ID   GPX3_CAEEL              Reviewed;         224 AA.
AC   Q95003;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Glutathione peroxidase 3;
DE            EC=1.11.1.9;
DE   Flags: Precursor;
GN   Name=gpx-3; ORFNames=C11E4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; Z81015; CAB02655.1; -; Genomic_DNA.
DR   PIR; T19190; T19190.
DR   RefSeq; NP_509616.1; NM_077215.4.
DR   AlphaFoldDB; Q95003; -.
DR   SMR; Q95003; -.
DR   STRING; 6239.C11E4.2; -.
DR   PeroxiBase; 3748; CelGPx03.
DR   PaxDb; Q95003; -.
DR   PeptideAtlas; Q95003; -.
DR   EnsemblMetazoa; C11E4.2.1; C11E4.2.1; WBGene00007517.
DR   GeneID; 182513; -.
DR   KEGG; cel:CELE_C11E4.2; -.
DR   UCSC; C11E4.2; c. elegans.
DR   CTD; 182513; -.
DR   WormBase; C11E4.2; CE08102; WBGene00007517; gpx-3.
DR   eggNOG; KOG1651; Eukaryota.
DR   GeneTree; ENSGT00970000196088; -.
DR   HOGENOM; CLU_029507_2_1_1; -.
DR   InParanoid; Q95003; -.
DR   OMA; GANEHAM; -.
DR   OrthoDB; 1483113at2759; -.
DR   PhylomeDB; Q95003; -.
DR   Reactome; R-CEL-2142712; Synthesis of 12-eicosatetraenoic acid derivatives.
DR   Reactome; R-CEL-2142770; Synthesis of 15-eicosatetraenoic acid derivatives.
DR   Reactome; R-CEL-3299685; Detoxification of Reactive Oxygen Species.
DR   PRO; PR:Q95003; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00007517; Expressed in larva and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:WormBase.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR   GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Oxidoreductase; Peroxidase; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..224
FT                   /note="Glutathione peroxidase 3"
FT                   /id="PRO_0000013090"
FT   ACT_SITE        73
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  25556 MW;  F02D055246EDE2F1 CRC64;
     MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ GEYTDLSQYR
     GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP CNQFYLQEPA ENHELMNGLT
     YVRPGNGWTP HQELHIYGKI DVNGDNHHPL YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD
     ITWNFEKFLI DRNGQPRFRF HPTAWSHGDV VTPFIEQLLA EPAN