ID   GQ2_HHV6Z               Reviewed;         182 AA.
AC   P0DOE1;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 1.
DT   29-SEP-2021, entry version 8.
DE   RecName: Full=Glycoprotein Q2;
DE            Short=gQ2;
DE   Flags: Precursor;
GN   ORFNames=U100;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
RN   [2]
RP   INTERACTION WITH HOST TNFRSF4.
RX   PubMed=23674671; DOI=10.1073/pnas.1305187110;
RA   Tang H., Serada S., Kawabata A., Ota M., Hayashi E., Naka T., Yamanishi K.,
RA   Mori Y.;
RT   "CD134 is a cellular receptor specific for human herpesvirus-6B entry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:9096-9099(2013).
CC   -!- FUNCTION: Plays a role in virus entry by participating in host receptor
CC       binding at the cell surface. {ECO:0000250|UniProtKB:P0DOE0}.
CC   -!- SUBUNIT: Interacts with isoform gQ2. Associates with the glycoprotein
CC       complex gH-gL. The gH/gL/gQ1/gQ2 complex binds to host TNFRSF4
CC       (PubMed:23674671). {ECO:0000250|UniProtKB:P0DOE0,
CC       ECO:0000269|PubMed:23674671}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:P0DOE0}.
CC       Host endoplasmic reticulum-Golgi intermediate compartment
CC       {ECO:0000250|UniProtKB:P0DOE0}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=Glycoprotein Q2 {ECO:0000250|UniProtKB:Q69572};
CC         IsoId=P0DOE1-1; Sequence=Displayed;
CC       Name=Glycoprotein Q1 {ECO:0000250|UniProtKB:Q69572};
CC         IsoId=Q9QJ11-1; Sequence=External;
CC       Name=Glycoprotein Q0 {ECO:0000250|UniProtKB:Q69572};
CC         IsoId=P0DOE1-2; Sequence=Not described;
CC   -!- PTM: Glycosylated by host. {ECO:0000250|UniProtKB:P0DOE0}.
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DR   EMBL; AF157706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Late protein; Membrane;
KW   Reference proteome; Signal; Virion.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..182
FT                   /note="Glycoprotein Q2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000438171"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   182 AA;  21045 MW;  888B7957A780438C CRC64;
     MHFVAVYILT HFHAYPGVAA LPFFSTLPKI TSCCDHYVVL NSLSSVSSST PTCLDGEXLF
     QNAGQKFCRP FTDNRTIVYT MQDQVQRPWS VTWMDFNLVI SDYGRAVIEN LTESAMSAHK
     NGPRYLQMET FISDLFRYEC HRDNRYVLEK KLQMFYPTTH MNELLFYPSD PTLPSPYGNG
     HY