ID   GPSB_STRR6              Reviewed;         109 AA.
AC   Q8DR57;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Cell cycle protein GpsB {ECO:0000255|HAMAP-Rule:MF_02011};
DE   AltName: Full=Guiding PBP1-shuttling protein {ECO:0000255|HAMAP-Rule:MF_02011};
GN   Name=gpsB {ECO:0000255|HAMAP-Rule:MF_02011}; OrderedLocusNames=spr0332;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Divisome component that associates with the complex late in
CC       its assembly, after the Z-ring is formed, and is dependent on DivIC and
CC       PBP2B for its recruitment to the divisome. Together with EzrA, is a key
CC       component of the system that regulates PBP1 localization during cell
CC       cycle progression. Its main role could be the removal of PBP1 from the
CC       cell pole after pole maturation is completed. Also contributes to the
CC       recruitment of PBP1 to the division complex. Not essential for septum
CC       formation. {ECO:0000255|HAMAP-Rule:MF_02011}.
CC   -!- SUBUNIT: Forms polymers through the coiled coil domains. Interacts with
CC       PBP1, MreC and EzrA. {ECO:0000255|HAMAP-Rule:MF_02011}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02011}.
CC       Note=Shuttles between the lateral wall and the division site in a cell
CC       cycle-dependent manner. {ECO:0000255|HAMAP-Rule:MF_02011}.
CC   -!- SIMILARITY: Belongs to the GpsB family. {ECO:0000255|HAMAP-
CC       Rule:MF_02011}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK99136.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE007317; AAK99136.1; ALT_INIT; Genomic_DNA.
DR   PIR; D97913; D97913.
DR   RefSeq; NP_357926.1; NC_003098.1.
DR   RefSeq; WP_000146522.1; NC_003098.1.
DR   PDB; 6GQA; X-ray; 1.90 A; A/B/C/D=4-63.
DR   PDB; 6GQN; X-ray; 1.80 A; A/B=4-63.
DR   PDBsum; 6GQA; -.
DR   PDBsum; 6GQN; -.
DR   AlphaFoldDB; Q8DR57; -.
DR   SMR; Q8DR57; -.
DR   BioGRID; 4182179; 6.
DR   STRING; 171101.spr0332; -.
DR   EnsemblBacteria; AAK99136; AAK99136; spr0332.
DR   GeneID; 60233532; -.
DR   KEGG; spr:spr0332; -.
DR   PATRIC; fig|171101.6.peg.371; -.
DR   eggNOG; COG3599; Bacteria.
DR   HOGENOM; CLU_140309_1_0_9; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02011; GpsB; 1.
DR   InterPro; IPR011229; Cell_cycle_GpsB.
DR   InterPro; IPR019933; DivIVA_domain.
DR   InterPro; IPR007793; DivIVA_fam.
DR   PANTHER; PTHR35794; PTHR35794; 1.
DR   PANTHER; PTHR35794:SF1; PTHR35794:SF1; 1.
DR   Pfam; PF05103; DivIVA; 1.
DR   PIRSF; PIRSF029938; UCP029938; 1.
DR   TIGRFAMs; TIGR03544; DivI1A_domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Cell shape; Coiled coil;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..109
FT                   /note="Cell cycle protein GpsB"
FT                   /id="PRO_0000337954"
FT   COILED          36..63
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02011"
FT   HELIX           8..13
FT                   /evidence="ECO:0007829|PDB:6GQN"
FT   STRAND          21..23
FT                   /evidence="ECO:0007829|PDB:6GQN"
FT   HELIX           25..60
FT                   /evidence="ECO:0007829|PDB:6GQN"
SQ   SEQUENCE   109 AA;  12575 MW;  F384A365F2BE2CA4 CRC64;
     MASIIFSAKD IFEQEFGREV RGYNKVEVDE FLDDVIKDYE TYAALVKSLR QEIADLKEEL
     TRKPKPSPVQ AEPLEAAITS SMTNFDILKR LNRLEKEVFG KQILDNSDF