GPTC3_MOUSE
ID GPTC3_MOUSE Reviewed; 525 AA.
AC Q8BIY1; A2A9E8;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=G patch domain-containing protein 3;
GN Name=Gpatch3; Synonyms=Gpatc3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Involved in transcriptional regulation. It is able to
CC activate transcription from CXCR4 promoter and therefore it might
CC control neural crest cell migration involved in ocular and craniofacial
CC development. Is a negative regulator of immune antiviral response,
CC acting via down-regulation of RIG-I-like receptors signaling and
CC inhibition of type I interferon production. The control mechanism
CC involves interaction with mitochondrial MAVS and inhibition of MAVS
CC assembly with downstream proteins implicated in antiviral response,
CC such as TBK1 and TRAF6. {ECO:0000250|UniProtKB:Q96I76}.
CC -!- SUBUNIT: Interacts with mitochondrial MAVS; the interaction is markedly
CC increased upon viral infection. {ECO:0000250|UniProtKB:Q96I76}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96I76}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q96I76}.
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DR EMBL; AK053051; BAC35250.1; -; mRNA.
DR EMBL; AL627228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18752.1; -.
DR RefSeq; NP_766464.1; NM_172876.2.
DR AlphaFoldDB; Q8BIY1; -.
DR BioGRID; 232444; 1.
DR STRING; 10090.ENSMUSP00000030662; -.
DR iPTMnet; Q8BIY1; -.
DR PhosphoSitePlus; Q8BIY1; -.
DR EPD; Q8BIY1; -.
DR MaxQB; Q8BIY1; -.
DR PaxDb; Q8BIY1; -.
DR PRIDE; Q8BIY1; -.
DR ProteomicsDB; 271155; -.
DR Antibodypedia; 35286; 34 antibodies from 13 providers.
DR DNASU; 242691; -.
DR Ensembl; ENSMUST00000030662; ENSMUSP00000030662; ENSMUSG00000028850.
DR GeneID; 242691; -.
DR KEGG; mmu:242691; -.
DR UCSC; uc008vda.1; mouse.
DR CTD; 63906; -.
DR MGI; MGI:2442492; Gpatch3.
DR VEuPathDB; HostDB:ENSMUSG00000028850; -.
DR eggNOG; ENOG502QQ66; Eukaryota.
DR GeneTree; ENSGT00390000004191; -.
DR HOGENOM; CLU_025388_0_0_1; -.
DR InParanoid; Q8BIY1; -.
DR OMA; FPYKTKY; -.
DR OrthoDB; 1238918at2759; -.
DR PhylomeDB; Q8BIY1; -.
DR TreeFam; TF314766; -.
DR BioGRID-ORCS; 242691; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Gpatch3; mouse.
DR PRO; PR:Q8BIY1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BIY1; protein.
DR Bgee; ENSMUSG00000028850; Expressed in cleaving embryo and 114 other tissues.
DR Genevisible; Q8BIY1; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0039536; P:negative regulation of RIG-I signaling pathway; ISO:MGI.
DR GO; GO:0032480; P:negative regulation of type I interferon production; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR040341; GPATCH3.
DR PANTHER; PTHR14390; PTHR14390; 1.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..525
FT /note="G patch domain-containing protein 3"
FT /id="PRO_0000087569"
FT DOMAIN 411..459
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 54..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..299
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 59180 MW; F963C4FED03C934E CRC64;
MASPRELDEE SPVYLVVSGI PAVLRSAQLR SYFSQFREQR GGGFLCFHYR HRPERGPPQA
SPEAARAGPD PAAEDPVLAQ APASDARAVR ARGSAAAQTR TCCCVVSVRG AAQAQRLLRM
YSGRRWLDSQ GTWLPGRCLI RRLRLPTEVS DLGSFPFKTR KELQSRRAEN EAFTLADLKQ
LPELNPPVLM PNGNVGTPLR VFLELIRSCR LPPRIITQLQ LQFPKTGSSR RYGNVPFLYE
DSETVEQEEH VYTAEGEEIP QGSCSEDPAA GSFDEPEDEG QQQEEEEESG SEEDDDRGEE
WERHEALHED VTGQERTTER LFEEEIELKW EKGGSGLVFY TDAQFWQEEE GDFDEQTADD
WDVDMSVYYD RDGGDKDARD SVQMRLERRL REGQEDGSVL GGQVGTFERH TKGIGRKVME
RQGWAEGQGL GSRCSGVPEA LDGDGQHPRC KRGLGYHGEK LQPFRQLKRP RRTGLGLIST
IYDEPLPQDQ GETLLRRQPP TSMKFRTDMT FVKGSSCALD RPEPE
