GQ1_HHV6U
ID GQ1_HHV6U Reviewed; 524 AA.
AC Q69572; Q69573; Q69574; Q69575; Q69576; Q76WN9;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2016, sequence version 3.
DT 02-JUN-2021, entry version 65.
DE RecName: Full=Glycoprotein Q1;
DE Short=gQ1;
DE AltName: Full=Glycoprotein 105;
DE Short=gp105;
DE AltName: Full=Glycoprotein Q-80k;
DE Short=gQ-80k;
DE AltName: Full=HCLF1 protein;
DE Flags: Precursor;
GN ORFNames=U100;
OS Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS lymphotropic virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX NCBI_TaxID=10370;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1321205; DOI=10.1099/0022-1317-73-7-1649;
RA Thomson B.J., Honess R.W.;
RT "The right end of the unique region of the genome of human herpesvirus 6
RT U1102 contains a candidate immediate early gene enhancer and a homologue of
RT the human cytomegalovirus US22 gene family.";
RL J. Gen. Virol. 73:1649-1660(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT genome evolution.";
RL Virology 209:29-51(1995).
RN [3]
RP ALTERNATIVE SPLICING (ISOFORMS GQ1 AND GQ2), AND IDENTIFICATION.
RX PubMed=7745696; DOI=10.1128/jvi.69.6.3490-3500.1995;
RA Pfeiffer B., Thomson B., Chandran B.;
RT "Identification and characterization of a cDNA derived from multiple
RT splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6.";
RL J. Virol. 69:3490-3500(1995).
RN [4]
RP CHARACTERIZATION, AND INTERACTION WITH GH AND GL.
RX PubMed=12551983; DOI=10.1128/jvi.77.4.2452-2458.2003;
RA Mori Y., Akkapaiboon P., Yang X., Yamanishi K.;
RT "The human herpesvirus 6 U100 gene product is the third component of the
RT gH-gL glycoprotein complex on the viral envelope.";
RL J. Virol. 77:2452-2458(2003).
RN [5]
RP ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, INTERACTION WITH GLYCOPROTEIN
RP Q2, AND INTERACTION WITH GH/GL.
RX PubMed=15254169; DOI=10.1128/jvi.78.15.7969-7983.2004;
RA Akkapaiboon P., Mori Y., Sadaoka T., Yonemoto S., Yamanishi K.;
RT "Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2
RT into tetrameric complexes expressed on the viral envelope.";
RL J. Virol. 78:7969-7983(2004).
RN [6]
RP FUNCTION.
RX PubMed=20863544; DOI=10.1016/j.virol.2010.08.018;
RA Tang H., Kawabata A., Yoshida M., Oyaizu H., Maeki T., Yamanishi K.,
RA Mori Y.;
RT "Human herpesvirus 6 encoded glycoprotein Q1 gene is essential for virus
RT growth.";
RL Virology 407:360-367(2010).
RN [7]
RP FUNCTION.
RX PubMed=21957287; DOI=10.1128/jvi.05622-11;
RA Kawabata A., Oyaizu H., Maeki T., Tang H., Yamanishi K., Mori Y.;
RT "Analysis of a neutralizing antibody for human herpesvirus 6B reveals a
RT role for glycoprotein Q1 in viral entry.";
RL J. Virol. 85:12962-12971(2011).
RN [8]
RP FUNCTION.
RX PubMed=23596294; DOI=10.1128/jvi.00611-13;
RA Maeki T., Hayashi M., Kawabata A., Tang H., Yamanishi K., Mori Y.;
RT "Identification of the human herpesvirus 6A gQ1 domain essential for its
RT functional conformation.";
RL J. Virol. 87:7054-7063(2013).
RN [9]
RP FUNCTION, AND SUBUNIT.
RX PubMed=24215487; DOI=10.1111/1348-0421.12110;
RA Jasirwan C., Furusawa Y., Tang H., Maeki T., Mori Y.;
RT "Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage.";
RL Microbiol. Immunol. 58:22-30(2014).
CC -!- FUNCTION: Plays a role in virus entry by participating in host receptor
CC binding at the cell surface. {ECO:0000269|PubMed:20863544,
CC ECO:0000269|PubMed:21957287, ECO:0000269|PubMed:23596294}.
