGS
SFYATSTCVL WLSYLKSVFN PIVYCWRIKK FREACIELLP QTFQILPKVP ERIRRRIQPS
TVYVCNENQS AV
