GPX8_HUMAN
ID GPX8_HUMAN Reviewed; 209 AA.
AC Q8TED1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Probable glutathione peroxidase 8;
DE Short=GPx-8;
DE Short=GSHPx-8;
DE EC=1.11.1.9;
GN Name=GPX8; ORFNames=UNQ847/PRO1785;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-182.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-182.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-182.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-182.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 44-209.
RG Structural genomics consortium (SGC);
RT "The structure of human GPX8.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC -!- INTERACTION:
CC Q8TED1; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-11721746, EBI-11522760;
CC Q8TED1; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-11721746, EBI-11957045;
CC Q8TED1; Q9BVK2: ALG8; NbExp=3; IntAct=EBI-11721746, EBI-3921603;
CC Q8TED1; P02656: APOC3; NbExp=3; IntAct=EBI-11721746, EBI-1220113;
CC Q8TED1; P05090: APOD; NbExp=3; IntAct=EBI-11721746, EBI-715495;
CC Q8TED1; P29972: AQP1; NbExp=3; IntAct=EBI-11721746, EBI-745213;
CC Q8TED1; P41181: AQP2; NbExp=3; IntAct=EBI-11721746, EBI-12701138;
CC Q8TED1; Q92482: AQP3; NbExp=3; IntAct=EBI-11721746, EBI-2808854;
CC Q8TED1; P07306: ASGR1; NbExp=3; IntAct=EBI-11721746, EBI-1172335;
CC Q8TED1; Q12797-6: ASPH; NbExp=3; IntAct=EBI-11721746, EBI-12092171;
CC Q8TED1; Q92843: BCL2L2; NbExp=3; IntAct=EBI-11721746, EBI-707714;
CC Q8TED1; O15155: BET1; NbExp=3; IntAct=EBI-11721746, EBI-749204;
CC Q8TED1; Q13323: BIK; NbExp=3; IntAct=EBI-11721746, EBI-700794;
CC Q8TED1; O95393: BMP10; NbExp=3; IntAct=EBI-11721746, EBI-3922513;
CC Q8TED1; Q12982: BNIP2; NbExp=3; IntAct=EBI-11721746, EBI-752094;
CC Q8TED1; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-11721746, EBI-8648738;
CC Q8TED1; Q06432: CACNG1; NbExp=3; IntAct=EBI-11721746, EBI-9686780;
CC Q8TED1; Q8IX05: CD302; NbExp=3; IntAct=EBI-11721746, EBI-14259393;
CC Q8TED1; P19397: CD53; NbExp=3; IntAct=EBI-11721746, EBI-6657396;
CC Q8TED1; P60033: CD81; NbExp=3; IntAct=EBI-11721746, EBI-712921;
CC Q8TED1; O14735: CDIPT; NbExp=3; IntAct=EBI-11721746, EBI-358858;
CC Q8TED1; O95674: CDS2; NbExp=3; IntAct=EBI-11721746, EBI-3913685;
CC Q8TED1; Q9BXR6: CFHR5; NbExp=3; IntAct=EBI-11721746, EBI-11579371;
CC Q8TED1; O43916: CHST1; NbExp=3; IntAct=EBI-11721746, EBI-748017;
CC Q8TED1; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-11721746, EBI-12256978;
CC Q8TED1; Q8NC01: CLEC1A; NbExp=3; IntAct=EBI-11721746, EBI-11996768;
CC Q8TED1; Q6UVW9: CLEC2A; NbExp=3; IntAct=EBI-11721746, EBI-15839595;
CC Q8TED1; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-11721746, EBI-11522780;
CC Q8TED1; O95406: CNIH1; NbExp=3; IntAct=EBI-11721746, EBI-12172273;
CC Q8TED1; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-11721746, EBI-12208021;
CC Q8TED1; P29400-2: COL4A5; NbExp=3; IntAct=EBI-11721746, EBI-12211159;
CC Q8TED1; Q4VAQ0: COL8A2; NbExp=3; IntAct=EBI-11721746, EBI-10241815;
CC Q8TED1; Q9Y5Q5: CORIN; NbExp=3; IntAct=EBI-11721746, EBI-17876114;
CC Q8TED1; P49447: CYB561; NbExp=3; IntAct=EBI-11721746, EBI-8646596;
CC Q8TED1; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-11721746, EBI-10269179;
CC Q8TED1; O14569: CYB561D2; NbExp=3; IntAct=EBI-11721746, EBI-717654;
