GPTC1_DROME
ID GPTC1_DROME Reviewed; 952 AA.
AC Q9VUA0; C1C3H2; Q95RM7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=G patch domain-containing protein 1 homolog;
GN ORFNames=CG8833;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Sandler J., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-952.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the GPATCH1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28820.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014296; AAF49789.1; -; Genomic_DNA.
DR EMBL; BT081401; ACO51532.1; -; mRNA.
DR EMBL; AY061272; AAL28820.1; ALT_INIT; mRNA.
DR RefSeq; NP_648669.1; NM_140412.2.
DR AlphaFoldDB; Q9VUA0; -.
DR BioGRID; 64876; 2.
DR IntAct; Q9VUA0; 6.
DR STRING; 7227.FBpp0075534; -.
DR PaxDb; Q9VUA0; -.
DR PRIDE; Q9VUA0; -.
DR EnsemblMetazoa; FBtr0075792; FBpp0075534; FBgn0036386.
DR GeneID; 39535; -.
DR KEGG; dme:Dmel_CG8833; -.
DR UCSC; CG8833-RA; d. melanogaster.
DR FlyBase; FBgn0036386; CG8833.
DR VEuPathDB; VectorBase:FBgn0036386; -.
DR eggNOG; KOG2138; Eukaryota.
DR GeneTree; ENSGT00390000007074; -.
DR HOGENOM; CLU_008613_1_0_1; -.
DR InParanoid; Q9VUA0; -.
DR OMA; QLWQQHA; -.
DR OrthoDB; 1175081at2759; -.
DR PhylomeDB; Q9VUA0; -.
DR BioGRID-ORCS; 39535; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 39535; -.
DR PRO; PR:Q9VUA0; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036386; Expressed in ovary and 24 other tissues.
DR Genevisible; Q9VUA0; DM.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; HDA:FlyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IC:FlyBase.
DR InterPro; IPR011666; DUF1604.
DR InterPro; IPR000467; G_patch_dom.
DR Pfam; PF07713; DUF1604; 1.
DR Pfam; PF01585; G-patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..952
FT /note="G patch domain-containing protein 1 homolog"
FT /id="PRO_0000287460"
FT DOMAIN 153..199
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 104..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..229
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..952
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 952 AA; 107899 MW; CCB599A3D8A06F44 CRC64;
MDEEEHLHRF GTPLPALQKD VVPAKKPVAI EDQIVKDENG KRRFHGAFTG GFSAGFWNTV
GSLEGWTPQT FKSSRGERAS SKAQLKPEDF MDQEDLGEFG IAPQGIRTRD EFANEDEQKQ
RSDQRRRKLM QPELGVGAIP GLPVLEQLLR PVRDKVAVRI LKSMGWKPGQ GVGPRQTRKE
KRQATARNSK EQYLMEHYGA EGLPSNKENK GEEDSNNEDE DDEDITFAPD DYEPIFYTPK
ENRFGMSYSG LNRDPILSKS SSSSAKPMQH INLFGEMEAQ ANKKQLSIRG QAFGVGAFEE
EDEDIYARDD MTRYDFSLAD KKPKQKKQQH VQQRHVIDGF SEDNSPAVLQ RPYAIDLPRD
FQPRNWLQRR SRFAPMDKER AQKLETASEY KRSGLGRHDL NPDQRAQILG EQQQEEKTAE
EQPKRNPFKD HSKSLMERIN ARTEGFTKGG VITENGEEQQ TELAKEVKEA NAAIQERAAL
KTKDLPSAMN SSSAFKPFIA DEAKQLRYEK FVSSKLTDDK EITEFLARMQ PVTLSLWDRE
MEKKEFIQAA KIYRPLVGLM NDRFVSEANV QAEKVEQQEK PPEERKIVME RTKTMWKPTA
LLCKRYNIAE PFGGAMLEPE KELKAKAKIS VFDYLETSVN TKANFETPSI FPKHIEKSIP
EKVETPPSPP PAPQPEAEIQ DKPNTKEEPS KHTFVPKTPL EQAVDESRNK PISEKVDLFK
SIFEDSDEEE TELSEQDKLA ILQESFGLPV TSTTSAAAQN VLRNTSPPRG IFASLFSPKI
KDAAKEPAPT KFGPIEGSKL KIAYKPRKER LRNDRELAMA EVAPEDIYGP KLPTAPPQKP
AAPEIQAEAN IDDRLQQLWQ QHAPKKRKAE KWVEKKCISG SEDSDASSSN ESSSSDSSDD
NDKRSKLSKP KKSHKGSSSK KSKKSKLKSK KKSKKSEESK HKAKKKKKKS KH
