GPR75_MOUSE
ID GPR75_MOUSE Reviewed; 540 AA.
AC Q6X632; Q3URC1; Q8BXP3;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable G-protein coupled receptor 75;
GN Name=Gpr75;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Brain;
RX PubMed=17001303; DOI=10.1038/sj.bjp.0706909;
RA Ignatov A., Robert J., Gregory-Evans C., Schaller H.C.;
RT "RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3)
RT formation in cells transfected with G protein-coupled receptor 75.";
RL Br. J. Pharmacol. 149:490-497(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=23979485; DOI=10.1007/s00125-013-3022-x;
RA Liu B., Hassan Z., Amisten S., King A.J., Bowe J.E., Huang G.C.,
RA Jones P.M., Persaud S.J.;
RT "The novel chemokine receptor, G-protein-coupled receptor 75, is expressed
RT by islets and is coupled to stimulation of insulin secretion and improved
RT glucose homeostasis.";
RL Diabetologia 56:2467-2476(2013).
CC -!- FUNCTION: G protein-coupled receptor that is activated by the chemokine
CC CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it
CC stimulates inositol trisphosphate production and calcium mobilization
CC upon activation. Together with CCL5/RANTES, may play a role in neuron
CC survival through activation of a downstream signaling pathway involving
CC the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin
CC secretion by pancreatic islet cells through activation of this
CC receptor. {ECO:0000269|PubMed:17001303, ECO:0000303|PubMed:23979485}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000305|PubMed:17001303}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and heart. Also detected
CC in skeletal muscle, liver and kidney. Also expressed by islet cells (at
CC protein level). {ECO:0000269|PubMed:17001303,
CC ECO:0000269|PubMed:23979485}.
CC -!- DEVELOPMENTAL STAGE: Expressed at 7 dpc and 11 dpc. Also detected at 17
CC dpc. {ECO:0000269|PubMed:17001303}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31978.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY253852; AAP83130.1; -; mRNA.
DR EMBL; AK044553; BAC31978.1; ALT_INIT; mRNA.
DR EMBL; AK141614; BAE24767.1; -; mRNA.
DR EMBL; AL662891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24508.1; -.
DR RefSeq; NP_780699.2; NM_175490.4.
DR RefSeq; XP_006514759.1; XM_006514696.3.
DR AlphaFoldDB; Q6X632; -.
DR SMR; Q6X632; -.
DR STRING; 10090.ENSMUSP00000105057; -.
DR GlyGen; Q6X632; 3 sites.
DR iPTMnet; Q6X632; -.
DR PhosphoSitePlus; Q6X632; -.
DR PaxDb; Q6X632; -.
DR PRIDE; Q6X632; -.
DR Antibodypedia; 15401; 412 antibodies from 32 providers.
DR DNASU; 237716; -.
DR Ensembl; ENSMUST00000109430; ENSMUSP00000105057; ENSMUSG00000043999.
DR GeneID; 237716; -.
DR KEGG; mmu:237716; -.
DR UCSC; uc007iib.2; mouse.
DR CTD; 10936; -.
DR MGI; MGI:2441843; Gpr75.
DR VEuPathDB; HostDB:ENSMUSG00000043999; -.
DR eggNOG; ENOG502QVED; Eukaryota.
DR GeneTree; ENSGT00390000007723; -.
DR HOGENOM; CLU_041999_0_0_1; -.
DR InParanoid; Q6X632; -.
DR OMA; GHQHYGQ; -.
DR OrthoDB; 1363902at2759; -.
DR PhylomeDB; Q6X632; -.
DR TreeFam; TF331523; -.
DR BioGRID-ORCS; 237716; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q6X632; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6X632; protein.
DR Bgee; ENSMUSG00000043999; Expressed in lumbar dorsal root ganglion and 77 other tissues.
DR ExpressionAtlas; Q6X632; baseline and differential.
DR Genevisible; Q6X632; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IDA:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:1901214; P:regulation of neuron death; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..540
FT /note="Probable G-protein coupled receptor 75"
FT /id="PRO_0000069584"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..350
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 443..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 476
FT /note="N -> D (in Ref. 2; BAC31978)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 540 AA; 59531 MW; E8704067FCC70E69 CRC64;
MNTSAPLQNV PNATLLNMPP LHGGNSTSLQ EGLRDFIHTA TLVTCTFLLA IIFCLGSYGN
FIVFLSFFDP SFRKFRTNFD FMILNLSFCD LFICGVTAPM FTFVLFFSSA SSIPDSFCFT
FHLTSSGFVI MSLKMVAVIA LHRLRMVMGK QPNCTASFSC ILLLTLLLWA TSFTLATLAT
LRTNKSHLCL PMSSLMDGEG KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVKKCPP
VITVDASRPQ PFMGASVKGN GDPIQCTMPA LYRNQNYNKL QHSQTHGYTK NINQMPIPSA
SRLQLVSAIN FSTAKDSKAV VTCVVIVLSV LVCCLPLGIS LVQMVLSDNG SFILYQFELF
GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LRYTGLGFLC CKQKTRLRAM GKGNLEINRN
KSSHHETNSA YMLSPKPQRK FVDQACGPSH SKESAASPKV SAGHQPCGQS SSTPINTRIE
PYYSIYNSSP SQQESGPANL PPVNSFGFAS SYIAMHYYTT NDLMQEYDST SAKQIPIPSV