CC Q8TED1; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-11721746, EBI-8639143;
CC Q8TED1; Q9UPQ8: DOLK; NbExp=3; IntAct=EBI-11721746, EBI-8645574;
CC Q8TED1; P56851: EDDM3B; NbExp=3; IntAct=EBI-11721746, EBI-10215665;
CC Q8TED1; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-11721746, EBI-711490;
CC Q8TED1; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-11721746, EBI-11337888;
CC Q8TED1; Q92520: FAM3C; NbExp=3; IntAct=EBI-11721746, EBI-2876774;
CC Q8TED1; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-11721746, EBI-12142299;
CC Q8TED1; O43681: GET3; NbExp=3; IntAct=EBI-11721746, EBI-2515857;
CC Q8TED1; O14653: GOSR2; NbExp=3; IntAct=EBI-11721746, EBI-4401517;
CC Q8TED1; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-11721746, EBI-11955647;
CC Q8TED1; O60883: GPR37L1; NbExp=3; IntAct=EBI-11721746, EBI-2927498;
CC Q8TED1; Q7Z429: GRINA; NbExp=3; IntAct=EBI-11721746, EBI-2832909;
CC Q8TED1; P02724: GYPA; NbExp=3; IntAct=EBI-11721746, EBI-702665;
CC Q8TED1; Q9HCP6: HHATL; NbExp=3; IntAct=EBI-11721746, EBI-5916693;
CC Q8TED1; P30519: HMOX2; NbExp=3; IntAct=EBI-11721746, EBI-712096;
CC Q8TED1; P24593: IGFBP5; NbExp=3; IntAct=EBI-11721746, EBI-720480;
CC Q8TED1; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-11721746, EBI-8503746;
CC Q8TED1; P43628: KIR2DL3; NbExp=3; IntAct=EBI-11721746, EBI-8632435;
CC Q8TED1; Q96E93: KLRG1; NbExp=3; IntAct=EBI-11721746, EBI-750770;
CC Q8TED1; Q86VI4: LAPTM4B; NbExp=3; IntAct=EBI-11721746, EBI-3267258;
CC Q8TED1; O95214: LEPROTL1; NbExp=3; IntAct=EBI-11721746, EBI-750776;
CC Q8TED1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-11721746, EBI-2820517;
CC Q8TED1; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-11721746, EBI-12133176;
CC Q8TED1; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-11721746, EBI-12033434;
CC Q8TED1; Q9Y2E5: MAN2B2; NbExp=3; IntAct=EBI-11721746, EBI-12243024;
CC Q8TED1; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-11721746, EBI-10317612;
CC Q8TED1; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-11721746, EBI-2341610;
CC Q8TED1; Q6N075: MFSD5; NbExp=3; IntAct=EBI-11721746, EBI-3920969;
CC Q8TED1; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-11721746, EBI-2858252;
CC Q8TED1; Q99735: MGST2; NbExp=3; IntAct=EBI-11721746, EBI-11324706;
CC Q8TED1; O14880: MGST3; NbExp=3; IntAct=EBI-11721746, EBI-724754;
CC Q8TED1; P30301: MIP; NbExp=3; IntAct=EBI-11721746, EBI-8449636;
CC Q8TED1; Q15546: MMD; NbExp=3; IntAct=EBI-11721746, EBI-17873222;
CC Q8TED1; A6NDP7: MYADML2; NbExp=3; IntAct=EBI-11721746, EBI-17641390;
CC Q8TED1; Q99519: NEU1; NbExp=3; IntAct=EBI-11721746, EBI-721517;
CC Q8TED1; Q92982: NINJ1; NbExp=3; IntAct=EBI-11721746, EBI-2802124;
CC Q8TED1; Q6P499: NIPAL3; NbExp=3; IntAct=EBI-11721746, EBI-10252783;
CC Q8TED1; Q16617: NKG7; NbExp=3; IntAct=EBI-11721746, EBI-3919611;
CC Q8TED1; Q8N912: NRAC; NbExp=3; IntAct=EBI-11721746, EBI-12051377;
CC Q8TED1; Q8IXM6: NRM; NbExp=3; IntAct=EBI-11721746, EBI-10262547;
CC Q8TED1; Q16625: OCLN; NbExp=3; IntAct=EBI-11721746, EBI-2903088;
CC Q8TED1; P09466: PAEP; NbExp=3; IntAct=EBI-11721746, EBI-465167;
CC Q8TED1; Q9NXK6: PAQR5; NbExp=3; IntAct=EBI-11721746, EBI-10316423;
