GPR87_HUMAN
ID GPR87_HUMAN Reviewed; 358 AA.
AC Q9BY21; Q5KU35; Q96JZ8; Q9BXC2;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=G-protein coupled receptor 87;
DE AltName: Full=G-protein coupled receptor 95;
GN Name=GPR87; Synonyms=GPR95; ORFNames=FKSG78;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Urakawa I., Hirose M., Yamano S., Okazaki H.;
RT "Probable G-protein coupled receptor.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL Gene 275:83-91(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11273702; DOI=10.1006/jmbi.2001.4520;
RA Wittenberger T., Schaller H.C., Hellebrand S.;
RT "An expressed sequence tag (EST) data mining strategy succeeding in the
RT discovery of new G-protein coupled receptors.";
RL J. Mol. Biol. 307:799-813(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Kaighin V.A., Martin A.L., Aronstam R.S.;
RT "Isolation of cDNA coding for human orphan G protein receptor 87.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, Testis, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-358.
RC TISSUE=Heart;
RA Wang Y.-G., Gong L.;
RT "Identification of FKSG78, a novel gene encoding a putative G-protein-
RT coupled receptor.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17905198; DOI=10.1016/j.bbrc.2007.09.063;
RA Tabata K., Baba K., Shiraishi A., Ito M., Fujita N.;
RT "The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic
RT acid receptor.";
RL Biochem. Biophys. Res. Commun. 363:861-866(2007).
RN [10]
RP FUNCTION, AND INDUCTION.
RX PubMed=19602589; DOI=10.1158/0008-5472.can-09-0621;
RA Zhang Y., Qian Y., Lu W., Chen X.;
RT "The G protein-coupled receptor 87 is necessary for p53-dependent cell
RT survival in response to genotoxic stress.";
RL Cancer Res. 69:6049-6056(2009).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] TYR-191.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Receptor for lysophosphatidic acid (LPA). Necessary for
CC p53/TP53-dependent survival in response to DNA damage.
CC {ECO:0000269|PubMed:17905198, ECO:0000269|PubMed:19602589}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta and prostate. Weaker
CC expression in thymus. Not expressed in thalamus, hippocampus, pons or
CC cerebellum. Overexpressed in squamous cell carcinoma of the lung.
CC {ECO:0000269|PubMed:17905198}.
CC -!- INDUCTION: By expression of p53/TP53 and by DNA damage in a TP53-
CC dependent manner. {ECO:0000269|PubMed:19602589}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK29069.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB031548; BAD83583.1; -; mRNA.
DR EMBL; AF411114; AAL26485.1; -; mRNA.
DR EMBL; AF237763; AAK01858.1; -; mRNA.
DR EMBL; EU883576; ACG60650.1; -; mRNA.
DR EMBL; AK027784; BAB55366.1; -; mRNA.
DR EMBL; CH471052; EAW78808.1; -; Genomic_DNA.
DR EMBL; BC009540; AAH09540.2; -; mRNA.
DR EMBL; BC112941; AAI12942.1; -; mRNA.
DR EMBL; BC117565; AAI17566.1; -; mRNA.
DR EMBL; BC132888; AAI32889.1; -; mRNA.
DR EMBL; BC132890; AAI32891.1; -; mRNA.
DR EMBL; AF345566; AAK29069.1; ALT_INIT; mRNA.
DR CCDS; CCDS3157.1; -.
DR RefSeq; NP_076404.3; NM_023915.3.
DR AlphaFoldDB; Q9BY21; -.
DR SMR; Q9BY21; -.
DR BioGRID; 119807; 1.
DR IntAct; Q9BY21; 6.
DR MINT; Q9BY21; -.
DR STRING; 9606.ENSP00000260843; -.
DR ChEMBL; CHEMBL4523915; -.
DR GuidetoPHARMACOLOGY; 122; -.
DR TCDB; 3.A.16.1.4; the endoplasmic reticular retrotranslocon (er-rt) family.
DR GlyGen; Q9BY21; 4 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BY21; -.
DR PhosphoSitePlus; Q9BY21; -.
DR BioMuta; GPR87; -.
DR DMDM; 37537842; -.
DR MassIVE; Q9BY21; -.
DR PaxDb; Q9BY21; -.
DR PeptideAtlas; Q9BY21; -.
DR PRIDE; Q9BY21; -.
DR ProteomicsDB; 79569; -.
DR Antibodypedia; 18298; 238 antibodies from 28 providers.
DR DNASU; 53836; -.
DR Ensembl; ENST00000260843.5; ENSP00000260843.4; ENSG00000138271.6.
DR GeneID; 53836; -.
DR KEGG; hsa:53836; -.
DR MANE-Select; ENST00000260843.5; ENSP00000260843.4; NM_023915.4; NP_076404.3.
DR UCSC; uc003eyt.4; human.
DR CTD; 53836; -.
DR DisGeNET; 53836; -.
DR GeneCards; GPR87; -.
DR HGNC; HGNC:4538; GPR87.
DR HPA; ENSG00000138271; Tissue enhanced (esophagus, skin, vagina).
DR MIM; 606379; gene.
DR neXtProt; NX_Q9BY21; -.
DR OpenTargets; ENSG00000138271; -.
DR PharmGKB; PA28931; -.
DR VEuPathDB; HostDB:ENSG00000138271; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244982; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q9BY21; -.
DR OMA; YINTCTF; -.
DR OrthoDB; 784055at2759; -.
DR PhylomeDB; Q9BY21; -.
DR TreeFam; TF330969; -.
DR PathwayCommons; Q9BY21; -.
DR SignaLink; Q9BY21; -.
DR BioGRID-ORCS; 53836; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; GPR87; human.
DR GeneWiki; GPR87; -.
DR GenomeRNAi; 53836; -.
DR Pharos; Q9BY21; Tchem.
DR PRO; PR:Q9BY21; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BY21; protein.
DR Bgee; ENSG00000138271; Expressed in tongue squamous epithelium and 92 other tissues.
DR Genevisible; Q9BY21; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008109; P2Y13_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01735; P2Y13PRNCPTR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="G-protein coupled receptor 87"
FT /id="PRO_0000069595"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 191
FT /note="D -> Y (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035760"
FT VARIANT 205
FT /note="T -> M (in dbSNP:rs35521104)"
FT /id="VAR_055921"
FT CONFLICT 154
FT /note="S -> N (in Ref. 5; BAB55366)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 358 AA; 41436 MW; FDF157295BE5D10F CRC64;
MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL IIFVASILLN
GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH DAGFGPWYFK FILCRYTSVL
FYANMYTSIV FLGLISIDRY LKVVKPFGDS RMYSITFTKV LSVCVWVIMA VLSLPNIILT
NGQPTEDNIH DCSKLKSPLG VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF
ISQSSRKRKH NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL
FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR IYYDYTDV
