ID   GPXA_NEIMC              Reviewed;         177 AA.
AC   P0C2T0; P0A0T6; P52036;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Glutathione peroxidase homolog;
GN   Name=gpxA; Synonyms=gph;
OS   Neisseria meningitidis serogroup C.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=135720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FAM20 / Serogroup C;
RX   PubMed=7890429; DOI=10.1128/iai.63.4.1603-1607.1995;
RA   Moore T.D., Sparling P.F.;
RT   "Isolation and identification of a glutathione peroxidase homolog gene,
RT   gpxA, present in Neisseria meningitidis but absent in Neisseria
RT   gonorrhoeae.";
RL   Infect. Immun. 63:1603-1607(1995).
CC   -!- FUNCTION: Important in the cellular metabolism or defense processes
CC       particular to this pathogen.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000305}.
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DR   EMBL; L42112; AAA66162.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0C2T0; -.
DR   SMR; P0C2T0; -.
DR   OMA; FPMMSKI; -.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029759; GPX_AS.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Peroxidase.
FT   CHAIN           1..177
FT                   /note="Glutathione peroxidase homolog"
FT                   /id="PRO_0000066660"
FT   ACT_SITE        35
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  19929 MW;  89E50641FCAED5B5 CRC64;
     MGIYDFQMKD AEGNAVDLSG YRGKVLLIVN TATRCGLTPQ YEALQKLYAQ YTAEGLEILD
     FPCNQFREQA PESSGEIAQV CMMKFGTKFK IFDKIEVNGA NTAPLYAYLK SVKPQDKGNH
     LFKDFVLKLA ALGEKRDEGD IKWNFTKFLV NRDGEVVERF APSVTPEEIE ADIRALL