GPT11_HUMAN
ID GPT11_HUMAN Reviewed; 285 AA.
AC Q8N954; A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=G patch domain-containing protein 11;
DE AltName: Full=Coiled-coil domain-containing protein 75;
GN Name=GPATCH11; Synonyms=CCDC75, CENP-Y {ECO:0000303|PubMed:20813266};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 8-285 (ISOFORM 1).
RC TISSUE=Brain, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-149, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L., Wood L.,
RA Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P., Fukagawa T.,
RA Earnshaw W.C., Rappsilber J.;
RT "The protein composition of mitotic chromosomes determined using
RT multiclassifier combinatorial proteomics.";
RL Cell 142:810-821(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8N954; O60242: ADGRB3; NbExp=3; IntAct=EBI-2555378, EBI-2682765;
CC Q8N954; O00560: SDCBP; NbExp=3; IntAct=EBI-2555378, EBI-727004;
CC Q8N954-2; P35659: DEK; NbExp=3; IntAct=EBI-12178961, EBI-301977;
CC Q8N954-2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-12178961, EBI-79165;
CC Q8N954-2; O00560: SDCBP; NbExp=3; IntAct=EBI-12178961, EBI-727004;
CC Q8N954-2; Q6S9Z5: ZNF474; NbExp=3; IntAct=EBI-12178961, EBI-17269964;
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000269|PubMed:20813266}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N954-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N954-2; Sequence=VSP_023505, VSP_023506;
CC -!- SIMILARITY: Belongs to the GPATCH11 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-27 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH11850.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK095667; BAC04602.1; -; mRNA.
DR EMBL; AK289504; BAF82193.1; -; mRNA.
DR EMBL; AK294697; BAH11850.1; ALT_INIT; mRNA.
DR EMBL; AC007899; AAY24316.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00410.1; -; Genomic_DNA.
DR EMBL; BC071798; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS62891.1; -. [Q8N954-2]
DR RefSeq; NP_001265434.1; NM_001278505.1. [Q8N954-2]
DR RefSeq; NP_001309178.1; NM_001322249.1.
DR RefSeq; NP_777591.3; NM_174931.3.
DR RefSeq; XP_016859237.1; XM_017003748.1.
DR AlphaFoldDB; Q8N954; -.
DR BioGRID; 128977; 44.
DR IntAct; Q8N954; 21.
DR MINT; Q8N954; -.
DR STRING; 9606.ENSP00000386772; -.
DR iPTMnet; Q8N954; -.
DR PhosphoSitePlus; Q8N954; -.
DR BioMuta; GPATCH11; -.
DR DMDM; 294862520; -.
DR EPD; Q8N954; -.
DR jPOST; Q8N954; -.
DR MassIVE; Q8N954; -.
DR MaxQB; Q8N954; -.
DR PaxDb; Q8N954; -.
DR PeptideAtlas; Q8N954; -.
DR PRIDE; Q8N954; -.
DR ProteomicsDB; 72488; -. [Q8N954-1]
DR ProteomicsDB; 72489; -. [Q8N954-2]
DR Antibodypedia; 52371; 125 antibodies from 15 providers.
DR DNASU; 253635; -.
DR Ensembl; ENST00000409774.6; ENSP00000386772.2; ENSG00000152133.16. [Q8N954-1]
DR GeneID; 253635; -.
DR KEGG; hsa:253635; -.
DR UCSC; uc002rpr.6; human. [Q8N954-1]
DR CTD; 253635; -.
DR GeneCards; GPATCH11; -.
DR HGNC; HGNC:26768; GPATCH11.
DR HPA; ENSG00000152133; Low tissue specificity.
DR neXtProt; NX_Q8N954; -.
DR OpenTargets; ENSG00000152133; -.
DR PharmGKB; PA143485427; -.
DR VEuPathDB; HostDB:ENSG00000152133; -.
DR eggNOG; KOG1994; Eukaryota.
DR GeneTree; ENSGT00440000039029; -.
DR InParanoid; Q8N954; -.
DR OrthoDB; 1277915at2759; -.
DR PhylomeDB; Q8N954; -.
DR TreeFam; TF313583; -.
DR PathwayCommons; Q8N954; -.
DR SignaLink; Q8N954; -.
DR BioGRID-ORCS; 253635; 4 hits in 914 CRISPR screens.
DR GenomeRNAi; 253635; -.
DR Pharos; Q8N954; Tdark.
DR PRO; PR:Q8N954; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N954; protein.
DR Bgee; ENSG00000152133; Expressed in calcaneal tendon and 190 other tissues.
DR ExpressionAtlas; Q8N954; baseline and differential.
DR Genevisible; Q8N954; HS.
DR GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR InterPro; IPR025239; DUF4187.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR039249; GPATCH11.
DR PANTHER; PTHR21032; PTHR21032; 1.
DR Pfam; PF13821; DUF4187; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM01173; DUF4187; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Phosphoprotein; Reference proteome.
FT CHAIN 1..285
FT /note="G patch domain-containing protein 11"
FT /id="PRO_0000279751"
FT DOMAIN 95..141
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 59..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..87
FT /evidence="ECO:0000255"
FT COMPBIAS 218..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 141
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 149
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT VAR_SEQ 1..129
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023505"
FT VAR_SEQ 130..132
FT /note="KTG -> MSR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023506"
SQ SEQUENCE 285 AA; 33277 MW; BB24AFAA10A97F49 CRC64;
MRSARSTALN RGEQRAVRYY SHMKLNMAEE EDYMSDSFIN VQEDIRPGLP MLRQIREARR
KEEKQQEANL KNRQKSLKEE EQERRDIGLK NALGCENKGF ALLQKMGYKS GQALGKSGGG
IVEPIPLNIK TGKSGIGHEA SLKRKAEEKL ESYRKKIHMK NQAEEKAAEQ FRMRLKNKQD
EMKLEGDLRR SQRACQQLDV QKNIQVPREA WYWLRLEEET EEDEEEKEQD EDEYKSEDLS
VLEKLQILTS YLREEHLYCI WCGTAYEDKE DLSSNCPGPT SADHD