CC Q8TED1; Q6TCH4: PAQR6; NbExp=3; IntAct=EBI-11721746, EBI-17265310;
CC Q8TED1; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-11721746, EBI-12092917;
CC Q8TED1; Q9Y342: PLLP; NbExp=3; IntAct=EBI-11721746, EBI-3919291;
CC Q8TED1; P26678: PLN; NbExp=3; IntAct=EBI-11721746, EBI-692836;
CC Q8TED1; Q04941: PLP2; NbExp=3; IntAct=EBI-11721746, EBI-608347;
CC Q8TED1; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-11721746, EBI-10485931;
CC Q8TED1; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-11721746, EBI-11721828;
CC Q8TED1; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-11721746, EBI-8652812;
CC Q8TED1; A5D903: PRB1; NbExp=3; IntAct=EBI-11721746, EBI-10173935;
CC Q8TED1; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-11721746, EBI-3232108;
CC Q8TED1; Q92730: RND1; NbExp=3; IntAct=EBI-11721746, EBI-448618;
CC Q8TED1; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-11721746, EBI-10244780;
CC Q8TED1; Q14108: SCARB2; NbExp=3; IntAct=EBI-11721746, EBI-1564650;
CC Q8TED1; Q14162: SCARF1; NbExp=3; IntAct=EBI-11721746, EBI-12056025;
CC Q8TED1; O00767: SCD; NbExp=3; IntAct=EBI-11721746, EBI-2684237;
CC Q8TED1; O75396: SEC22B; NbExp=3; IntAct=EBI-11721746, EBI-1058865;
CC Q8TED1; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-11721746, EBI-9679163;
CC Q8TED1; Q9NRX5: SERINC1; NbExp=3; IntAct=EBI-11721746, EBI-2683145;
CC Q8TED1; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-11721746, EBI-10329948;
CC Q8TED1; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-11721746, EBI-17284533;
CC Q8TED1; P11686: SFTPC; NbExp=3; IntAct=EBI-11721746, EBI-10197617;
CC Q8TED1; Q8NHU3: SGMS2; NbExp=3; IntAct=EBI-11721746, EBI-10977284;
CC Q8TED1; Q8WWT9: SLC13A3; NbExp=3; IntAct=EBI-11721746, EBI-12938720;
CC Q8TED1; Q99726: SLC30A3; NbExp=3; IntAct=EBI-11721746, EBI-10294651;
CC Q8TED1; Q8N130: SLC34A3; NbExp=3; IntAct=EBI-11721746, EBI-17769653;
CC Q8TED1; P78382: SLC35A1; NbExp=3; IntAct=EBI-11721746, EBI-12870360;
CC Q8TED1; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-11721746, EBI-10281213;
CC Q8TED1; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-11721746, EBI-10290130;
CC Q8TED1; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-11721746, EBI-10226799;
CC Q8TED1; Q6UX34: SNORC; NbExp=3; IntAct=EBI-11721746, EBI-11957067;
CC Q8TED1; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-11721746, EBI-12908338;
CC Q8TED1; Q13277: STX3; NbExp=3; IntAct=EBI-11721746, EBI-1394295;
CC Q8TED1; Q9UNK0: STX8; NbExp=3; IntAct=EBI-11721746, EBI-727240;
CC Q8TED1; Q9BQS2-2: SYT15; NbExp=3; IntAct=EBI-11721746, EBI-13373352;
CC Q8TED1; P02787: TF; NbExp=3; IntAct=EBI-11721746, EBI-714319;
CC Q8TED1; P07204: THBD; NbExp=3; IntAct=EBI-11721746, EBI-941422;
CC Q8TED1; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-11721746, EBI-6268651;
CC Q8TED1; P48230: TM4SF4; NbExp=3; IntAct=EBI-11721746, EBI-8650934;
CC Q8TED1; P55061: TMBIM6; NbExp=3; IntAct=EBI-11721746, EBI-1045825;
CC Q8TED1; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-11721746, EBI-12845616;
CC Q8TED1; Q9BVC6: TMEM109; NbExp=3; IntAct=EBI-11721746, EBI-1057733;
CC Q8TED1; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-11721746, EBI-10171534;
CC Q8TED1; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-11721746, EBI-10694905;
