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GPR78_HUMAN
ID   GPR78_HUMAN             Reviewed;         363 AA.
AC   Q96P69; Q8NGV3;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=G-protein coupled receptor 78;
GN   Name=GPR78; ORFNames=UNQ5925/PRO19818;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA   Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA   Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT   "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL   Gene 275:83-91(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF ARG-236.
RX   PubMed=17363172; DOI=10.1016/j.bbagen.2007.01.013;
RA   Jones P.G., Nawoschik S.P., Sreekumar K., Uveges A.J., Tseng E., Zhang L.,
RA   Johnson J., He L., Paulsen J.E., Bates B., Pausch M.H.;
RT   "Tissue distribution and functional analyses of the constitutively active
RT   orphan G protein coupled receptors, GPR26 and GPR78.";
RL   Biochim. Biophys. Acta 1770:890-901(2007).
CC   -!- FUNCTION: Orphan receptor. Displays a significant level of constitutive
CC       activity. Its effect is mediated by G(s)-alpha protein that stimulate
CC       adenylate cyclase, resulting in an elevation of intracellular cAMP.
CC       {ECO:0000269|PubMed:17363172}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: High level of expression in placenta. Expressed
CC       throughout the brain at low level. No expression detected in skeletal
CC       muscle, lung, heart, liver, pancreas, or kidney.
CC       {ECO:0000269|PubMed:17363172}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF411107; AAL26479.1; -; mRNA.
DR   EMBL; AB065673; BAC05898.1; -; Genomic_DNA.
DR   EMBL; AY359107; AAQ89465.1; -; mRNA.
DR   EMBL; BC057778; AAH57778.1; -; mRNA.
DR   EMBL; BC069343; AAH69343.1; -; mRNA.
DR   EMBL; BC069813; AAH69813.1; -; mRNA.
DR   CCDS; CCDS3403.1; -.
DR   RefSeq; NP_543009.2; NM_080819.4.
DR   AlphaFoldDB; Q96P69; -.
DR   SMR; Q96P69; -.
DR   BioGRID; 118076; 1.
DR   STRING; 9606.ENSP00000371927; -.
DR   ChEMBL; CHEMBL4523908; -.
DR   iPTMnet; Q96P69; -.
DR   PhosphoSitePlus; Q96P69; -.
DR   BioMuta; GPR78; -.
DR   MassIVE; Q96P69; -.
DR   PaxDb; Q96P69; -.
DR   PeptideAtlas; Q96P69; -.
DR   PRIDE; Q96P69; -.
DR   Antibodypedia; 9632; 209 antibodies from 29 providers.
DR   DNASU; 27201; -.
DR   Ensembl; ENST00000382487.5; ENSP00000371927.4; ENSG00000155269.12.
DR   GeneID; 27201; -.
DR   KEGG; hsa:27201; -.
DR   MANE-Select; ENST00000382487.5; ENSP00000371927.4; NM_080819.5; NP_543009.2.
DR   UCSC; uc003glk.5; human.
DR   CTD; 27201; -.
DR   DisGeNET; 27201; -.
DR   GeneCards; GPR78; -.
DR   HGNC; HGNC:4528; GPR78.
DR   HPA; ENSG00000155269; Tissue enhanced (esophagus, placenta).
DR   MIM; 606921; gene.
DR   neXtProt; NX_Q96P69; -.
DR   OpenTargets; ENSG00000155269; -.
DR   PharmGKB; PA28921; -.
DR   VEuPathDB; HostDB:ENSG00000155269; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00950000183001; -.
DR   InParanoid; Q96P69; -.
DR   OMA; MDIVTMK; -.
DR   OrthoDB; 1039292at2759; -.
DR   PhylomeDB; Q96P69; -.
DR   TreeFam; TF332434; -.
DR   PathwayCommons; Q96P69; -.
DR   BioGRID-ORCS; 27201; 8 hits in 1063 CRISPR screens.
DR   ChiTaRS; GPR78; human.
DR   GeneWiki; GPR78; -.
DR   GenomeRNAi; 27201; -.
DR   Pharos; Q96P69; Tbio.
DR   PRO; PR:Q96P69; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q96P69; protein.
DR   Bgee; ENSG00000155269; Expressed in lower esophagus mucosa and 59 other tissues.
DR   ExpressionAtlas; Q96P69; baseline and differential.
DR   Genevisible; Q96P69; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..363
FT                   /note="G-protein coupled receptor 78"
FT                   /id="PRO_0000069585"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..47
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..168
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        264..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..363
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          340..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        79..156
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         201
FT                   /note="R -> S (in dbSNP:rs17844778)"
FT                   /id="VAR_024258"
FT   VARIANT         330
FT                   /note="A -> T (in dbSNP:rs11941659)"
FT                   /id="VAR_033474"
FT   VARIANT         342
FT                   /note="R -> H (in dbSNP:rs9685931)"
FT                   /id="VAR_033475"
FT   MUTAGEN         236
FT                   /note="R->E: No effect on constitutive activity."
FT                   /evidence="ECO:0000269|PubMed:17363172"
FT   CONFLICT        216
FT                   /note="L -> V (in Ref. 1; AAL26479)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        226..227
FT                   /note="QR -> HG (in Ref. 1; AAL26479)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   363 AA;  39332 MW;  2C0052A0A1A22A93 CRC64;
     MGPGEALLAG LLVMVLAVAL LSNALVLLCC AYSAELRTRA SGVLLVNLSL GHLLLAALDM
     PFTLLGVMRG RTPSAPGACQ VIGFLDTFLA SNAALSVAAL SADQWLAVGF PLRYAGRLRP
     RYAGLLLGCA WGQSLAFSGA ALGCSWLGYS SAFASCSLRL PPEPERPRFA AFTATLHAVG
     FVLPLAVLCL TSLQVHRVAR RHCQRMDTVT MKALALLADL HPSVRQRCLI QQKRRRHRAT
     RKIGIAIATF LICFAPYVMT RLAELVPFVT VNAQWGILSK CLTYSKAVAD PFTYSLLRRP
     FRQVLAGMVH RLLKRTPRPA STHDSSLDVA GMVHQLLKRT PRPASTHNGS VDTENDSCLQ
     QTH
 
 
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