GPR45_MOUSE
ID GPR45_MOUSE Reviewed; 373 AA.
AC Q9EQQ4;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Probable G-protein coupled receptor 45;
DE AltName: Full=PSP24-1;
DE AltName: Full=PSP24-alpha;
GN Name=Gpr45;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11027574; DOI=10.1006/bbrc.2000.3569;
RA Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.;
RT "Brain-specific expression of novel G-protein-coupled receptors, with
RT homologies to Xenopus PSP24 and human GPR45.";
RL Biochem. Biophys. Res. Commun. 276:952-956(2000).
CC -!- FUNCTION: Orphan receptor. May play a role in brain function.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain specific.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF139642; AAG42572.1; -; Genomic_DNA.
DR CCDS; CCDS14919.1; -.
DR RefSeq; NP_444337.3; NM_053107.4.
DR RefSeq; XP_006496409.1; XM_006496346.2.
DR RefSeq; XP_006496410.1; XM_006496347.2.
DR RefSeq; XP_006496411.1; XM_006496348.2.
DR RefSeq; XP_017168482.1; XM_017312993.1.
DR AlphaFoldDB; Q9EQQ4; -.
DR SMR; Q9EQQ4; -.
DR STRING; 10090.ENSMUSP00000135986; -.
DR GlyGen; Q9EQQ4; 1 site.
DR iPTMnet; Q9EQQ4; -.
DR PhosphoSitePlus; Q9EQQ4; -.
DR PaxDb; Q9EQQ4; -.
DR PRIDE; Q9EQQ4; -.
DR ProteomicsDB; 271069; -.
DR Antibodypedia; 17832; 182 antibodies from 28 providers.
DR DNASU; 93690; -.
DR Ensembl; ENSMUST00000114761; ENSMUSP00000110409; ENSMUSG00000041907.
DR Ensembl; ENSMUST00000179766; ENSMUSP00000135986; ENSMUSG00000041907.
DR GeneID; 93690; -.
DR KEGG; mmu:93690; -.
DR UCSC; uc007avd.2; mouse.
DR CTD; 11250; -.
DR MGI; MGI:2135882; Gpr45.
DR VEuPathDB; HostDB:ENSMUSG00000041907; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_9_1; -.
DR InParanoid; Q9EQQ4; -.
DR OMA; YFCRLSA; -.
DR OrthoDB; 742446at2759; -.
DR PhylomeDB; Q9EQQ4; -.
DR TreeFam; TF338633; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 93690; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9EQQ4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9EQQ4; protein.
DR Bgee; ENSMUSG00000041907; Expressed in cortical plate and 62 other tissues.
DR ExpressionAtlas; Q9EQQ4; baseline and differential.
DR Genevisible; Q9EQQ4; MM.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..373
FT /note="Probable G-protein coupled receptor 45"
FT /id="PRO_0000069575"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 373 AA; 42358 MW; 693BE5DE9673FB2D CRC64;
MACNSTPMGT YEHLLLNVSN TLDPGDTPLS APLRISLAIM MLLMIVVGFL GNTVVCIIVY
QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAITLITVRW HFGDHFCRLS ATLYWFFVLE
GVAILLIISV DRFLIIVQRQ DKLNPRRAKM IIAASWVLSF CISAPSFTGW TFMEVPARAP
QCVLGYTEFP AERAYVVTLV VAVFFAPFGV MLCSYLCILN TVRKNAVRVH NQSDSLDLRQ
LTGAGLRRLR RQQQQASLDL SFKTKAFTTI LILFVGFSLC WLPHSVYSLL SAFSRRFYYS
ASFYTTSTCV LWLSYLKSVF NPIVYCWRIK KFREACIELL PHTFQILPKV PERIQRKIQP
STIYVCNENQ SAV
