ID   GPX6_MOUSE              Reviewed;         221 AA.
AC   Q91WR8; F2Z3U8;
DT   04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Glutathione peroxidase 6;
DE            Short=GPx-6;
DE            Short=GSHPx-6;
DE            EC=1.11.1.9;
DE   Flags: Precursor;
GN   Name=Gpx6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; AC124460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC013526; AAH13526.1; -; mRNA.
DR   CCDS; CCDS26271.1; -.
DR   RefSeq; NP_663426.2; NM_145451.3.
DR   AlphaFoldDB; Q91WR8; -.
DR   SMR; Q91WR8; -.
DR   STRING; 10090.ENSMUSP00000004453; -.
DR   PeroxiBase; 3719; MmGPx06.
DR   PhosphoSitePlus; Q91WR8; -.
DR   MaxQB; Q91WR8; -.
DR   PaxDb; Q91WR8; -.
DR   PRIDE; Q91WR8; -.
DR   ProteomicsDB; 271053; -.
DR   Antibodypedia; 6190; 40 antibodies from 15 providers.
DR   DNASU; 75512; -.
DR   Ensembl; ENSMUST00000004453; ENSMUSP00000004453; ENSMUSG00000004341.
DR   GeneID; 75512; -.
DR   KEGG; mmu:75512; -.
DR   UCSC; uc007pqa.1; mouse.
DR   CTD; 257202; -.
DR   MGI; MGI:1922762; Gpx6.
DR   VEuPathDB; HostDB:ENSMUSG00000004341; -.
DR   eggNOG; KOG1651; Eukaryota.
DR   GeneTree; ENSGT00940000161098; -.
DR   HOGENOM; CLU_029507_2_1_1; -.
DR   InParanoid; Q91WR8; -.
DR   OMA; VMRWHPR; -.
DR   OrthoDB; 1483113at2759; -.
DR   PhylomeDB; Q91WR8; -.
DR   TreeFam; TF105318; -.
DR   Reactome; R-MMU-3299685; Detoxification of Reactive Oxygen Species.
DR   BioGRID-ORCS; 75512; 3 hits in 76 CRISPR screens.
DR   ChiTaRS; Gpx7; mouse.
DR   PRO; PR:Q91WR8; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q91WR8; protein.
DR   Bgee; ENSMUSG00000004341; Expressed in olfactory epithelium and 101 other tissues.
DR   Genevisible; Q91WR8; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR   GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Peroxidase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..221
FT                   /note="Glutathione peroxidase 6"
FT                   /id="PRO_0000013082"
FT   ACT_SITE        73
FT                   /evidence="ECO:0000250"
FT   CONFLICT        52
FT                   /note="E -> G (in Ref. 2; AAH13526)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176
FT                   /note="V -> I (in Ref. 2; AAH13526)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   221 AA;  24903 MW;  39577A18B4C99BCA CRC64;
     MAQKLWGSCL FSLFMAALAQ ETLNPQKSKV DCNKGVTGTV YEYGANTIDG GEFVNFQQYA
     GKHILFVNVA SFCGLTATYP ELNTLQEELK PFNVTVLGFP CNQFGKQEPG KNSEILLGLK
     YVRPGGGYVP NFQLFEKGDV NGDNEQKVFS FLKNSCPPTS ELFGSPEHLF WDPMKVHDIR
     WNFEKFLVGP DGVPVMRWFH HTPVRIVQSD IMEYLNQTST Q