GPT2L_MOUSE
ID GPT2L_MOUSE Reviewed; 482 AA.
AC Q6PE65; Q6ZPW9; Q8CD08; Q9DA49;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=G patch domain-containing protein 2-like;
GN Name=Gpatch2l; Synonyms=Kiaa1152;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryonic testis, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-86 AND SER-88, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PE65-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PE65-2; Sequence=VSP_014717;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98109.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK006185; BAB24446.1; -; mRNA.
DR EMBL; AK031712; BAC27527.1; -; mRNA.
DR EMBL; AK129299; BAC98109.1; ALT_INIT; mRNA.
DR EMBL; BC048169; AAH48169.1; -; mRNA.
DR EMBL; BC058256; AAH58256.1; -; mRNA.
DR CCDS; CCDS26065.1; -. [Q6PE65-1]
DR CCDS; CCDS88376.1; -. [Q6PE65-2]
DR RefSeq; NP_001311417.1; NM_001324488.1. [Q6PE65-2]
DR RefSeq; NP_081681.2; NM_027405.3. [Q6PE65-1]
DR AlphaFoldDB; Q6PE65; -.
DR BioGRID; 214009; 1.
DR STRING; 10090.ENSMUSP00000065858; -.
DR iPTMnet; Q6PE65; -.
DR PhosphoSitePlus; Q6PE65; -.
DR jPOST; Q6PE65; -.
DR MaxQB; Q6PE65; -.
DR PaxDb; Q6PE65; -.
DR PRIDE; Q6PE65; -.
DR ProteomicsDB; 271079; -. [Q6PE65-1]
DR ProteomicsDB; 271080; -. [Q6PE65-2]
DR Antibodypedia; 109; 24 antibodies from 10 providers.
DR DNASU; 70373; -.
DR Ensembl; ENSMUST00000071106; ENSMUSP00000065858; ENSMUSG00000021254. [Q6PE65-2]
DR Ensembl; ENSMUST00000221368; ENSMUSP00000152284; ENSMUSG00000021254. [Q6PE65-1]
DR GeneID; 70373; -.
DR KEGG; mmu:70373; -.
DR UCSC; uc007ohr.1; mouse. [Q6PE65-1]
DR UCSC; uc007ohs.1; mouse. [Q6PE65-2]
DR CTD; 55668; -.
DR MGI; MGI:1917623; Gpatch2l.
DR VEuPathDB; HostDB:ENSMUSG00000021254; -.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00410000025698; -.
DR HOGENOM; CLU_041240_0_1_1; -.
DR InParanoid; Q6PE65; -.
DR OMA; YQRDFWL; -.
DR OrthoDB; 606839at2759; -.
DR PhylomeDB; Q6PE65; -.
DR TreeFam; TF331954; -.
DR BioGRID-ORCS; 70373; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Gpatch2l; mouse.
DR PRO; PR:Q6PE65; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q6PE65; protein.
DR Bgee; ENSMUSG00000021254; Expressed in lumbar subsegment of spinal cord and 226 other tissues.
DR Genevisible; Q6PE65; MM.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..482
FT /note="G patch domain-containing protein 2-like"
FT /id="PRO_0000089928"
FT REGION 195..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 91
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWQ4"
FT VAR_SEQ 393..482
FT /note="RQASVHWGPPCPRDIKRKRKPVASASFSSPSPVHPDVLEPAIPAQKPPDSEW
FT LDGTSAAEKATAFPPATFFKMPQEKNSGCSSSPGTNGC -> SAPRCSGAGHPSSEAS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014717"
FT CONFLICT 7
FT /note="D -> E (in Ref. 1; BAB24446)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="H -> N (in Ref. 1; BAB24446)"
FT /evidence="ECO:0000305"
FT CONFLICT 344
FT /note="I -> N (in Ref. 1; BAB24446)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 53989 MW; 404EFD55500E4B89 CRC64;
MDELVHDLAS ALEQTSEQSK LGELWEEMAL SPRQQRRQLR KRRGRKRRSD FTHLAEHACC
FSEASESSLD EATKDCREVA PLTNFSDSDD TVVAKRHPAL SAIIRGKQHS WPESDSFTEN
APCRPLRRRR KVKRVTSEVA ASLQQKLKVS DWSYERGCRF KSAKKQRLSR WKENTPWTSS
GHGLCESAEN RTFLSQPGRK ERMECEAEEQ KHGSDENMSE CDTSSVCSSS DTGLFTNDEG
RQGDDEQSDW FYEGECVPGF TVHNLLPKWA PDHCTEVERM DSGLDKLSDP TFLLPSRPAQ
RGYHGRLNRL PGAAARCLRK GRRRLPGKEA SMSSLGTERI GHTISDPRQT DFWLPSAGKR
ERNQFNPLSP LYSLDVLADA SHRRCSPAHC SARQASVHWG PPCPRDIKRK RKPVASASFS
SPSPVHPDVL EPAIPAQKPP DSEWLDGTSA AEKATAFPPA TFFKMPQEKN SGCSSSPGTN
GC
