ID   GQ2_HHV6U               Reviewed;         214 AA.
AC   P0DOE0;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Glycoprotein Q2;
DE            Short=gQ2;
DE   AltName: Full=Glycoprotein Q-37k;
DE            Short=gQ-37k;
DE   Flags: Precursor;
GN   ORFNames=U100;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1321205; DOI=10.1099/0022-1317-73-7-1649;
RA   Thomson B.J., Honess R.W.;
RT   "The right end of the unique region of the genome of human herpesvirus 6
RT   U1102 contains a candidate immediate early gene enhancer and a homologue of
RT   the human cytomegalovirus US22 gene family.";
RL   J. Gen. Virol. 73:1649-1660(1992).
RN   [2]
RP   CHARACTERIZATION, SUBCELLULAR LOCATION, AND SUBUNIT.
RC   STRAIN=GS;
RX   PubMed=15254169; DOI=10.1128/jvi.78.15.7969-7983.2004;
RA   Akkapaiboon P., Mori Y., Sadaoka T., Yonemoto S., Yamanishi K.;
RT   "Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2
RT   into tetrameric complexes expressed on the viral envelope.";
RL   J. Virol. 78:7969-7983(2004).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST CD46.
RX   PubMed=24215487; DOI=10.1111/1348-0421.12110;
RA   Jasirwan C., Furusawa Y., Tang H., Maeki T., Mori Y.;
RT   "Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage.";
RL   Microbiol. Immunol. 58:22-30(2014).
CC   -!- FUNCTION: Plays a role in virus entry by participating in host receptor
CC       binding at the cell surface. {ECO:0000269|PubMed:24215487}.
CC   -!- SUBUNIT: Interacts with isoform gQ1. Associates with the glycoprotein
CC       complex gH-gL (PubMed:15254169). The gH/gL/gQ1/gQ2 complex binds to
CC       human receptor CD46 (PubMed:24215487). {ECO:0000269|PubMed:15254169,
CC       ECO:0000269|PubMed:24215487}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane. Host endoplasmic reticulum-Golgi
CC       intermediate compartment {ECO:0000269|PubMed:15254169}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Glycoprotein Q2 {ECO:0000303|PubMed:15254169};
CC         IsoId=P0DOE0-1; Sequence=Displayed;
CC       Name=Glycoprotein Q1 {ECO:0000303|PubMed:15254169};
CC         IsoId=Q69572-1; Sequence=External;
CC       Name=Glycoprotein Q0 {ECO:0000303|PubMed:15254169};
CC         IsoId=P0DOE0-2; Sequence=Not described;
CC   -!- PTM: Glycosylated by host. {ECO:0000269|PubMed:15254169}.
CC   -!- MISCELLANEOUS: [Isoform Glycoprotein Q0]: This chain is predicted but
CC       has not been detected in HHV-6A-infected cells and virion.
CC       {ECO:0000269|PubMed:15254169}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=X83413; Type=Erroneous gene model prediction; Evidence={ECO:0000269|PubMed:15254169};
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DR   EMBL; X83413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Host-virus interaction; Late protein;
KW   Membrane; Reference proteome; Signal; Viral attachment to host cell;
KW   Viral attachment to host entry receptor; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..214
FT                   /note="Glycoprotein Q2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000438170"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        210
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   214 AA;  25121 MW;  828293200812D1F6 CRC64;
     MHFLVVYILI HFHAYRGMAA LPLFSTLPKI TSCCDSYVVI NSSTSVSSLI STCLDGEILF
     QNEGQKFCRP LTDNRTIVYT MQDQVQKPLS VTWMDFNLVI SDYGRDVINN LTKSAMLARK
     NGPRYLQMEN GPRYLQMETR ISDLFRHECY QDNYYVLDKK LQMFYPTTHS NELLFYPSEA
     TLPSPWQEPP FSSPWPEPTF PSRWYWLLLN YTNY