GP_SBVBH
ID GP_SBVBH Reviewed; 1403 AA.
AC H2AM12;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Envelopment polyprotein;
DE AltName: Full=M polyprotein;
DE Contains:
DE RecName: Full=Glycoprotein N {ECO:0000250|UniProtKB:P04505};
DE Short=Gn;
DE AltName: Full=Glycoprotein G2;
DE Contains:
DE RecName: Full=Non-structural protein M {ECO:0000250|UniProtKB:P04505};
DE Short=NSm;
DE Contains:
DE RecName: Full=Glycoprotein C {ECO:0000250|UniProtKB:P04505};
DE Short=Gc;
DE AltName: Full=Glycoprotein G1;
DE Flags: Precursor;
GN Name=GP;
OS Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC Schmallenberg orthobunyavirus.
OX NCBI_TaxID=1318464;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=22376991; DOI=10.3201/eid1803.111905;
RA Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H.,
RA Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A.,
RA Mettenleiter T.C., Beer M.;
RT "Novel orthobunyavirus in cattle, europe, 2011.";
RL Emerg. Infect. Dis. 18:469-472(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Hoeper D.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Germany;
RX PubMed=23326235; DOI=10.1371/journal.ppat.1003133;
RA Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M.,
RA McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M.,
RA Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.;
RT "Schmallenberg virus pathogenesis, tropism and interaction with the innate
RT immune system of the host.";
RL PLoS Pathog. 9:E1003133-E1003133(2013).
CC -!- FUNCTION: Glycoprotein C and glycoprotein N interact with each other
CC and are present at the surface of the virion. They are able to attach
CC the virion to a cell receptor and to promote fusion of membranes after
CC endocytosis of the virion (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Glycoprotein C and Glycoprotein N interact with each other.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane {ECO:0000305};
CC Single-pass type I membrane protein {ECO:0000305}. Host Golgi apparatus
CC membrane {ECO:0000305}; Single-pass type I membrane protein
CC {ECO:0000305}. Host endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass type I membrane protein {ECO:0000305}. Note=G1 alone is
CC retained in the membrane of the endoplasmic reticulum, but not
CC transported to the Golgi. Coexpression of Glycoprotein C and
CC Glycoprotein N results in efficient transport of Glycoprotein C to the
CC Golgi complex, indicating that their interaction is essential for
CC proper targeting to this organelle, where virion budding occurs (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Glycoprotein N]: Virion membrane {ECO:0000305};
CC Single-pass type I membrane protein {ECO:0000305}. Host Golgi apparatus
CC membrane {ECO:0000305}; Single-pass type I membrane protein
CC {ECO:0000305}. Note=Glycoprotein N is retained in the Golgi complex
CC through a Golgi retention signal, which resides in the Glycoprotein N
CC transmembrane region. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Non-structural protein M]: Host Golgi apparatus
CC membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- PTM: Specific enzymatic cleavages in vivo yield mature proteins
CC including nonstructural protein NSm, glycoprotein C, and glycoprotein
CC N.
CC -!- SIMILARITY: Belongs to the orthobunyavirus envelope glycoprotein
CC family. {ECO:0000305}.
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DR EMBL; JX853180; AGC84161.1; -; Viral_cRNA.
DR EMBL; HE649913; CCF55030.1; -; Genomic_RNA.
DR PDB; 6H3S; X-ray; 2.02 A; A/B=465-874.
DR PDB; 6H3T; X-ray; 2.84 A; A/B=465-702.
DR PDB; 6H3U; X-ray; 3.17 A; A/B=465-702.
DR PDB; 7A56; X-ray; 1.85 A; A=881-1306.
DR PDBsum; 6H3S; -.
DR PDBsum; 6H3T; -.
DR PDBsum; 6H3U; -.
DR PDBsum; 7A56; -.
DR SMR; H2AM12; -.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR005167; Bunya_G1.
DR InterPro; IPR005168; Bunya_G2.
DR InterPro; IPR026400; Bunya_nonstruc_pro_NSm.
DR Pfam; PF03557; Bunya_G1; 1.
DR Pfam; PF03563; Bunya_G2; 1.
