GPR63_MOUSE
ID GPR63_MOUSE Reviewed; 425 AA.
AC Q9EQQ3; Q8BZ93;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Probable G-protein coupled receptor 63;
DE AltName: Full=PSP24-2;
DE AltName: Full=PSP24-beta;
GN Name=Gpr63;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11027574; DOI=10.1006/bbrc.2000.3569;
RA Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.;
RT "Brain-specific expression of novel G-protein-coupled receptors, with
RT homologies to Xenopus PSP24 and human GPR45.";
RL Biochem. Biophys. Res. Commun. 276:952-956(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Orphan receptor. May play a role in brain function.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Brain specific.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF139643; AAG42573.1; -; Genomic_DNA.
DR EMBL; AK036257; BAC29364.1; -; mRNA.
DR EMBL; AL772199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466538; EDL05529.1; -; Genomic_DNA.
DR CCDS; CCDS18008.1; -.
DR RefSeq; NP_109658.2; NM_030733.3.
DR RefSeq; XP_006538445.1; XM_006538382.3.
DR RefSeq; XP_006538446.1; XM_006538383.3.
DR AlphaFoldDB; Q9EQQ3; -.
DR SMR; Q9EQQ3; -.
DR STRING; 10090.ENSMUSP00000039312; -.
DR GlyGen; Q9EQQ3; 3 sites.
DR PhosphoSitePlus; Q9EQQ3; -.
DR PaxDb; Q9EQQ3; -.
DR PRIDE; Q9EQQ3; -.
DR ProteomicsDB; 271276; -.
DR Antibodypedia; 18869; 231 antibodies from 28 providers.
DR DNASU; 81006; -.
DR Ensembl; ENSMUST00000038920; ENSMUSP00000039312; ENSMUSG00000040372.
DR GeneID; 81006; -.
DR KEGG; mmu:81006; -.
DR UCSC; uc008see.1; mouse.
DR CTD; 81491; -.
DR MGI; MGI:2135884; Gpr63.
DR VEuPathDB; HostDB:ENSMUSG00000040372; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_9_1; -.
DR InParanoid; Q9EQQ3; -.
DR OMA; AMLFWFF; -.
DR OrthoDB; 742446at2759; -.
DR PhylomeDB; Q9EQQ3; -.
DR TreeFam; TF332301; -.
DR BioGRID-ORCS; 81006; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q9EQQ3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9EQQ3; protein.
DR Bgee; ENSMUSG00000040372; Expressed in secondary oocyte and 52 other tissues.
DR Genevisible; Q9EQQ3; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..425
FT /note="Probable G-protein coupled receptor 63"
FT /id="PRO_0000069582"
FT TOPO_DOM 1..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..112
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..148
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..190
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..222
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..272
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..345
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..379
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 407
FT /note="R -> S (in Ref. 1; AAG42573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 47788 MW; E9E99B8E51DDED36 CRC64;
MVVSGVLTAP AVLTAPHSGT SNTTFVVFEN SHVNITAPLP FQHPSAGPLL RYSLETMTSP
GFSSLAVNST AVTPAPAVFK SLNLAVQIIL SAIMIFILFV SFLGNLVVCL MVYQKAAMRS
AINILLASLA FADMLLAVLN MPFALVTILT TRWIFGKFFC RLSAMFFWLF VIEGVAILLI
ISIDRFLIIV QRQDKLNPYR AKVLIAVSWA TAFSVAFPLA VGNPDLQIPS RAPQCVFGYT
TNSGYQAYVI LISLISFFIP FLVILYSFMG ILNTLRHNAL RIHSYPEGIC LSQASKLGLM
SLQRPFQMSI DMGFKTRAFT TILILFAVFI VCWAPFTTYS LVATFSKHFY YQHNFFEIST
WLLWLCYLKS ALNPLIYYWR IKKFHDACLD MMPKSFKFLP RLPGHTRRRI RPSAVYVCGE
HRTVL
