GR1_ARATH
ID GR1_ARATH Reviewed; 588 AA.
AC Q9ZRT1; A9NJH0; Q9SUZ3;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Protein gamma response 1;
DE AltName: Full=COM1/SAE2-like protein;
DE AltName: Full=Protein gamma response I;
GN Name=GR1; OrderedLocusNames=At3g52115; ORFNames=F4F15.230;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=11023598; DOI=10.1667/0033-7587(2000)154[0355:mcadeo]2.0.co;2;
RA Deveaux Y., Alonso B., Pierrugues O., Godon C., Kazmaier M.;
RT "Molecular cloning and developmental expression of AtGR1, a new growth-
RT related Arabidopsis gene strongly induced by ionizing radiation.";
RL Radiat. Res. 154:355-364(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pedrosa-Harand A., Siwiec T., Uanschou C., Kerzendorfer C.,
RA Sanchez-Moran E., Novatchkova M., Akimcheva S., Klein F., Schlogelhofer P.;
RT "The COM1/SAE2 homolog of Arabidopsis thaliana: identification and
RT characterization of a DNA repair protein essential for meiosis.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Seems to mediate cell cycle arrest before mitosis in response
CC to DNA damage. Is probably also involved in the transition from mitosis
CC to endoreduplication. {ECO:0000269|PubMed:11023598}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Basal levels in mitotically dividing cells
CC (meristems), and high levels in endoreduplicating cells (stipules,
CC trichomes) (at protein level). {ECO:0000269|PubMed:11023598}.
CC -!- INDUCTION: Strongly induced by ionizing radiation in a dose-dependent
CC way. Regulated by ATM in response to DNA double strand breaks (DSBs)
CC (at protein level). {ECO:0000269|PubMed:11023598}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41332.1; Type=Erroneous gene model prediction; Note=The predicted gene At3g52120 has been split into 2 genes: At3g52115 and At3g52120.; Evidence={ECO:0000305};
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DR EMBL; AJ131708; CAA10484.1; -; Genomic_DNA.
DR EMBL; DQ925470; ABI95360.1; -; mRNA.
DR EMBL; AL049711; CAB41332.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78895.1; -; Genomic_DNA.
DR PIR; T48905; T48905.
DR PIR; T49091; T49091.
DR RefSeq; NP_850683.1; NM_180352.3.
DR AlphaFoldDB; Q9ZRT1; -.
DR SMR; Q9ZRT1; -.
DR STRING; 3702.AT3G52115.1; -.
DR iPTMnet; Q9ZRT1; -.
DR PaxDb; Q9ZRT1; -.
DR PRIDE; Q9ZRT1; -.
DR ProteomicsDB; 220650; -.
DR EnsemblPlants; AT3G52115.1; AT3G52115.1; AT3G52115.
DR GeneID; 824375; -.
DR Gramene; AT3G52115.1; AT3G52115.1; AT3G52115.
DR KEGG; ath:AT3G52115; -.
DR Araport; AT3G52115; -.
DR TAIR; locus:1005716561; AT3G52115.
DR eggNOG; KOG0965; Eukaryota.
DR HOGENOM; CLU_026815_0_0_1; -.
DR InParanoid; Q9ZRT1; -.
DR OMA; QIELLFC; -.
DR OrthoDB; 629980at2759; -.
DR PhylomeDB; Q9ZRT1; -.
DR PRO; PR:Q9ZRT1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9ZRT1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0000406; F:double-strand/single-strand DNA junction binding; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0070336; F:flap-structured DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0000403; F:Y-form DNA binding; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:TAIR.
DR GO; GO:0010792; P:DNA double-strand break processing involved in repair via single-strand annealing; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0007276; P:gamete generation; IMP:TAIR.
DR GO; GO:0010212; P:response to ionizing radiation; IEP:TAIR.
DR InterPro; IPR013882; Ctp1_C.
DR InterPro; IPR033316; RBBP8-like.
DR PANTHER; PTHR15107; PTHR15107; 1.
DR Pfam; PF08573; SAE2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA damage; Nucleus; Reference proteome.
FT CHAIN 1..588
FT /note="Protein gamma response 1"
FT /id="PRO_0000076223"
FT REGION 377..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..104
FT /evidence="ECO:0000255"
FT COILED 164..281
FT /evidence="ECO:0000255"
FT COMPBIAS 446..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 14..15
FT /note="IS -> NL (in Ref. 1; CAA10484)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="A -> R (in Ref. 1; CAA10484)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="E -> EE (in Ref. 1; CAA10484)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 588 AA; 67231 MW; 65080791E83CDEFC CRC64;
MGDETVDGIE AKYISGLSTI MVATIQEAKD RISQIEYIFC SQLFPNFQSK SKAFEKVYSE
ARLAACDTWK DREKSLLDQI EELKVENQQI KSDKEKLAEE LGKTASMPLR LTSLQGYIDH
LKKKMKSRSK MVGDARDLYY RLVELLQVKG LDELSEDGIN MIVSEVKSLK MKTEFLQEEL
SKKTLVTENL LKKLEYLSTE AADGERKLSS VEEEKQRLKT RLQVFEENVG RLEEILRQKT
DEVEEGKTAL EVLQGKLKLT EREMLNCKQK IADHEKEKTV VMGKAKDDMQ GRHGSYLADL
EALRCQSEEK SFELAMEIKK NKELSRTCKK WKSQHTFLCK RFNFTPDSVL HQSSLEDENK
EIGQHEKSAI SSYLERKHSE TAEGADKVRI GTGSSGNNYE KESIIKTVQT PITSISPIVR
SPGAAKPPQL SGLKRPASIW RDTRSRQSPG GHDPHDDFLD TPIENVKRVA GEEKHVHDVA
KKDDSDDETQ DMNPKPSPSR QRIQIAETSK KSFKHVESVR KKAERENLKG IECKQCKKFY
DAVHPENEGN GNKSLRCEHH EGVSRHRYRY APPMTPEGFW NIGFESEM