DR TIGRFAMs; TIGR04210; bunya_NSm; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Fusion of virus membrane with host endosomal membrane;
KW Fusion of virus membrane with host membrane; Glycoprotein;
KW Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
KW Host-virus interaction; Membrane; Signal; Transmembrane;
KW Transmembrane helix; Viral attachment to host cell;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..1403
FT /note="Envelopment polyprotein"
FT /id="PRO_0000422470"
FT CHAIN 18..308
FT /note="Glycoprotein N"
FT /id="PRO_0000422471"
FT CHAIN 309..466
FT /note="Non-structural protein M"
FT /id="PRO_0000422472"
FT CHAIN 467..1403
FT /note="Glycoprotein C"
FT /id="PRO_0000422473"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..361
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 383..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 470..1361
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 1362..1382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1383..1403
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT STRAND 471..473
FT /evidence="ECO:0007829|PDB:6H3T"
FT HELIX 476..478
FT /evidence="ECO:0007829|PDB:6H3T"
FT HELIX 481..484
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 485..487
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 489..492
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 501..504
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 505..507
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 510..517
FT /evidence="ECO:0007829|PDB:6H3S"
FT TURN 523..525
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 526..532
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 536..549
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 551..555
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 556..558
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 559..561
FT /evidence="ECO:0007829|PDB:6H3T"
FT HELIX 563..565
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 566..574
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 578..580
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 587..594
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 598..600
FT /evidence="ECO:0007829|PDB:6H3S"
FT TURN 601..605
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 606..613
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 617..631
FT /evidence="ECO:0007829|PDB:6H3S"
FT TURN 632..634
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 638..649
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 652..655
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 656..662
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 663..665
FT /evidence="ECO:0007829|PDB:6H3S"
FT TURN 666..668
FT /evidence="ECO:0007829|PDB:6H3U"
FT HELIX 670..683
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 699..703
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 719..731
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 733..736
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 740..745
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 748..751
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 757..759
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 766..771
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 783..786
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 788..793
FT /evidence="ECO:0007829|PDB:6H3S"
FT TURN 801..803
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 806..819
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 822..829
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 834..836
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 842..844
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 847..854
FT /evidence="ECO:0007829|PDB:6H3S"
FT HELIX 866..868
FT /evidence="ECO:0007829|PDB:6H3S"
FT STRAND 887..889
FT /evidence="ECO:0007829|PDB:7A56"
FT HELIX 892..909
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 913..915
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 930..936
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 939..949
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 955..961
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 967..990
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 993..1006
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1019..1028
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1039..1052
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1056..1061
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1066..1075
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1078..1083
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1093..1100
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1109..1114
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1117..1123
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1131..1133
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1135..1139
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1142..1144
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1150..1154
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1157..1159
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1162..1169
FT /evidence="ECO:0007829|PDB:7A56"
FT HELIX 1174..1177
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1185..1187
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1194..1197
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1204..1213
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1215..1219
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1225..1234
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1242..1265
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1267..1271
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1277..1283
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1291..1295
FT /evidence="ECO:0007829|PDB:7A56"
FT STRAND 1298..1302
FT /evidence="ECO:0007829|PDB:7A56"
SQ SEQUENCE 1403 AA; 158806 MW; 90B360E3EE5BA3E5 CRC64;
MLLNIVLISN LACLAFALPL KEGTRGSRCF LNGELVKTVN TSKVVSECCV KDDISIIKSN
AEHYKSGDRL AAVIKYYRLY QVKDWHSCNP IYDDHGSFMI LDIDNTGTLI PKMHTCRVEC
EIALNKDTGE VILNSYRINH YRISGTMHVS GWFKNKIEIP LENTCESIEV TCGLKTLNFH
ACFHTHKSCT RYFKGSILPE LMIESFCTNL ELILLVTFIL VGSVMMMILT KTYIVYVFIP
IFYPFVKLYA YMYNKYFKLC KNCLLAVHPF TNCPSTCICG MIYTTTESLK LHRMCNNCSG
YKALPKTRKL CKSKISNIVL CVITSLIFFS FITPISSQCI DIEKLPDEYI TCKRELANIK
SLTIDDTYSF IYSCTCIIVL ILLKKAAKYI LYCNCSFCGM VHERRGLKIM DNFTNKCLSC
VCAENKGLTI HRASEKCLFK FESSYNRTGL IIFMLLLVPT IVMTQETSIN CKNIQSTQLT
IEHLSKCMAF YQNKTSSPVV INEIISDASV DEQELIKSLN LNCNVIDRFI SESSVIETQV
YYEYIKSQLC PLQVHDIFTI NSASNIQWKA LARSFTLGVC NTNPHKHICR CLESMQMCTS
TKTDHAREMS IYYDGHPDRF EHDMKIILNI MRYIVPGLGR VLLDQIKQTK DYQALRHIQG
KLSPKSQSNL QLKGFLEFVD FILGANVTIE KTPQTLTTLS LIKGAHRNLD QKDPGPTPIL
VCKSPQKVVC YSPRGVTHPG DYISCKSKMY KWPSLGVYKH NRDQQQACSS DTHCLEMFEP
AERTITTKIC KVSDMTYSES PYSTGIPSCN VKRFGSCNVR GHQWQIAECS NGLFYYVSAK
AHSKTNDITL YCLSANCLDL RYAFRSSSCS DIVWDTSYRN KLTPKSINHP DIENYIAALQ
SDIANDLTMH YFKPLKNLPA IIPQYKTMTL NGDKVSNGIR NSYIESHIPA INGLSAGINI
AMPNGESLFS IIIYVRRVIN KASYRFLYET GPTIGINAKH EEVCTGKCPS PIPHQDGWVT
FSKERSSNWG CEEWGCLAIN DGCLYGSCQD IIRPEYKIYK KSSIEQKDVE VCITMAHESF
CSTVDVLQPL ISDRIQLDIQ TIQMDSMPNI IAVKNGKVYV GDINDLGSTA KKCGSVQLYS
EGIIGSGTPK FDYVCHAFNR KDVILRRCFD NSYQSCLLLE QDNTLTIAST SHMEVHKKVS
SVGTINYKIM LGDFDYNAYS TQATVTIDEI RCGGCYGCPE GMACALKLST NTIGSCSIKS
NCDTYIKIIA VDPMQSEYSI KLNCPLATET VSVSVCSASA YTKPSISKNQ PKIVLNSLDE
TSYIEQHDKK CSTWLCRVYK EGISVIFQPL FGNLSFYWRL TIYIIISLIM LILFLYILIP
LCKRLKGLLE YNERIYQMEN KFK
