GPT2L_HUMAN
ID GPT2L_HUMAN Reviewed; 482 AA.
AC Q9NWQ4; B3KN42; Q6PEJ7; Q9H3M3; Q9NWH0; Q9ULR8;
DT 02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=G patch domain-containing protein 2-like;
GN Name=GPATCH2L; Synonyms=C14orf118, KIAA1152;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 176-482 (ISOFORM 4).
RC TISSUE=Embryo, Ileal mucosa, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-88 AND SER-447, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-88; THR-91; SER-447
RP AND SER-449, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-196, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q9NWQ4; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-5666657, EBI-739624;
CC Q9NWQ4; Q14689: DIP2A; NbExp=3; IntAct=EBI-5666657, EBI-2564275;
CC Q9NWQ4; Q6A162: KRT40; NbExp=3; IntAct=EBI-5666657, EBI-10171697;
CC Q9NWQ4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-5666657, EBI-10172052;
CC Q9NWQ4; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-5666657, EBI-739863;
CC Q9NWQ4; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-5666657, EBI-741037;
CC Q9NWQ4; Q99750: MDFI; NbExp=3; IntAct=EBI-5666657, EBI-724076;
CC Q9NWQ4; P50222: MEOX2; NbExp=3; IntAct=EBI-5666657, EBI-748397;
CC Q9NWQ4; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-5666657, EBI-3957793;
CC Q9NWQ4; Q93062: RBPMS; NbExp=3; IntAct=EBI-5666657, EBI-740322;
CC Q9NWQ4; O43463: SUV39H1; NbExp=2; IntAct=EBI-5666657, EBI-349968;
CC Q9NWQ4; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-5666657, EBI-741515;
CC Q9NWQ4; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-5666657, EBI-725997;
CC Q9NWQ4; P10074: ZBTB48; NbExp=3; IntAct=EBI-5666657, EBI-744864;
CC Q9NWQ4; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-5666657, EBI-742740;
CC Q9NWQ4; Q53Z40: ZNF165; NbExp=3; IntAct=EBI-5666657, EBI-10186058;
CC Q9NWQ4; O14978: ZNF263; NbExp=3; IntAct=EBI-5666657, EBI-744493;
CC Q9NWQ4; Q8TD17: ZNF398; NbExp=5; IntAct=EBI-5666657, EBI-8643207;
CC Q9NWQ4; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-5666657, EBI-347633;
CC Q9NWQ4; Q8WTR7: ZNF473; NbExp=4; IntAct=EBI-5666657, EBI-751409;
CC Q9NWQ4-1; Q9NR55: BATF3; NbExp=3; IntAct=EBI-11959863, EBI-10312707;
CC Q9NWQ4-1; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11959863, EBI-3866279;
CC Q9NWQ4-1; P68400: CSNK2A1; NbExp=6; IntAct=EBI-11959863, EBI-347804;
CC Q9NWQ4-1; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11959863, EBI-3867333;
CC Q9NWQ4-1; P22607: FGFR3; NbExp=3; IntAct=EBI-11959863, EBI-348399;
CC Q9NWQ4-1; O75031: HSF2BP; NbExp=3; IntAct=EBI-11959863, EBI-7116203;
CC Q9NWQ4-1; Q92993: KAT5; NbExp=3; IntAct=EBI-11959863, EBI-399080;
CC Q9NWQ4-1; P25800: LMO1; NbExp=3; IntAct=EBI-11959863, EBI-8639312;
CC Q9NWQ4-1; Q8TAP4-4: LMO3; NbExp=6; IntAct=EBI-11959863, EBI-11742507;
CC Q9NWQ4-1; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-11959863, EBI-10268010;
CC Q9NWQ4-1; Q99750: MDFI; NbExp=3; IntAct=EBI-11959863, EBI-724076;
CC Q9NWQ4-1; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11959863, EBI-16439278;
CC Q9NWQ4-1; P41227: NAA10; NbExp=3; IntAct=EBI-11959863, EBI-747693;
CC Q9NWQ4-1; P17568: NDUFB7; NbExp=3; IntAct=EBI-11959863, EBI-1246238;
