ID   GQ1_HHV6Z               Reviewed;         516 AA.
AC   Q9QJ11;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 2.
DT   02-JUN-2021, entry version 43.
DE   RecName: Full=Glycoprotein Q1;
DE            Short=gQ1;
DE   AltName: Full=Glycoprotein 105;
DE            Short=gp105;
DE   AltName: Full=Glycoprotein Q-80k;
DE            Short=gQ-80k;
DE   AltName: Full=HCLF1 protein;
DE   Flags: Precursor;
GN   ORFNames=U100;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
RN   [2]
RP   FUNCTION.
RX   PubMed=21957287; DOI=10.1128/jvi.05622-11;
RA   Kawabata A., Oyaizu H., Maeki T., Tang H., Yamanishi K., Mori Y.;
RT   "Analysis of a neutralizing antibody for human herpesvirus 6B reveals a
RT   role for glycoprotein Q1 in viral entry.";
RL   J. Virol. 85:12962-12971(2011).
RN   [3]
RP   INTERACTION WITH HOST TNFRSF4.
RX   PubMed=23674671; DOI=10.1073/pnas.1305187110;
RA   Tang H., Serada S., Kawabata A., Ota M., Hayashi E., Naka T., Yamanishi K.,
RA   Mori Y.;
RT   "CD134 is a cellular receptor specific for human herpesvirus-6B entry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:9096-9099(2013).
CC   -!- FUNCTION: Plays a role in virus entry by participating in host receptor
CC       binding at the cell surface. {ECO:0000250|UniProtKB:Q69572}.
CC   -!- SUBUNIT: Interacts with isoform gQ2. Associates with the glycoprotein
CC       complex gH-gL. The gH/gL/gQ1/gQ2 complex binds to host TNFRSF4.
CC       {ECO:0000269|PubMed:23674671}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:Q69572}. Host
CC       endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q69572}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Glycoprotein Q1;
CC         IsoId=Q9QJ11-1; Sequence=Displayed;
CC       Name=Glycoprotein Q2;
CC         IsoId=P0DOE1-1; Sequence=External;
CC       Name=Glycoprotein Q0;
CC         IsoId=P0DOE1-2; Sequence=External;
CC   -!- PTM: Glycosylated by host. {ECO:0000250|UniProtKB:Q69572}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD49680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000250|UniProtKB:Q69572};
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DR   EMBL; AF157706; AAD49680.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_050271.1; NC_000898.1.
DR   PRIDE; Q9QJ11; -.
DR   ABCD; Q9QJ11; 1 sequenced antibody.
DR   GeneID; 1497092; -.
DR   KEGG; vg:1497092; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0044166; C:host cell endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Host endoplasmic reticulum;
KW   Host-virus interaction; Late protein; Reference proteome; Signal;
KW   Viral attachment to host cell; Viral attachment to host entry receptor;
KW   Viral envelope protein; Virion; Virus entry into host cell.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..516
FT                   /note="Glycoprotein Q1"
FT                   /id="PRO_0000408406"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        330
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        351
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   516 AA;  58045 MW;  79C3EC0DA1EC8F3A CRC64;
     MRPPRRSAPI LVCAISMATA LSNATVHRDA GTVESTPPPD DEDNYTAKYY DDSIYFNIYD
     GTNPTPRRRT LPEIISKFST SEMSRLGGLK AFVPVDYTPT TTLEDIEDLL NYAICDDNSC
     GCLIETEARX MFGDIIICVP LSAESRGVRN LKSRIMPMGL SQILSSGLGL HFSLLYGAFG
     SNYNSLAYME RLKPLTAMTA IAFCPMTSKL ELRQNYRLEK ARXNLIVNIE LLKIQNHGGQ
     TIKTLTSFAI VRKDSDGQDW ETCTRFASVS IEDILRSKPA ANGTCCPPRD VHHDRPTLQS
     SNSWTRTEYF EPWQDVVDAY VPINDNHCPN DSYVVFQTLQ GHEWCSRLNK NDTKNYLSSV
     LAFKNALYET EELMETIGMR LASQILSLVG QRGTSIRNID PAIVSALWHS LPEKLTTTNI
     KYDIASPTHM SPALXTIFIQ TGTSKQRFRN AGLLMVNNIF TVQARYSKQN MFEKKIYGYE
     HLGQALCEGG HVFYNPRDVY FQNIKMAATE PTVVRT