GPR63_HUMAN
ID GPR63_HUMAN Reviewed; 419 AA.
AC Q9BZJ6; Q9UJH3;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Probable G-protein coupled receptor 63;
DE AltName: Full=PSP24-2;
DE AltName: Full=PSP24-beta;
GN Name=GPR63; Synonyms=PSP24B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11165367; DOI=10.1016/s0169-328x(00)00242-4;
RA Lee D.K., George S.R., Cheng R., Nguyen T., Liu Y., Brown M., Lynch K.R.,
RA O'Dowd B.F.;
RT "Identification of four novel human G protein-coupled receptors expressed
RT in the brain.";
RL Brain Res. Mol. Brain Res. 86:13-22(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11027574; DOI=10.1006/bbrc.2000.3569;
RA Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.;
RT "Brain-specific expression of novel G-protein-coupled receptors, with
RT homologies to Xenopus PSP24 and human GPR45.";
RL Biochem. Biophys. Res. Commun. 276:952-956(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor. May play a role in brain function.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in brain; detected in the frontal cortex,
CC with lower levels in the thalamus, caudate, hypothalamus and midbrain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF317654; AAK12639.2; -; Genomic_DNA.
DR EMBL; AB030566; BAB20031.1; -; mRNA.
DR EMBL; AL033379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067465; AAH67465.1; -; mRNA.
DR EMBL; BC067469; AAH67469.1; -; mRNA.
DR CCDS; CCDS5036.1; -.
DR RefSeq; NP_001137429.1; NM_001143957.2.
DR RefSeq; NP_110411.1; NM_030784.3.
DR RefSeq; XP_006715633.1; XM_006715570.3.
DR RefSeq; XP_011534455.1; XM_011536153.2.
DR RefSeq; XP_011534456.1; XM_011536154.2.
DR RefSeq; XP_011534457.1; XM_011536155.2.
DR RefSeq; XP_011534459.1; XM_011536157.2.
DR RefSeq; XP_011534461.1; XM_011536159.2.
DR RefSeq; XP_016866823.1; XM_017011334.1.
DR AlphaFoldDB; Q9BZJ6; -.
DR SMR; Q9BZJ6; -.
DR IntAct; Q9BZJ6; 2.
DR MINT; Q9BZJ6; -.
DR STRING; 9606.ENSP00000229955; -.
DR ChEMBL; CHEMBL4523916; -.
DR GuidetoPHARMACOLOGY; 112; -.
DR GlyGen; Q9BZJ6; 3 sites.
DR iPTMnet; Q9BZJ6; -.
DR PhosphoSitePlus; Q9BZJ6; -.
DR BioMuta; GPR63; -.
DR DMDM; 21263685; -.
DR PaxDb; Q9BZJ6; -.
DR PeptideAtlas; Q9BZJ6; -.
DR PRIDE; Q9BZJ6; -.
DR ProteomicsDB; 79860; -.
DR Antibodypedia; 18869; 231 antibodies from 28 providers.
DR DNASU; 81491; -.
DR Ensembl; ENST00000229955.4; ENSP00000229955.2; ENSG00000112218.9.
DR GeneID; 81491; -.
DR KEGG; hsa:81491; -.
DR MANE-Select; ENST00000229955.4; ENSP00000229955.2; NM_030784.4; NP_110411.1.
DR UCSC; uc003pou.4; human.
DR CTD; 81491; -.
DR DisGeNET; 81491; -.
DR GeneCards; GPR63; -.
DR HGNC; HGNC:13302; GPR63.
DR HPA; ENSG00000112218; Low tissue specificity.
DR MIM; 606915; gene.
DR neXtProt; NX_Q9BZJ6; -.
DR OpenTargets; ENSG00000112218; -.
DR PharmGKB; PA28907; -.
DR VEuPathDB; HostDB:ENSG00000112218; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_9_1; -.
DR InParanoid; Q9BZJ6; -.
DR OMA; AMLFWFF; -.
DR OrthoDB; 742446at2759; -.
DR PhylomeDB; Q9BZJ6; -.
DR TreeFam; TF332301; -.
DR PathwayCommons; Q9BZJ6; -.
DR SignaLink; Q9BZJ6; -.
DR BioGRID-ORCS; 81491; 4 hits in 1067 CRISPR screens.
DR GeneWiki; GPR63; -.
DR GenomeRNAi; 81491; -.
DR Pharos; Q9BZJ6; Tchem.
DR PRO; PR:Q9BZJ6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9BZJ6; protein.
DR Bgee; ENSG00000112218; Expressed in cortical plate and 95 other tissues.
DR ExpressionAtlas; Q9BZJ6; baseline and differential.
DR Genevisible; Q9BZJ6; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0043235; C:receptor complex; IDA:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..419
FT /note="Probable G-protein coupled receptor 63"
FT /id="PRO_0000069581"
FT TOPO_DOM 1..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..104
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..138
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..157
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..177
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..263
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..338
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..352
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..375
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 21
FT /note="V -> M (in dbSNP:rs35358396)"
FT /id="VAR_049396"
SQ SEQUENCE 419 AA; 47578 MW; 17418CD0AE1D6C8D CRC64;
MVFSAVLTAF HTGTSNTTFV VYENTYMNIT LPPPFQHPDL SPLLRYSFET MAPTGLSSLT
VNSTAVPTTP AAFKSLNLPL QITLSAIMIF ILFVSFLGNL VVCLMVYQKA AMRSAINILL
ASLAFADMLL AVLNMPFALV TILTTRWIFG KFFCRVSAMF FWLFVIEGVA ILLIISIDRF
LIIVQRQDKL NPYRAKVLIA VSWATSFCVA FPLAVGNPDL QIPSRAPQCV FGYTTNPGYQ
AYVILISLIS FFIPFLVILY SFMGILNTLR HNALRIHSYP EGICLSQASK LGLMSLQRPF
QMSIDMGFKT RAFTTILILF AVFIVCWAPF TTYSLVATFS KHFYYQHNFF EISTWLLWLC
YLKSALNPLI YYWRIKKFHD ACLDMMPKSF KFLPQLPGHT KRRIRPSAVY VCGEHRTVV
