GPRS_DROME
ID GPRS_DROME Reviewed; 1302 AA.
AC O61366; Q9V7S2;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2003, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Serine-enriched protein;
GN Name=gprs; ORFNames=CG18471;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF57972.2};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 526-1302.
RC STRAIN=Canton-S;
RA Da Lage J.-L.;
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE013599; AAF57972.2; -; Genomic_DNA.
DR EMBL; AF022713; AAD09150.2; -; Genomic_DNA.
DR RefSeq; NP_725599.2; NM_166186.3.
DR AlphaFoldDB; O61366; -.
DR BioGRID; 62574; 1.
DR IntAct; O61366; 4.
DR STRING; 7227.FBpp0086255; -.
DR PaxDb; O61366; -.
DR PRIDE; O61366; -.
DR EnsemblMetazoa; FBtr0087109; FBpp0086255; FBgn0024232.
DR GeneID; 36862; -.
DR KEGG; dme:Dmel_CG18471; -.
DR UCSC; CG18471-RA; d. melanogaster.
DR CTD; 36862; -.
DR FlyBase; FBgn0024232; gprs.
DR VEuPathDB; VectorBase:FBgn0024232; -.
DR eggNOG; KOG4350; Eukaryota.
DR GeneTree; ENSGT00950000182983; -.
DR HOGENOM; CLU_267779_0_0_1; -.
DR InParanoid; O61366; -.
DR PhylomeDB; O61366; -.
DR BioGRID-ORCS; 36862; 0 hits in 1 CRISPR screen.
DR ChiTaRS; gprs; fly.
DR GenomeRNAi; 36862; -.
DR PRO; PR:O61366; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0024232; Expressed in brain and 4 other tissues.
DR ExpressionAtlas; O61366; baseline and differential.
DR Genevisible; O61366; DM.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 2.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..1302
FT /note="Serine-enriched protein"
FT /id="PRO_0000186220"
FT DOMAIN 40..158
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037,
FT ECO:0000305"
FT REGION 325..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..360
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 691
FT /note="E -> D (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
FT CONFLICT 744
FT /note="Q -> H (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
FT CONFLICT 788
FT /note="D -> V (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
FT CONFLICT 808
FT /note="Q -> L (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
FT CONFLICT 894
FT /note="D -> V (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
FT CONFLICT 1167
FT /note="R -> G (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
FT CONFLICT 1301
FT /note="S -> N (in Ref. 3; AAD09150)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1302 AA; 144769 MW; DA3603B725140215 CRC64;
MPEALILPGM ADAEPDLSTF ENKTGLAEDM KFLASMPELC DVTFLVGDTR EPVCAVKAVL
ASRSRVFAKM LYAAPSPQRK RETSTKENKL RLFLKRSSEP LLNLQNAAQQ RTGYTQQLAP
IPEPSGQQHQ TLIIEEFEPD VFRQLIEYIH TGCVTLQPRT LLGVMNAADY YGLEELRRAC
AGFVQCCINV DTVCALLASA ERYIQYKCTK TLVQKVLEFV DEHGTEVLNL GSFTLLPQHV
VRLILAREEL RADEFTKFQA ALMWSKKYYD NNPNIDIKEI LGTFCEYIQF HKIPANVLMR
EIHPLNLVPY AIIMNALAYQ ADPESIDPGK LSPNSSRQHH RHRHHHQSLP KIRKAKSQSF
RTRRSPSERR SPNNAPNLTL NTSLTSGNGE KKRSPLTPKS PVMPVPESKS PGSSSQKTPT
SLSRQGTLRA SNRRKNSGQL SISLGTQGRR SPVGLNDRSP QGRRSPLFPS SGLRSPNDPM
TSPTVRSPTG EPRRSSPTFS VHTQERRSPL GAVAPTDFGC QFGVPGTRRS PTSTVHVQDM
ATEPEEAGFV GLKRPSISLF TPIYFASEKR SPMGPIPPIT VSNPAETYKS AEREREAAEA
AAREKEKEKE KEAAQPQEKK SVMREILAFV RKPSKHLSSR TNRFANAFTR AESGSSGGPL
IRQSTFSASP AASSTAAKSA VQKQMSEVGF EPKISQKFTH YAKMSLRLRR STKRDDEEKE
KQKQSSASGS KRPSADLSQT NADQQVGGSS DELPFELANV HFEKVGESYI KHERLRELQE
PEVVKEEDTE KDAEAEVEVE QTDAAMAQFV EEVTNSLKVV ALNGEGGTAA VHHFTRRSES
REPIEPRISE ERESDSNDLM IPDDMRAELV EILKAYPPEP VYVNLQALRR ETEDADLAIA
QAEAAALAAA EPAKKPLQCP TIEFEPPSRR SSFDPPRSPF LEQLRSPGVD TETDLINLQR
LDSGGDSFEL VESKWSKSSR GESSFDCPYS SRDTSFDVSI SRYQSTSYED QTSSFEIVDT
DEKGQGRRAV DLRKSSIELV DAETFQRSGS SCGGRKSSLE THFDYTPTEG GGRSPSLPFP
AMSKKQRTEN FRQLHVSQFS AFSRARSPLS QQTSSNYSSR DSYDSSGSYP HGYGYPPEPQ
RSPYGDPSRK HFPLTVRQKG EEEREVRTFL CTDQRCASIF EPRPSSVLTQ QLSTGSMSTP
SGYTNGTPRI PGAAPVGPVP LPHPSAPLSS CGFSSGSEFE PPSPRRAASA SPKHTFTFRI
VMKKVDSSPE ALCPERHRSR IIDRYRRRDS RRKRIHDAGK SF