CC Q8TED1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-11721746, EBI-8638294;
CC Q8TED1; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-11721746, EBI-741829;
CC Q8TED1; A2RU14: TMEM218; NbExp=3; IntAct=EBI-11721746, EBI-10173151;
CC Q8TED1; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-11721746, EBI-12195227;
CC Q8TED1; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-11721746, EBI-12887458;
CC Q8TED1; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-11721746, EBI-11956809;
CC Q8TED1; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-11721746, EBI-12038591;
CC Q8TED1; P56557: TMEM50B; NbExp=3; IntAct=EBI-11721746, EBI-12366453;
CC Q8TED1; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-11721746, EBI-2852148;
CC Q8TED1; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-11721746, EBI-2548832;
CC Q8TED1; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-11721746, EBI-12111910;
CC Q8TED1; Q9NRS4: TMPRSS4; NbExp=3; IntAct=EBI-11721746, EBI-10313040;
CC Q8TED1; Q71RG4: TMUB2; NbExp=3; IntAct=EBI-11721746, EBI-2820477;
CC Q8TED1; Q8N609: TRAM1L1; NbExp=3; IntAct=EBI-11721746, EBI-11996766;
CC Q8TED1; Q86UF1: TSPAN33; NbExp=3; IntAct=EBI-11721746, EBI-12045841;
CC Q8TED1; Q53HI1: UNC50; NbExp=3; IntAct=EBI-11721746, EBI-7601760;
CC Q8TED1; O75841: UPK1B; NbExp=3; IntAct=EBI-11721746, EBI-12237619;
CC Q8TED1; Q15836: VAMP3; NbExp=3; IntAct=EBI-11721746, EBI-722343;
CC Q8TED1; O75379: VAMP4; NbExp=3; IntAct=EBI-11721746, EBI-744953;
CC Q8TED1; O95183: VAMP5; NbExp=3; IntAct=EBI-11721746, EBI-10191195;
CC Q8TED1; Q8N0U8: VKORC1L1; NbExp=3; IntAct=EBI-11721746, EBI-11337915;
CC Q8TED1; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-11721746, EBI-12190699;
CC Q8TED1; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-11721746, EBI-723716;
CC Q8TED1; O95070: YIF1A; NbExp=3; IntAct=EBI-11721746, EBI-2799703;
CC Q8TED1; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-11721746, EBI-751210;
CC Q8TED1; Q8N966: ZDHHC22; NbExp=3; IntAct=EBI-11721746, EBI-10268111;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC {ECO:0000305}.
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DR EMBL; AY358715; AAQ89077.1; -; mRNA.
DR EMBL; AK074216; BAB85019.1; -; mRNA.
DR EMBL; AC091977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471123; EAW54908.1; -; Genomic_DNA.
DR EMBL; BC029424; AAH29424.1; -; mRNA.
DR CCDS; CCDS34156.1; -.
DR RefSeq; NP_001008398.2; NM_001008397.3.
DR RefSeq; NP_001293126.1; NM_001306197.1.
DR RefSeq; NP_001293127.1; NM_001306198.1.
DR RefSeq; NP_001293130.1; NM_001306201.1.
DR PDB; 3CYN; X-ray; 2.00 A; A/B/C=44-209.
DR PDB; 3KIJ; X-ray; 1.80 A; A/B/C=38-209.
DR PDBsum; 3CYN; -.
DR PDBsum; 3KIJ; -.
DR AlphaFoldDB; Q8TED1; -.
DR SMR; Q8TED1; -.
DR BioGRID; 138926; 290.
DR IntAct; Q8TED1; 170.
DR MINT; Q8TED1; -.
DR STRING; 9606.ENSP00000423822; -.
DR DrugBank; DB09096; Benzoyl peroxide.
DR DrugBank; DB00143; Glutathione.
DR DrugBank; DB03310; Glutathione disulfide.
DR iPTMnet; Q8TED1; -.
DR PhosphoSitePlus; Q8TED1; -.
DR SwissPalm; Q8TED1; -.
DR BioMuta; GPX8; -.
DR DMDM; 269849565; -.
DR EPD; Q8TED1; -.
DR jPOST; Q8TED1; -.
DR MassIVE; Q8TED1; -.
DR MaxQB; Q8TED1; -.
DR PaxDb; Q8TED1; -.
DR PeptideAtlas; Q8TED1; -.
