ID   GPX8_TETNG              Reviewed;         210 AA.
AC   Q4RSM6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable glutathione peroxidase 8;
DE            Short=GPx-8;
DE            Short=GSHPx-8;
DE            EC=1.11.1.9;
GN   Name=gpx8; ORFNames=GSTENG00029623001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O;
CC         Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Ser-80 is present instead of the conserved Cys/Sec which is
CC       expected to be the active site residue. {ECO:0000305}.
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DR   EMBL; CAAE01014999; CAG08606.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4RSM6; -.
DR   SMR; Q4RSM6; -.
DR   STRING; 99883.ENSTNIP00000019037; -.
DR   Ensembl; ENSTNIT00000019265; ENSTNIP00000019037; ENSTNIG00000015949.
DR   KEGG; tng:GSTEN00029623G001; -.
DR   GeneTree; ENSGT00940000159371; -.
DR   HOGENOM; CLU_029507_0_1_1; -.
DR   InParanoid; Q4RSM6; -.
DR   OMA; KVVRFWR; -.
DR   TreeFam; TF331942; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Membrane; Oxidoreductase; Peroxidase; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..210
FT                   /note="Probable glutathione peroxidase 8"
FT                   /id="PRO_0000317761"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23918 MW;  40C021CC4524175C CRC64;
     MEALGGYPTR SSNPKAKKLT VLLSMTVGVG CLLLLQTQLL KPRRPSDFYS FEVKDAKGRT
     VSLEKYRGKA SLVVNVASRS EQTESNYRSL QELHRELGPS HFNVLAFPCA QFGETETGSS
     RDSEAFAKAT YGVTFPFFSR IKIMGSEAEP AFRFLTDSVQ KVPRWNFWKF LVNPEGKVVR
     FWRTDEPMES IRREVTALVR EIILKKRVEL