CC -!- SUBUNIT: Interacts with isoform gQ2. Associates with the glycoprotein
CC complex gH-gL (PubMed:12551983, PubMed:15254169). The gH/gL/gQ1/gQ2
CC complex binds to human receptor CD46 (PubMed:24215487).
CC {ECO:0000269|PubMed:12551983, ECO:0000269|PubMed:15254169,
CC ECO:0000269|PubMed:24215487}.
CC -!- SUBCELLULAR LOCATION: Virion. Host endoplasmic reticulum lumen
CC {ECO:0000269|PubMed:15254169}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=Glycoprotein Q1 {ECO:0000303|PubMed:12551983};
CC IsoId=Q69572-1; Sequence=Displayed;
CC Name=Glycoprotein Q2 {ECO:0000303|PubMed:12551983};
CC IsoId=P0DOE0-1; Sequence=External;
CC Name=Glycoprotein Q0 {ECO:0000303|PubMed:15254169};
CC IsoId=P0DOE0-2; Sequence=External;
CC -!- PTM: Glycosylated by host. {ECO:0000269|PubMed:12551983,
CC ECO:0000269|PubMed:15254169}.
CC -!- MISCELLANEOUS: [Isoform Glycoprotein Q1]: Transcribed from a highly
CC spliced mRNA.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA01908.1; Type=Erroneous gene model prediction; Evidence={ECO:0000269|PubMed:12551983};
CC Sequence=CAA58346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000269|PubMed:12551983};
CC Sequence=CAA58347.1; Type=Erroneous gene model prediction; Evidence={ECO:0000269|PubMed:12551983};
CC Sequence=CAA58348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000269|PubMed:12551983};
CC Sequence=CAA58349.1; Type=Erroneous gene model prediction; Evidence={ECO:0000269|PubMed:12551983};
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DR EMBL; D11134; BAA01908.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X83413; CAA58346.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X83413; CAA58347.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X83413; CAA58348.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X83413; CAA58349.1; ALT_SEQ; Genomic_DNA.
DR PIR; JQ1632; JQ1632.
DR RefSeq; NP_042993.3; NC_001664.2.
DR PRIDE; Q69572; -.
DR DNASU; 1487972; -.
DR GeneID; 1487972; -.
DR KEGG; vg:1487972; -.
DR Proteomes; UP000009295; Genome.
DR GO; GO:0044166; C:host cell endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Host endoplasmic reticulum;
KW Host-virus interaction; Late protein; Reference proteome; Signal;
KW Viral attachment to host cell; Viral attachment to host entry receptor;
KW Viral envelope protein; Virion; Virus entry into host cell.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..524
FT /note="Glycoprotein Q1"
FT /evidence="ECO:0000269|PubMed:12551983"
FT /id="PRO_0000343642"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 338
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 524 AA; 59592 MW; 4BE0B38D807CA5A3 CRC64;
MATARLSAMK PPRSCALIFL CAFSMATAPT NATAHRRAGT VKSTPPPEDK HSYTAKYYDK
DIYFNIYEGR NSTPRRRTLS EIISKFSTSE MLSLKRVKAF VPVDENPTTT LEDIADILNY
AVCDDNSCGC TIETQARIMF GDIIICVPLS ADNKGVRNFK DRIMPKGLSQ ILSSSLGLHL
SLLYGAFGSN YNSLAYMRRL KPLTAMTAIR FCPMTTKLEL RQNYKVKETL CELIVSIEIL
KIRNNGGQTM KTLTSFAIVR KDNDGQDWET CTRFAPVNIE DILRYKRVAN DTCCRHRDVQ
HGRRTLESSN SWTQTQYFEP WQDIVDVYVP INDTHCPNDS YVVFETLQGF EWCSRLNKNE
TKNYLSSVLG FRNALFETEE LMETIAMRLA SQILSMVGQQ GTTIRDIDPA IVSALWHSLP
ENLTTTNIKY DIASPTHMRP ALCTIFVQTG TSKQRFRNAG LLMVNNIFTV QGRYTTQNMF
ERKEYVYKHL GQALCQGGHV FYNPKEVKSE NIKMINIKPT VVRT
