ID   GPX8_DANRE              Reviewed;         210 AA.
AC   Q7ZV14;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Probable glutathione peroxidase 8;
DE            Short=GPx-8;
DE            Short=GSHPx-8;
DE            EC=1.11.1.9;
GN   Name=gpx8; ORFNames=zgc:56280;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Ser-80 is present instead of the conserved Cys/Sec which is
CC       expected to be the active site residue. {ECO:0000305}.
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DR   EMBL; BC046044; AAH46044.1; -; mRNA.
DR   RefSeq; NP_956516.1; NM_200222.1.
DR   AlphaFoldDB; Q7ZV14; -.
DR   SMR; Q7ZV14; -.
DR   STRING; 7955.ENSDARP00000011955; -.
DR   PaxDb; Q7ZV14; -.
DR   GeneID; 393191; -.
DR   KEGG; dre:393191; -.
DR   CTD; 493869; -.
DR   ZFIN; ZDB-GENE-040426-965; gpx8.
DR   eggNOG; KOG1651; Eukaryota.
DR   InParanoid; Q7ZV14; -.
DR   OrthoDB; 1483113at2759; -.
DR   PhylomeDB; Q7ZV14; -.
DR   Reactome; R-DRE-3299685; Detoxification of Reactive Oxygen Species.
DR   PRO; PR:Q7ZV14; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Oxidoreductase; Peroxidase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..210
FT                   /note="Probable glutathione peroxidase 8"
FT                   /id="PRO_0000317758"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23806 MW;  3973B501C27B0DA8 CRC64;
     MEALGGYPSK SSASRAGLFK VLLSVALCMG SLYLLQNKLS KSRKTKDFYS YEVKDARGRT
     VSLEKYRGKV SLVVNVASGS ELTEQSYRAL QELHRELGTS HFNVLAFPCS QYGDTESGTS
     REIEAFAKSN YGVTFPIFNK IKIMGSEAEP AFRFLTDSVQ KIPRWNFWKF LVSPEGQVVR
     FWKPEEPVSD IRKEATTLVR NIILKKRQEL