GR10A_DROME
ID GR10A_DROME Reviewed; 408 AA.
AC P58950; A1C3K6;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Gustatory receptor 10a;
GN Name=Gr10a; ORFNames=CG32664;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Oregon-R; TISSUE=Antenna;
RX PubMed=17167414; DOI=10.1038/nature05466;
RA Jones W.D., Cayirlioglu P., Grunwald Kadow I., Vosshall L.B.;
RT "Two chemosensory receptors together mediate carbon dioxide detection in
RT Drosophila.";
RL Nature 445:86-90(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11257221; DOI=10.1016/s0092-8674(01)00263-x;
RA Scott K., Brady R. Jr., Cravchik A., Morozov P., Rzhetsky A., Zuker C.,
RA Axel R.;
RT "A chemosensory gene family encoding candidate gustatory and olfactory
RT receptors in Drosophila.";
RL Cell 104:661-673(2001).
RN [5]
RP IDENTIFICATION.
RX PubMed=11516643; DOI=10.1016/s0960-9822(01)00258-5;
RA Dunipace L., Meister S., McNealy C., Amrein H.;
RT "Spatially restricted expression of candidate taste receptors in the
RT Drosophila gustatory system.";
RL Curr. Biol. 11:822-835(2001).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=22031876; DOI=10.1523/jneurosci.3363-11.2011;
RA Kwon J.Y., Dahanukar A., Weiss L.A., Carlson J.R.;
RT "Molecular and cellular organization of the taste system in the Drosophila
RT larva.";
RL J. Neurosci. 31:15300-15309(2011).
CC -!- FUNCTION: Probable gustatory receptor which mediates acceptance or
CC avoidance behavior, depending on its substrates. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the medial aspect of the third
CC antennal segment, and in neurons of the terminal external chemosensory
CC organ of larvae. {ECO:0000269|PubMed:11257221,
CC ECO:0000269|PubMed:22031876}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC receptor (GR) family. Gr10a subfamily. {ECO:0000305}.
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DR EMBL; DQ989010; ABK97611.1; -; mRNA.
DR EMBL; AE014298; AAN09631.1; -; Genomic_DNA.
DR RefSeq; NP_727523.1; NM_167283.3.
DR AlphaFoldDB; P58950; -.
DR STRING; 7227.FBpp0073394; -.
DR PaxDb; P58950; -.
DR PRIDE; P58950; -.
DR EnsemblMetazoa; FBtr0346793; FBpp0312371; FBgn0045502.
DR GeneID; 117501; -.
DR KEGG; dme:Dmel_CG32664; -.
DR CTD; 117501; -.
DR FlyBase; FBgn0045502; Gr10a.
DR VEuPathDB; VectorBase:FBgn0045502; -.
DR eggNOG; ENOG502T8FD; Eukaryota.
DR HOGENOM; CLU_055520_0_0_1; -.
DR InParanoid; P58950; -.
DR OMA; HQFQLLG; -.
DR PhylomeDB; P58950; -.
DR BioGRID-ORCS; 117501; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 117501; -.
DR PRO; PR:P58950; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0045502; Expressed in olfactory receptor neuron (Drosophila) and 2 other tissues.
DR Genevisible; P58950; DM.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033041; F:sweet taste receptor activity; IBA:GO_Central.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0050909; P:sensory perception of taste; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR013604; 7TM_chemorcpt.
DR PANTHER; PTHR21143; PTHR21143; 1.
DR Pfam; PF08395; 7tm_7; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..408
FT /note="Gustatory receptor 10a"
FT /id="PRO_0000216490"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 21..38
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..48
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..144
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 271..291
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..304
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 305..325
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 382..402
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..408
FT /note="Extracellular"
FT /evidence="ECO:0000250"
SQ SEQUENCE 408 AA; 48392 MW; 63FEBB27DDE856AD CRC64;
MTSPDERKSF WERHEFKFYR YGHVYALIYG QVVIDYVPQR ALKRGVKVLL IAYGHLFSML
LIVVLPGYFC YHFRTLTDTL DRRLQLLFYV SFTNTAIKYA TVIVTYVANT VHFEAINQRC
TMQRTHLEFE FKNAPQEPKR PFEFFMYFKF CLINLMMMIQ VCGIFAQYGE VGKGSVSQVR
VHFAIYAFVL WNYTENMADY CYFINGSVLK YYRQFNLQLG SLRDEMDGLR PGGMLLHHCC
ELSDRLEELR RRCREIHDLQ RESFRMHQFQ LIGLMLSTLI NNLTNFYTLF HMLAKQSLEE
VSYPVVVGSV YATGFYIDTY IVALINEHIK LELEAVALTM RRFAEPREMD ERLTREIEHL
SLELLNYQPP MLCGLLHLDR RLVYLIAVTA FSYFITLVQF DLYLRKKS
