GPX7_MOUSE
ID GPX7_MOUSE Reviewed; 186 AA.
AC Q99LJ6;
DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Glutathione peroxidase 7;
DE Short=GPx-7;
DE Short=GSHPx-7;
DE EC=1.11.1.9;
DE Flags: Precursor;
GN Name=Gpx7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: It protects esophageal epithelia from hydrogen peroxide-
CC induced oxidative stress. It suppresses acidic bile acid-induced
CC reactive oxigen species (ROS) and protects against oxidative DNA damage
CC and double-strand breaks (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000305}.
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DR EMBL; BC003228; AAH03228.1; -; mRNA.
DR CCDS; CCDS18450.1; -.
DR RefSeq; NP_077160.1; NM_024198.3.
DR AlphaFoldDB; Q99LJ6; -.
DR SMR; Q99LJ6; -.
DR BioGRID; 212090; 2.
DR STRING; 10090.ENSMUSP00000030332; -.
DR PeroxiBase; 3720; MmGPx07.
DR PhosphoSitePlus; Q99LJ6; -.
DR MaxQB; Q99LJ6; -.
DR PaxDb; Q99LJ6; -.
DR PRIDE; Q99LJ6; -.
DR ProteomicsDB; 269628; -.
DR Antibodypedia; 19147; 236 antibodies from 36 providers.
DR DNASU; 67305; -.
DR Ensembl; ENSMUST00000030332; ENSMUSP00000030332; ENSMUSG00000028597.
DR GeneID; 67305; -.
DR KEGG; mmu:67305; -.
DR UCSC; uc008ubc.1; mouse.
DR CTD; 2882; -.
DR MGI; MGI:1914555; Gpx7.
DR VEuPathDB; HostDB:ENSMUSG00000028597; -.
DR eggNOG; KOG1651; Eukaryota.
DR GeneTree; ENSGT00940000159127; -.
DR HOGENOM; CLU_029507_0_1_1; -.
DR InParanoid; Q99LJ6; -.
DR OMA; LAPFKGQ; -.
DR OrthoDB; 1483113at2759; -.
DR PhylomeDB; Q99LJ6; -.
DR TreeFam; TF331942; -.
DR Reactome; R-MMU-3299685; Detoxification of Reactive Oxygen Species.
DR BioGRID-ORCS; 67305; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Gpx7; mouse.
DR PRO; PR:Q99LJ6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q99LJ6; protein.
DR Bgee; ENSMUSG00000028597; Expressed in naris and 251 other tissues.
DR ExpressionAtlas; Q99LJ6; baseline and differential.
DR Genevisible; Q99LJ6; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004096; F:catalase activity; ISO:MGI.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004601; F:peroxidase activity; ISO:MGI.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00340; GSH_Peroxidase; 1.
DR InterPro; IPR013376; Glut_perox_Gpx7.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR029759; GPX_AS.
DR InterPro; IPR029760; GPX_CS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11592; PTHR11592; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02540; gpx7; 1.
DR PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase; Peroxidase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..186
FT /note="Glutathione peroxidase 7"
FT /id="PRO_0000013085"
FT ACT_SITE 56
FT /evidence="ECO:0000250"
SQ SEQUENCE 186 AA; 21061 MW; D20211218380A1BA CRC64;
MVAAVATAWL LLWAAACAQS EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV NVASECGFTD
QNYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDTNREIE NFARRTYSVS FPMFSKIAVT
GTGAHPAFKY LTQTSGKEPT WNFWKYLVDP DGKVVGAWDP TVPVAEIKPR ITEQVMKLIL
RKREDL
