ID   GPXA_NEIMA              Reviewed;         177 AA.
AC   P0A0T4; A1IT29; P52036;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Glutathione peroxidase homolog;
GN   Name=gpxA; Synonyms=gph; OrderedLocusNames=NMA1820;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10722605; DOI=10.1128/iai.68.4.2082-2095.2000;
RA   Klee S.R., Nassif X., Kusecek B., Merker P., Beretti J.-L., Achtman M.,
RA   Tinsley C.R.;
RT   "Molecular and biological analysis of eight genetic islands that
RT   distinguish Neisseria meningitidis from the closely related pathogen
RT   Neisseria gonorrhoeae.";
RL   Infect. Immun. 68:2082-2095(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Important in the cellular metabolism or defense processes
CC       particular to this pathogen.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; AJ391256; CAB72011.1; -; Genomic_DNA.
DR   EMBL; AL157959; CAM08941.1; -; Genomic_DNA.
DR   PIR; C81062; C81062.
DR   RefSeq; WP_002218952.1; NC_003116.1.
DR   AlphaFoldDB; P0A0T4; -.
DR   SMR; P0A0T4; -.
DR   EnsemblBacteria; CAM08941; CAM08941; NMA1820.
DR   GeneID; 61281794; -.
DR   KEGG; nma:NMA1820; -.
DR   HOGENOM; CLU_029507_2_2_4; -.
DR   OMA; FPMMSKI; -.
DR   BioCyc; NMEN122587:NMA_RS09230-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Peroxidase.
FT   CHAIN           1..177
FT                   /note="Glutathione peroxidase homolog"
FT                   /id="PRO_0000066658"
FT   ACT_SITE        35
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  19929 MW;  89E50641FCAED5B5 CRC64;
     MGIYDFQMKD AEGNAVDLSG YRGKVLLIVN TATRCGLTPQ YEALQKLYAQ YTAEGLEILD
     FPCNQFREQA PESSGEIAQV CMMKFGTKFK IFDKIEVNGA NTAPLYAYLK SVKPQDKGNH
     LFKDFVLKLA ALGEKRDEGD IKWNFTKFLV NRDGEVVERF APSVTPEEIE ADIRALL