ID   GPX7_BOVIN              Reviewed;         186 AA.
AC   A6QLY2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Glutathione peroxidase 7;
DE            Short=GPx-7;
DE            Short=GSHPx-7;
DE            EC=1.11.1.9;
DE   Flags: Precursor;
GN   Name=GPX7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; BC148128; AAI48129.1; -; mRNA.
DR   RefSeq; NP_001094583.1; NM_001101113.2.
DR   AlphaFoldDB; A6QLY2; -.
DR   SMR; A6QLY2; -.
DR   STRING; 9913.ENSBTAP00000024329; -.
DR   PaxDb; A6QLY2; -.
DR   PRIDE; A6QLY2; -.
DR   Ensembl; ENSBTAT00000024329; ENSBTAP00000024329; ENSBTAG00000018281.
DR   GeneID; 523311; -.
DR   KEGG; bta:523311; -.
DR   CTD; 2882; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018281; -.
DR   VGNC; VGNC:29621; GPX7.
DR   eggNOG; KOG1651; Eukaryota.
DR   GeneTree; ENSGT00940000159127; -.
DR   HOGENOM; CLU_029507_0_1_1; -.
DR   InParanoid; A6QLY2; -.
DR   OMA; LAPFKGQ; -.
DR   OrthoDB; 1483113at2759; -.
DR   TreeFam; TF331942; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000018281; Expressed in theca cell and 106 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004096; F:catalase activity; IEA:Ensembl.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Peroxidase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..186
FT                   /note="Glutathione peroxidase 7"
FT                   /id="PRO_0000317754"
FT   ACT_SITE        56
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   186 AA;  20908 MW;  6CADF950D7A02E28 CRC64;
     MVAARAAAWL LLAAAACAPR EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV NVASECGFTD
     QHYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDSNKEIE SFARRTYSVS FPMFSKIAVT
     GTGAHPAFKY LTETSGKEPT WNFWKYLVAP DGKVIGAWDP TVSVEEIRPQ ITALVRKLIL
     KKREDL