GR22_ANOGA
ID GR22_ANOGA Reviewed; 467 AA.
AC Q7PMG3; A1C3K7;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Gustatory and odorant receptor 22;
GN Name=GPRgr22 {ECO:0000312|EMBL:ABK97612.1}; ORFNames=AGAP009999;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABK97612.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=G3 {ECO:0000312|EMBL:ABK97612.1};
RC TISSUE=Head {ECO:0000312|EMBL:ABK97612.1};
RX PubMed=17167414; DOI=10.1038/nature05466;
RA Jones W.D., Cayirlioglu P., Grunwald Kadow I., Vosshall L.B.;
RT "Two chemosensory receptors together mediate carbon dioxide detection in
RT Drosophila.";
RL Nature 445:86-90(2007).
RN [2] {ECO:0000312|EMBL:EAA13882.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000312|EMBL:EAA13882.2};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Gustatory receptor which mediates acceptance or avoidance
CC behavior, depending on its substrates. GPRgr22 and GPRgr24 together are
CC sufficient for olfactory carbon dioxide-chemosensation.
CC {ECO:0000269|PubMed:17167414}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Carbon dioxide-responsive neurons coexpress GPRgr22
CC and GPRgr24 in the maxillary palp at both larval and adult life stages.
CC {ECO:0000269|PubMed:17167414}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC receptor (GR) family. Gr21a subfamily. {ECO:0000305}.
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DR EMBL; DQ989011; ABK97612.1; -; mRNA.
DR EMBL; AAAB01008980; EAA13882.2; -; Genomic_DNA.
DR RefSeq; XP_319142.1; XM_319142.3.
DR AlphaFoldDB; Q7PMG3; -.
DR SMR; Q7PMG3; -.
DR STRING; 7165.AGAP009999-PA; -.
DR PaxDb; Q7PMG3; -.
DR PRIDE; Q7PMG3; -.
DR GeneID; 1279425; -.
DR KEGG; aga:AgaP_AGAP009999; -.
DR CTD; 1279425; -.
DR VEuPathDB; VectorBase:AGAP009999; -.
DR eggNOG; ENOG502R7M7; Eukaryota.
DR HOGENOM; CLU_049090_0_0_1; -.
DR InParanoid; Q7PMG3; -.
DR OMA; FYHTTKS; -.
DR OrthoDB; 809607at2759; -.
DR PhylomeDB; Q7PMG3; -.
DR Proteomes; UP000007062; Chromosome 3R.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004984; F:olfactory receptor activity; IMP:UniProtKB.
DR GO; GO:0008527; F:taste receptor activity; IMP:UniProtKB.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0010037; P:response to carbon dioxide; IMP:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; IMP:UniProtKB.
DR GO; GO:0050909; P:sensory perception of taste; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR013604; 7TM_chemorcpt.
DR PANTHER; PTHR21143; PTHR21143; 1.
DR Pfam; PF08395; 7tm_7; 1.
PE 2: Evidence at transcript level;
KW Behavior; Cell membrane; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..467
FT /note="Gustatory and odorant receptor 22"
FT /id="PRO_0000296317"
FT TOPO_DOM 1..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 107..127
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..144
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 145..165
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 199..219
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 239..259
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 305..325
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..337
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 338..358
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 415..435
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..467
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 54183 MW; 20285C3C254EEF6A CRC64;
MIHTQMEDAQ YEIRHQVLNP NQRQQLEDRR RIKEQLHQLE QDNESPTHMY RRKLKIASDV
NLLDQHDSFY HTTKSLLVLF QIMGVMPIMR SPKGVDMPRT TFTWCSKAFL WAYFIYACET
VIVLVVARER INKFISTSDK RFDEVIYNII FMSIMVPHFL LPVASWRNGS EVAKFKNMWT
DFQYKYLIVT GKPIVFPKLY PITWTLCIVS WSLSLVIILS QYYLQPDFQF CHTFAYYHII
AMLNGFCSLW FVNCTAFGTA SKAFAKELTD VLATERPAAK LTEYRHLWVD LSHMMQQLGK
AYSNMYGIYC LVIFFTTIIA TYGSLSEIIE HGATYKEVGL FVIVFYCMSL LFIICNEAHH
ASKRVGLNFQ ERLLNVNLTA VDKATQKEVE MFLVAIDKNP PTMNLDGYAN INRGLITSNI
SFMATYLVVL MQFKLTLLRQ SAKNAFISAL KANLSRIRSL DADKVNT
