ID   GPX1_HELAN              Reviewed;         167 AA.
AC   O23970;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Glutathione peroxidase 1;
DE            EC=1.11.1.9;
GN   Name=GPXHA-1;
OS   Helianthus annuus (Common sunflower).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae alliance; Heliantheae; Helianthus.
OX   NCBI_TaxID=4232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Drevet J.R., Gagne G., Tourvieille de Labrouhe D., Nicolas P.,
RA   Dufaure J.-P., Ledoigt G., Roeckel-Drevet P.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May constitute a glutathione peroxidase-like protective
CC       system against oxidative stresses. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y14429; CAA74775.1; -; mRNA.
DR   PIR; T14262; T14262.
DR   AlphaFoldDB; O23970; -.
DR   SMR; O23970; -.
DR   PeroxiBase; 2652; HaGPx07.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Peroxidase.
FT   CHAIN           1..167
FT                   /note="Glutathione peroxidase 1"
FT                   /id="PRO_0000066629"
FT   ACT_SITE        41
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   167 AA;  18842 MW;  CF5AC7ACC76558C9 CRC64;
     MATQSKKTLY DFTVKDAKGN DVDLSVYKGK VVLIVNVASK CGLTNNSYDE LNQIYLKYKE
     KGFEILAFPC NQFGQQEPGT NEEIVDFVCT KFKSEFPIFD KIDVNGENAA PVYEFLKTGF
     YGILGGDIQW NFSKFLVDKN GQPVDCYYPT TSPLTVERDI QKLLGLL