ID   GPWA_PSEWI              Reviewed;         222 AA.
AC   O08368;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Glutathione peroxidase;
DE            EC=1.11.1.9;
DE   Flags: Precursor;
GN   Name=gpwA;
OS   Pseudomonas wisconsinensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=57038;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LMG P-15151;
RA   Hazbon M.H., Dufel H., Cornelis P., Jaeger K.-E.;
RT   "Molecular characterization of an operon from Pseudomonas wisconsinensis
RT   responsible for the production of an extracellular lipase.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; U88907; AAB53646.1; -; Genomic_DNA.
DR   AlphaFoldDB; O08368; -.
DR   SMR; O08368; -.
DR   PeroxiBase; 3743; PwGPx01.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Periplasm; Peroxidase; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..222
FT                   /note="Glutathione peroxidase"
FT                   /id="PRO_0000013095"
FT   ACT_SITE        61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   222 AA;  24742 MW;  04A89ABC21E777CB CRC64;
     MSIRRLACSL LLSSLALPVL AAECPAMLQG ELPKLRAKGE NIELCQYAGK PLVVVNTASF
     CGFTPQFKGL EALYQRYKDQ ELEVLGVPSD DFRQESADSK ETATVCYVNY GVTFAMTEPQ
     PVSGANAIPL FKGLAEQSRQ PRWNFFKYVV DRQGKVVASF SSLTKPDDPE LIAARREGDR
     LATLIPSRFT ALHPSGRWAL SVCLPRLARR RTQFTRRALQ EQ