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GPTC1_MOUSE
ID   GPTC1_MOUSE             Reviewed;         930 AA.
AC   Q9DBM1; Q8R0V4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=G patch domain-containing protein 1;
GN   Name=Gpatch1; Synonyms=Gpatc1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Brain, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the GPATCH1 family. {ECO:0000305}.
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DR   EMBL; AK004868; BAB23629.1; -; mRNA.
DR   EMBL; BC026394; AAH26394.1; -; mRNA.
DR   EMBL; BC132155; AAI32156.1; -; mRNA.
DR   EMBL; BC125584; AAI25585.1; -; mRNA.
DR   CCDS; CCDS21147.1; -.
DR   RefSeq; NP_080457.1; NM_026181.1.
DR   AlphaFoldDB; Q9DBM1; -.
DR   BioGRID; 212213; 8.
DR   STRING; 10090.ENSMUSP00000078632; -.
DR   iPTMnet; Q9DBM1; -.
DR   PhosphoSitePlus; Q9DBM1; -.
DR   EPD; Q9DBM1; -.
DR   MaxQB; Q9DBM1; -.
DR   PaxDb; Q9DBM1; -.
DR   PRIDE; Q9DBM1; -.
DR   ProteomicsDB; 271010; -.
DR   Antibodypedia; 28992; 21 antibodies from 8 providers.
DR   DNASU; 67471; -.
DR   Ensembl; ENSMUST00000079693; ENSMUSP00000078632; ENSMUSG00000063808.
DR   GeneID; 67471; -.
DR   KEGG; mmu:67471; -.
DR   UCSC; uc009gjq.1; mouse.
DR   CTD; 55094; -.
DR   MGI; MGI:1914721; Gpatch1.
DR   VEuPathDB; HostDB:ENSMUSG00000063808; -.
DR   eggNOG; KOG2138; Eukaryota.
DR   GeneTree; ENSGT00390000007074; -.
DR   InParanoid; Q9DBM1; -.
DR   OMA; QLWQQHA; -.
DR   OrthoDB; 1175081at2759; -.
DR   PhylomeDB; Q9DBM1; -.
DR   TreeFam; TF314717; -.
DR   BioGRID-ORCS; 67471; 13 hits in 72 CRISPR screens.
DR   PRO; PR:Q9DBM1; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9DBM1; protein.
DR   Bgee; ENSMUSG00000063808; Expressed in dorsal pancreas and 245 other tissues.
DR   ExpressionAtlas; Q9DBM1; baseline and differential.
DR   Genevisible; Q9DBM1; MM.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   InterPro; IPR011666; DUF1604.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF07713; DUF1604; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   CHAIN           2..930
FT                   /note="G patch domain-containing protein 1"
FT                   /id="PRO_0000287458"
FT   DOMAIN          152..198
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          654..930
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..595
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        672..699
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        723..741
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        853..887
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   MOD_RES         8
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   MOD_RES         358
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   MOD_RES         715
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   CROSSLNK        313
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRR8"
FT   CONFLICT        373
FT                   /note="R -> Q (in Ref. 2; AAH26394)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   930 AA;  103008 MW;  62D383B72424EF73 CRC64;
     MAALDSDSDE DLISYGTGLE PLDEGERPKK PIPLQDQTVR DEKGRYKRFH GAFSGGFSAG
     YFNTVGSKEG WTPSTFVSSR QNRADKSALG PEDFMDEEDL SEFGIAPKAI VTTDDFASKT
     KDRIREKARQ LAAAAAPIPG ATLLDDLITP AKLSVGFELL RKMGWKEGQG VGPRVKRKAR
     RQKPDPGVKI YGCALPPGGS EESEDEDDDY LPDNVTFAPK DVMPVDFTPK DNVHGLAYKG
     LDPHQALFGM PGEHLNLFGG ASEGTSHLLG DVGLSKGRKL GISGQAFGVG ALEEEDDDIY
     ATETLSKYDT VLKDEEPGDG LYGWTAPKQY KNQKEPERDL RYVGKILEGF SLASKPLSSK
     KIYPPPQLPR DYRPVHYFRP VVAATAENAH VLQVLSESSG KAGQDVGTHS RHQLNASKRG
     ELLGEMPIQG SATSVLEFLS QKDKERIKEV KQATDLKAAQ AKARSLAQSA SSSRAQASTP
     DLGHSSWHLA LGGGTVTTRA NNFKPFAKDP EKQRRYEEFL VHMKKGQKDA LERCLDPSMT
     EWERSREREE FARAAQLYVS SNSTLSSRFT HAKEEEDSDQ VEVPRDQEND VSDKQSAVKM
     KMFGKLTRDT FEWHPDKLLC KRFNVPDPYP GSTLVGLPRV KRDKYSVFNF LTLPEPAPLP
     TAPVPSEKAP QQRGSDKSRK PSRWDTSKQE KKEDSISEFL SQARSKVGPP KQESSALGSK
     EEQAPEPRPD TTVDKAVDAQ TDGEGSRPSM DLFKAIFASS SDEKSSSSEE EQDDSEDSQE
     HTEEASLKGS QEAAAGETSV VLAAEPEPCE PATPFPIQKA QIDEREEFGP RLPPVFCPNS
     RQKLEIPQKE KPKKSKERHK SKKEHRRKRE KKKKHKKHKH KSKQKNKKSE KNSSSESTDS
     SDSGSDDGGP AELSPQELLR RLKCLPLRRQ
 
 
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