GPTC1_MOUSE
ID GPTC1_MOUSE Reviewed; 930 AA.
AC Q9DBM1; Q8R0V4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=G patch domain-containing protein 1;
GN Name=Gpatch1; Synonyms=Gpatc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Brain, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the GPATCH1 family. {ECO:0000305}.
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DR EMBL; AK004868; BAB23629.1; -; mRNA.
DR EMBL; BC026394; AAH26394.1; -; mRNA.
DR EMBL; BC132155; AAI32156.1; -; mRNA.
DR EMBL; BC125584; AAI25585.1; -; mRNA.
DR CCDS; CCDS21147.1; -.
DR RefSeq; NP_080457.1; NM_026181.1.
DR AlphaFoldDB; Q9DBM1; -.
DR BioGRID; 212213; 8.
DR STRING; 10090.ENSMUSP00000078632; -.
DR iPTMnet; Q9DBM1; -.
DR PhosphoSitePlus; Q9DBM1; -.
DR EPD; Q9DBM1; -.
DR MaxQB; Q9DBM1; -.
DR PaxDb; Q9DBM1; -.
DR PRIDE; Q9DBM1; -.
DR ProteomicsDB; 271010; -.
DR Antibodypedia; 28992; 21 antibodies from 8 providers.
DR DNASU; 67471; -.
DR Ensembl; ENSMUST00000079693; ENSMUSP00000078632; ENSMUSG00000063808.
DR GeneID; 67471; -.
DR KEGG; mmu:67471; -.
DR UCSC; uc009gjq.1; mouse.
DR CTD; 55094; -.
DR MGI; MGI:1914721; Gpatch1.
DR VEuPathDB; HostDB:ENSMUSG00000063808; -.
DR eggNOG; KOG2138; Eukaryota.
DR GeneTree; ENSGT00390000007074; -.
DR InParanoid; Q9DBM1; -.
DR OMA; QLWQQHA; -.
DR OrthoDB; 1175081at2759; -.
DR PhylomeDB; Q9DBM1; -.
DR TreeFam; TF314717; -.
DR BioGRID-ORCS; 67471; 13 hits in 72 CRISPR screens.
DR PRO; PR:Q9DBM1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9DBM1; protein.
DR Bgee; ENSMUSG00000063808; Expressed in dorsal pancreas and 245 other tissues.
DR ExpressionAtlas; Q9DBM1; baseline and differential.
DR Genevisible; Q9DBM1; MM.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR011666; DUF1604.
DR InterPro; IPR000467; G_patch_dom.
DR Pfam; PF07713; DUF1604; 1.
DR Pfam; PF01585; G-patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT CHAIN 2..930
FT /note="G patch domain-containing protein 1"
FT /id="PRO_0000287458"
FT DOMAIN 152..198
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..887
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT MOD_RES 358
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT MOD_RES 715
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT CROSSLNK 313
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT CONFLICT 373
FT /note="R -> Q (in Ref. 2; AAH26394)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 930 AA; 103008 MW; 62D383B72424EF73 CRC64;
MAALDSDSDE DLISYGTGLE PLDEGERPKK PIPLQDQTVR DEKGRYKRFH GAFSGGFSAG
YFNTVGSKEG WTPSTFVSSR QNRADKSALG PEDFMDEEDL SEFGIAPKAI VTTDDFASKT
KDRIREKARQ LAAAAAPIPG ATLLDDLITP AKLSVGFELL RKMGWKEGQG VGPRVKRKAR
RQKPDPGVKI YGCALPPGGS EESEDEDDDY LPDNVTFAPK DVMPVDFTPK DNVHGLAYKG
LDPHQALFGM PGEHLNLFGG ASEGTSHLLG DVGLSKGRKL GISGQAFGVG ALEEEDDDIY
ATETLSKYDT VLKDEEPGDG LYGWTAPKQY KNQKEPERDL RYVGKILEGF SLASKPLSSK
KIYPPPQLPR DYRPVHYFRP VVAATAENAH VLQVLSESSG KAGQDVGTHS RHQLNASKRG
ELLGEMPIQG SATSVLEFLS QKDKERIKEV KQATDLKAAQ AKARSLAQSA SSSRAQASTP
DLGHSSWHLA LGGGTVTTRA NNFKPFAKDP EKQRRYEEFL VHMKKGQKDA LERCLDPSMT
EWERSREREE FARAAQLYVS SNSTLSSRFT HAKEEEDSDQ VEVPRDQEND VSDKQSAVKM
KMFGKLTRDT FEWHPDKLLC KRFNVPDPYP GSTLVGLPRV KRDKYSVFNF LTLPEPAPLP
TAPVPSEKAP QQRGSDKSRK PSRWDTSKQE KKEDSISEFL SQARSKVGPP KQESSALGSK
EEQAPEPRPD TTVDKAVDAQ TDGEGSRPSM DLFKAIFASS SDEKSSSSEE EQDDSEDSQE
HTEEASLKGS QEAAAGETSV VLAAEPEPCE PATPFPIQKA QIDEREEFGP RLPPVFCPNS
RQKLEIPQKE KPKKSKERHK SKKEHRRKRE KKKKHKKHKH KSKQKNKKSE KNSSSESTDS
SDSGSDDGGP AELSPQELLR RLKCLPLRRQ