CC Q9NWQ4-1; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-11959863, EBI-350517;
CC Q9NWQ4-1; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-11959863, EBI-2876622;
CC Q9NWQ4-1; Q9UL42: PNMA2; NbExp=3; IntAct=EBI-11959863, EBI-302355;
CC Q9NWQ4-1; P62937-2: PPIA; NbExp=3; IntAct=EBI-11959863, EBI-25884072;
CC Q9NWQ4-1; P23284: PPIB; NbExp=3; IntAct=EBI-11959863, EBI-359252;
CC Q9NWQ4-1; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-11959863, EBI-3957793;
CC Q9NWQ4-1; P61289: PSME3; NbExp=3; IntAct=EBI-11959863, EBI-355546;
CC Q9NWQ4-1; P57052: RBM11; NbExp=3; IntAct=EBI-11959863, EBI-741332;
CC Q9NWQ4-1; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-11959863, EBI-9090795;
CC Q9NWQ4-1; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-11959863, EBI-5235340;
CC Q9NWQ4-1; Q9NVV9: THAP1; NbExp=5; IntAct=EBI-11959863, EBI-741515;
CC Q9NWQ4-1; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11959863, EBI-11741437;
CC Q9NWQ4-1; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-11959863, EBI-492476;
CC Q9NWQ4-1; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-11959863, EBI-725997;
CC Q9NWQ4-1; Q86WV8: TSC1; NbExp=3; IntAct=EBI-11959863, EBI-12806590;
CC Q9NWQ4-1; Q6FI91: TSPYL; NbExp=3; IntAct=EBI-11959863, EBI-723389;
CC Q9NWQ4-1; P61981: YWHAG; NbExp=3; IntAct=EBI-11959863, EBI-359832;
CC Q9NWQ4-1; O14978: ZNF263; NbExp=3; IntAct=EBI-11959863, EBI-744493;
CC Q9NWQ4-1; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11959863, EBI-11035148;
CC Q9NWQ4-1; Q8IVP9: ZNF547; NbExp=3; IntAct=EBI-11959863, EBI-12895421;
CC Q9NWQ4-1; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11959863, EBI-11962574;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NWQ4-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NWQ4-1; Sequence=VSP_014714, VSP_014716;
CC Name=4;
CC IsoId=Q9NWQ4-4; Sequence=VSP_039861;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA86466.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA91325.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA91411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB032978; BAA86466.1; ALT_INIT; mRNA.
DR EMBL; AK000696; BAA91325.1; ALT_FRAME; mRNA.
DR EMBL; AK000895; BAA91411.1; ALT_INIT; mRNA.
DR EMBL; AK023523; BAG51204.1; -; mRNA.
DR EMBL; AC016526; AAG38637.1; -; Genomic_DNA.
DR EMBL; CH471061; EAW81252.1; -; Genomic_DNA.
DR EMBL; CH471061; EAW81253.1; -; Genomic_DNA.
DR EMBL; BC058032; AAH58032.1; -; mRNA.
DR CCDS; CCDS9848.1; -. [Q9NWQ4-3]
DR CCDS; CCDS9849.1; -. [Q9NWQ4-4]
DR RefSeq; NP_060396.2; NM_017926.3. [Q9NWQ4-3]
DR RefSeq; NP_060442.2; NM_017972.3. [Q9NWQ4-4]
DR AlphaFoldDB; Q9NWQ4; -.
DR BioGRID; 120800; 66.
DR IntAct; Q9NWQ4; 67.
DR MINT; Q9NWQ4; -.
DR STRING; 9606.ENSP00000261530; -.
DR iPTMnet; Q9NWQ4; -.
DR PhosphoSitePlus; Q9NWQ4; -.
DR BioMuta; GPATCH2L; -.
DR DMDM; 308153614; -.
DR EPD; Q9NWQ4; -.
DR jPOST; Q9NWQ4; -.
DR MassIVE; Q9NWQ4; -.
DR MaxQB; Q9NWQ4; -.
DR PaxDb; Q9NWQ4; -.
DR PeptideAtlas; Q9NWQ4; -.
DR PRIDE; Q9NWQ4; -.
DR ProteomicsDB; 82958; -. [Q9NWQ4-3]
DR ProteomicsDB; 82959; -. [Q9NWQ4-1]
DR ProteomicsDB; 82960; -. [Q9NWQ4-4]
DR Antibodypedia; 109; 24 antibodies from 10 providers.
DR DNASU; 55668; -.
