GPR85_MOUSE
ID GPR85_MOUSE Reviewed; 370 AA.
AC P60894; Q9JHI6; Q9NPD1;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable G-protein coupled receptor 85;
DE AltName: Full=Super conserved receptor expressed in brain 2;
GN Name=Gpr85; Synonyms=Sreb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=CD-1; TISSUE=Fetal brain;
RX PubMed=10978537; DOI=10.1016/s0167-4781(00)00182-2;
RA Hellebrand S., Schaller H.C., Wittenberger T.;
RT "The brain-specific G-protein coupled receptor GPR85 with identical protein
RT sequence in man and mouse maps to human chromosome 7q31.";
RL Biochim. Biophys. Acta 1493:269-272(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBUNIT: Interacts with DLG4 AND DLG3. {ECO:0000250|UniProtKB:P60893}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P60893}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in brain.
CC {ECO:0000269|PubMed:10978537}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF254416; AAF79959.1; -; mRNA.
DR EMBL; BC026975; AAH26975.1; -; mRNA.
DR EMBL; BC065154; AAH65154.1; -; mRNA.
DR CCDS; CCDS19916.1; -.
DR RefSeq; NP_001317595.1; NM_001330666.1.
DR RefSeq; NP_001317596.1; NM_001330667.1.
DR RefSeq; NP_659503.1; NM_145066.5.
DR RefSeq; XP_006505221.1; XM_006505158.3.
DR RefSeq; XP_011239381.1; XM_011241079.2.
DR RefSeq; XP_017177194.1; XM_017321705.1.
DR AlphaFoldDB; P60894; -.
DR SMR; P60894; -.
DR BioGRID; 211078; 1.
DR STRING; 10090.ENSMUSP00000053837; -.
DR GlyGen; P60894; 3 sites.
DR PhosphoSitePlus; P60894; -.
DR PaxDb; P60894; -.
DR PRIDE; P60894; -.
DR Antibodypedia; 17381; 171 antibodies from 26 providers.
DR DNASU; 64450; -.
DR Ensembl; ENSMUST00000060442; ENSMUSP00000053837; ENSMUSG00000048216.
DR Ensembl; ENSMUST00000115491; ENSMUSP00000111154; ENSMUSG00000048216.
DR Ensembl; ENSMUST00000115492; ENSMUSP00000111155; ENSMUSG00000048216.
DR GeneID; 64450; -.
DR KEGG; mmu:64450; -.
DR UCSC; uc009ayr.1; mouse.
DR CTD; 54329; -.
DR MGI; MGI:1927851; Gpr85.
DR VEuPathDB; HostDB:ENSMUSG00000048216; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00890000139436; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR InParanoid; P60894; -.
DR OMA; ARGPIVP; -.
DR OrthoDB; 1311948at2759; -.
DR PhylomeDB; P60894; -.
DR TreeFam; TF331163; -.
DR BioGRID-ORCS; 64450; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Gpr85; mouse.
DR PRO; PR:P60894; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P60894; protein.
DR Bgee; ENSMUSG00000048216; Expressed in barrel cortex and 210 other tissues.
DR ExpressionAtlas; P60894; baseline and differential.
DR Genevisible; P60894; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Endoplasmic reticulum;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..370
FT /note="Probable G-protein coupled receptor 85"
FT /id="PRO_0000069592"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 370 AA; 41995 MW; 7B67A39F6166AAEB CRC64;
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL
DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY
LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR
ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA
ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS
RLPREPYCVI
