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GPV_RAT
ID   GPV_RAT                 Reviewed;         567 AA.
AC   O08770;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Platelet glycoprotein V;
DE            Short=GPV;
DE   AltName: Full=Glycoprotein 5;
DE   AltName: CD_antigen=CD42d;
DE   Flags: Precursor;
GN   Name=Gp5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Wistar; TISSUE=Liver;
RX   PubMed=9129030;
RA   Ravanat C., Morales M., Azorsa D.O., Moog S., Schuhler S., Grunert P.,
RA   Loew D., van Dorsselaer A., Cazenave J.-P., Lanza F.;
RT   "Gene cloning of rat and mouse platelet glycoprotein V: identification of
RT   megakaryocyte-specific promoters and demonstration of functional thrombin
RT   cleavage.";
RL   Blood 89:3253-3262(1997).
CC   -!- FUNCTION: The GPIb-V-IX complex functions as the vWF receptor and
CC       mediates vWF-dependent platelet adhesion to blood vessels. The adhesion
CC       of platelets to injured vascular surfaces in the arterial circulation
CC       is a critical initiating event in hemostasis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; Z69594; CAA93440.1; -; Genomic_DNA.
DR   RefSeq; NP_036927.1; NM_012795.2.
DR   AlphaFoldDB; O08770; -.
DR   SMR; O08770; -.
DR   STRING; 10116.ENSRNOP00000047810; -.
DR   GlyGen; O08770; 7 sites.
DR   iPTMnet; O08770; -.
DR   PhosphoSitePlus; O08770; -.
DR   PaxDb; O08770; -.
DR   PRIDE; O08770; -.
DR   GeneID; 25259; -.
DR   KEGG; rno:25259; -.
DR   UCSC; RGD:2724; rat.
DR   CTD; 2814; -.
DR   RGD; 2724; Gp5.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; O08770; -.
DR   OrthoDB; 826997at2759; -.
DR   PhylomeDB; O08770; -.
DR   PRO; PR:O08770; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0009986; C:cell surface; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:1990779; C:glycoprotein Ib-IX-V complex; ISO:RGD.
DR   GO; GO:0005518; F:collagen binding; ISO:RGD.
DR   GO; GO:0007596; P:blood coagulation; ISO:RGD.
DR   GO; GO:0007597; P:blood coagulation, intrinsic pathway; ISO:RGD.
DR   GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
DR   GO; GO:0035855; P:megakaryocyte development; ISO:RGD.
DR   GO; GO:0010544; P:negative regulation of platelet activation; ISO:RGD.
DR   GO; GO:0010572; P:positive regulation of platelet activation; ISO:RGD.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:RGD.
DR   Gene3D; 3.80.10.10; -; 3.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00369; LRR_TYP; 14.
DR   SMART; SM00082; LRRCT; 1.
DR   PROSITE; PS51450; LRR; 13.
PE   3: Inferred from homology;
KW   Blood coagulation; Cell adhesion; Glycoprotein; Hemostasis;
KW   Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..567
FT                   /note="Platelet glycoprotein V"
FT                   /id="PRO_0000021363"
FT   TOPO_DOM        17..522
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        523..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        544..567
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          17..50
FT                   /note="LRRNT"
FT   REPEAT          75..96
FT                   /note="LRR 1"
FT   REPEAT          99..120
FT                   /note="LRR 2"
FT   REPEAT          123..144
FT                   /note="LRR 3"
FT   REPEAT          147..168
FT                   /note="LRR 4"
FT   REPEAT          171..193
FT                   /note="LRR 5"
FT   REPEAT          195..216
FT                   /note="LRR 6"
FT   REPEAT          219..240
FT                   /note="LRR 7"
FT   REPEAT          243..264
FT                   /note="LRR 8"
FT   REPEAT          267..288
FT                   /note="LRR 9"
FT   REPEAT          291..312
FT                   /note="LRR 10"
FT   REPEAT          315..337
FT                   /note="LRR 11"
FT   REPEAT          340..361
FT                   /note="LRR 12"
FT   REPEAT          364..385
FT                   /note="LRR 13"
FT   REPEAT          388..409
FT                   /note="LRR 14"
FT   DOMAIN          421..474
FT                   /note="LRRCT"
FT   REGION          474..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        181
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        243
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        312
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        385
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        498
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   567 AA;  63345 MW;  CA10708E0D03707F CRC64;
     MLRSVLLSAV LSLVGAQPFP CPKTCKCVVR DAVQCSGGSV AHIAELGLPT NLTHILLFRM
     DRGVLQSHSF SGMTVLQRLM LSDSHISAID PGTFNDLVKL KTLRLTRNKI SHLPRAILDK
     MVLLEQLFLD HNALRDLDQN LFQKLLNLRD LCLNQNQLSF LPANLFSSLG KLKVLDLSRN
     NLTHLPQGLL GAQIKLEKLL LYSNRLMSLD SGLLANLGAL TELRLERNHL RSIAPGAFDS
     LGNLSTLTLS GNLLESLPPA LFLHVSWLTR LTLFENPLEE LPEVLFGEMA GLRELWLNGT
     HLRTLPAAAF RNLSGLQTLG LTRNPLLSAL PPGMFHGLTE LRVLAVHTNA LEELPEDALR
     GLGRLRQVSL RHNRLRALPR TLFRNLSSLV TVQLEHNQLK TLPGDVFAAL PQLTRVLLGH
     NPWLCDCGLW PFLQWLRHHL ELLGRDEPPQ CNGPESRASL TFWELLQGDQ WCPSSRGLPP
     DPPTENALKA PDPTQRPNSS QSWAWVQLVA RGESPDNRFY WNLYILLLIA QATIAGFIVF
     AMIKIGQLFR TLIREELLFE AMGKSSN
 
 
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