DR Ensembl; ENST00000261530.12; ENSP00000261530.7; ENSG00000089916.18. [Q9NWQ4-3]
DR Ensembl; ENST00000312858.9; ENSP00000323775.5; ENSG00000089916.18. [Q9NWQ4-4]
DR Ensembl; ENST00000556663.5; ENSP00000450657.1; ENSG00000089916.18. [Q9NWQ4-1]
DR Ensembl; ENST00000557263.5; ENSP00000451587.1; ENSG00000089916.18. [Q9NWQ4-1]
DR Ensembl; ENST00000621494.1; ENSP00000480608.1; ENSG00000089916.18. [Q9NWQ4-4]
DR GeneID; 55668; -.
DR KEGG; hsa:55668; -.
DR MANE-Select; ENST00000261530.12; ENSP00000261530.7; NM_017926.4; NP_060396.2.
DR UCSC; uc001xsh.5; human. [Q9NWQ4-3]
DR CTD; 55668; -.
DR DisGeNET; 55668; -.
DR GeneCards; GPATCH2L; -.
DR HGNC; HGNC:20210; GPATCH2L.
DR HPA; ENSG00000089916; Low tissue specificity.
DR neXtProt; NX_Q9NWQ4; -.
DR OpenTargets; ENSG00000089916; -.
DR PharmGKB; PA134963976; -.
DR VEuPathDB; HostDB:ENSG00000089916; -.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00410000025698; -.
DR HOGENOM; CLU_041240_0_1_1; -.
DR InParanoid; Q9NWQ4; -.
DR OMA; YQRDFWL; -.
DR OrthoDB; 606839at2759; -.
DR PhylomeDB; Q9NWQ4; -.
DR TreeFam; TF331954; -.
DR PathwayCommons; Q9NWQ4; -.
DR SignaLink; Q9NWQ4; -.
DR BioGRID-ORCS; 55668; 10 hits in 1079 CRISPR screens.
DR ChiTaRS; GPATCH2L; human.
DR GenomeRNAi; 55668; -.
DR Pharos; Q9NWQ4; Tdark.
DR PRO; PR:Q9NWQ4; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NWQ4; protein.
DR Bgee; ENSG00000089916; Expressed in buccal mucosa cell and 171 other tissues.
DR ExpressionAtlas; Q9NWQ4; baseline and differential.
DR Genevisible; Q9NWQ4; HS.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..482
FT /note="G patch domain-containing protein 2-like"
FT /id="PRO_0000089927"
FT REGION 198..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 91
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 447
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 449
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CROSSLNK 196
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 329..351
FT /note="ETSINTLGTERISHIISDPRQKE -> VIPLTVSLAQWGDNIPYGSCVSY
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10574461,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_014714"
FT VAR_SEQ 351..369
FT /note="EKNKALASDFPHISACAHE -> DFWLPSAGKRERNQ (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039861"
FT VAR_SEQ 352..482
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10574461,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_014716"
FT VARIANT 132
FT /note="V -> E (in dbSNP:rs17104086)"
FT /id="VAR_056838"
FT CONFLICT 187
FT /note="S -> L (in Ref. 2; BAA91325)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="R -> G (in Ref. 2; BAA91325)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="D -> V (in Ref. 2; BAA91411)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 54260 MW; 1BA1C5B38DC6373E CRC64;
MDELVHDLAS ALEQTSEQNK LGELWEEMAL SPRQQRRQLR KRRGRKRRSD FTHLAEHTCC
YSEASESSLD EATKDCREVA PVTNFSDSDD TMVAKRHPAL NAIVKSKQHS WHESDSFTEN
APCRPLRRRR KVKRVTSEVA ASLQQKLKVS DWSYERGCRF KSAKKQRLSR WKENTPWTSS
GHGLCESAEN RTFLSKTGRK ERMECETDEQ KQGSDENMSE CETSSVCSSS DTGLFTNDEG
RQGDDEQSDW FYEGECVPGF TVPNLLPKWA PDHCSEVERM DSGLDKFSDS TFLLPSRPAQ
RGYHTRLNRL PGAAARCLRK GRRRLVGKET SINTLGTERI SHIISDPRQK EKNKALASDF
PHISACAHEF NPLSPLYSLD VLADASHRRC SPAHCSARQA NVHWGPPCSR DIKRKRKPVA
TASLSSPSAV HMDAVEPTTP ASQAPKSPSS EWLVRTSAAE KATDATTATF FKMPQEKSPG
YS