DR PRIDE; Q8TED1; -.
DR ProteomicsDB; 74447; -.
DR Antibodypedia; 23390; 120 antibodies from 22 providers.
DR DNASU; 493869; -.
DR Ensembl; ENST00000503787.6; ENSP00000423822.1; ENSG00000164294.14.
DR GeneID; 493869; -.
DR KEGG; hsa:493869; -.
DR MANE-Select; ENST00000503787.6; ENSP00000423822.1; NM_001008397.4; NP_001008398.2.
DR UCSC; uc003jpq.3; human.
DR CTD; 493869; -.
DR DisGeNET; 493869; -.
DR GeneCards; GPX8; -.
DR HGNC; HGNC:33100; GPX8.
DR HPA; ENSG00000164294; Low tissue specificity.
DR neXtProt; NX_Q8TED1; -.
DR OpenTargets; ENSG00000164294; -.
DR PharmGKB; PA164720300; -.
DR VEuPathDB; HostDB:ENSG00000164294; -.
DR eggNOG; KOG1651; Eukaryota.
DR GeneTree; ENSGT00940000159371; -.
DR InParanoid; Q8TED1; -.
DR OMA; KVVRFWR; -.
DR OrthoDB; 1483113at2759; -.
DR PhylomeDB; Q8TED1; -.
DR TreeFam; TF331942; -.
DR BRENDA; 1.11.1.9; 2681.
DR PathwayCommons; Q8TED1; -.
DR Reactome; R-HSA-3299685; Detoxification of Reactive Oxygen Species.
DR SignaLink; Q8TED1; -.
DR BioGRID-ORCS; 493869; 28 hits in 1075 CRISPR screens.
DR ChiTaRS; GPX8; human.
DR EvolutionaryTrace; Q8TED1; -.
DR GeneWiki; GPX8; -.
DR GenomeRNAi; 493869; -.
DR Pharos; Q8TED1; Tbio.
DR PRO; PR:Q8TED1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TED1; protein.
DR Bgee; ENSG00000164294; Expressed in stromal cell of endometrium and 160 other tissues.
DR ExpressionAtlas; Q8TED1; baseline and differential.
DR Genevisible; Q8TED1; HS.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004601; F:peroxidase activity; EXP:Reactome.
DR GO; GO:0034599; P:cellular response to oxidative stress; TAS:Reactome.
DR CDD; cd00340; GSH_Peroxidase; 1.
DR InterPro; IPR013376; Glut_perox_Gpx7.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR029760; GPX_CS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11592; PTHR11592; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02540; gpx7; 1.
DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Membrane; Oxidoreductase; Peroxidase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..209
FT /note="Probable glutathione peroxidase 8"
FT /id="PRO_0000317756"
FT TRANSMEM 18..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ACT_SITE 79
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT VARIANT 182
FT /note="K -> R (in dbSNP:rs381852)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.4"
FT /id="VAR_060456"
FT HELIX 47..49
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 51..54
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 59..61
FT /evidence="ECO:0007829|PDB:3KIJ"
FT HELIX 62..65
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:3KIJ"
FT HELIX 82..96
FT /evidence="ECO:0007829|PDB:3KIJ"
FT TURN 97..99
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 100..107
FT /evidence="ECO:0007829|PDB:3KIJ"
FT HELIX 119..130
FT /evidence="ECO:0007829|PDB:3KIJ"
FT HELIX 149..158
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 168..171
FT /evidence="ECO:0007829|PDB:3KIJ"
FT STRAND 177..181
FT /evidence="ECO:0007829|PDB:3KIJ"
FT HELIX 187..189
FT /evidence="ECO:0007829|PDB:3KIJ"
FT HELIX 191..207
FT /evidence="ECO:0007829|PDB:3KIJ"
SQ SEQUENCE 209 AA; 23881 MW; 82DACC1A85FDF6D7 CRC64;
MEPLAAYPLK CSGPRAKVFA VLLSIVLCTV TLFLLQLKFL KPKINSFYAF EVKDAKGRTV
SLEKYKGKVS LVVNVASDCQ LTDRNYLGLK ELHKEFGPSH FSVLAFPCNQ FGESEPRPSK
EVESFARKNY GVTFPIFHKI KILGSEGEPA FRFLVDSSKK EPRWNFWKYL VNPEGQVVKF
WKPEEPIEVI RPDIAALVRQ VIIKKKEDL
