ID   GPRX_ORYLA              Reviewed;         428 AA.
AC   Q91178;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable G-protein coupled receptor;
DE   Flags: Fragment;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7756357; DOI=10.1016/0005-2736(95)80037-g;
RA   Yasuoka A., Abe K., Saigo K., Arai S., Emori Y.;
RT   "Molecular cloning of a fish gene encoding a novel seven-transmembrane
RT   receptor related distantly to catecholamine, histamine, and serotonin
RT   receptors.";
RL   Biochim. Biophys. Acta 1235:467-469(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D43633; BAA07741.1; -; Genomic_DNA.
DR   PIR; I51087; I51087.
DR   AlphaFoldDB; Q91178; -.
DR   SMR; Q91178; -.
DR   STRING; 8090.ENSORLP00000000903; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..>428
FT                   /note="Probable G-protein coupled receptor"
FT                   /id="PRO_0000069661"
FT   TOPO_DOM        1..46
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..210
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..293
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..>428
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          398..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         428
SQ   SEQUENCE   428 AA;  47259 MW;  B749E8765B58A38F CRC64;
     MMADKTSPMI TSDHSISNFS TGLFGPHPTV PPDVGVVTSS QSQMKDLFGL FCMVTLNLIA
     LLANTGVMVA IARAPHLKKF AFVCHLCAVD VLCAILLMPL GIISSSPFFG TVVFTILECQ
     VYIFLNVFLI WLSILTITAI SVERYFYIVH PMRYEVKMTI NLVIGVMLLI WFKSLLLALV
     TLFGWPPYGH QSSIAASHCS LHASHSRLRG VFAVLFCVIC FLAPVVVIFS VYSAVYKVAR
     SAALQQVPAV PTWADASPAK DRSDSINSQT TIITTRTLPQ RLSPERAFSG GKAALTLAFI
     VGQFLVCWLP FFIFHLQMSL TGSMKSPGDL EEAVNWLAYS SFAVNPSFYG LLNRQIRDEL
     VKFRRCCVTQ PVEIGPSSLE GSFQENFLQF IQRTSSSSET HPSFANSNPR NMENQAHKIP
     GQIPEEQA