GR24_ANOGA
ID GR24_ANOGA Reviewed; 457 AA.
AC Q7PYF4; A1C3K9;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 4.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Gustatory and odorant receptor 24;
GN Name=GPRgr24 {ECO:0000312|EMBL:ABK97614.1}; ORFNames=AGAP001915;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:ABK97614.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 80-457, FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=G3 {ECO:0000312|EMBL:ABK97614.1};
RC TISSUE=Head {ECO:0000312|EMBL:ABK97614.1};
RX PubMed=17167414; DOI=10.1038/nature05466;
RA Jones W.D., Cayirlioglu P., Grunwald Kadow I., Vosshall L.B.;
RT "Two chemosensory receptors together mediate carbon dioxide detection in
RT Drosophila.";
RL Nature 445:86-90(2007).
CC -!- FUNCTION: Gustatory receptor which mediates acceptance or avoidance
CC behavior, depending on its substrates. GPRgr22 and GPRgr24 together are
CC sufficient for olfactory carbon dioxide-chemosensation.
CC {ECO:0000269|PubMed:17167414}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Carbon dioxide-responsive neurons coexpress GPRgr22
CC and GPRgr24 in the maxillary palp, at both larval and adult life
CC stages. {ECO:0000269|PubMed:17167414}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC receptor (GR) family. Gr21a subfamily. {ECO:0000305}.
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DR EMBL; AAAB01008987; EAA01019.4; -; Genomic_DNA.
DR EMBL; DQ989013; ABK97614.1; -; mRNA.
DR RefSeq; XP_321150.4; XM_321150.5.
DR AlphaFoldDB; Q7PYF4; -.
DR STRING; 7165.AGAP001915-PA; -.
DR PaxDb; Q7PYF4; -.
DR GeneID; 1281211; -.
DR KEGG; aga:AgaP_AGAP001915; -.
DR CTD; 1281211; -.
DR VEuPathDB; VectorBase:AGAP001915; -.
DR eggNOG; ENOG502SPS2; Eukaryota.
DR HOGENOM; CLU_049090_0_0_1; -.
DR InParanoid; Q7PYF4; -.
DR OMA; ALCYTFV; -.
DR OrthoDB; 809607at2759; -.
DR PhylomeDB; Q7PYF4; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004984; F:olfactory receptor activity; IMP:UniProtKB.
DR GO; GO:0008527; F:taste receptor activity; IMP:UniProtKB.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0010037; P:response to carbon dioxide; IMP:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; IMP:UniProtKB.
DR GO; GO:0050909; P:sensory perception of taste; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR013604; 7TM_chemorcpt.
DR PANTHER; PTHR21143; PTHR21143; 1.
DR Pfam; PF08395; 7tm_7; 1.
PE 2: Evidence at transcript level;
KW Behavior; Cell membrane; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..457
FT /note="Gustatory and odorant receptor 24"
FT /id="PRO_0000296318"
FT TOPO_DOM 1..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 116..136
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..152
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 153..173
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 210..230
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..237
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 238..258
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 310..330
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..341
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 342..362
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..421
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 422..442
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..457
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 196
FT /note="T -> S (in Ref. 2; ABK97614)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 457 AA; 51736 MW; DE4A271B147F1847 CRC64;
MSLYFNADTM RIERSSVHEP KRNRNVFLDV KPIADDANVN VPPRQAARRN ATVFNNRVGF
PPLTPKEAFV DAVPADQTCM VFESSKPIYL VLRAIGVLPY TRLPSGGTAF VLASPSMTYC
VLFFLLLTVY IAFILLNRIE IVRTLEGRFE ESVIAYLFIV NILPILIIPL MWYESRKVVS
VVNGWVDFET VYRETTGRAL ELRLRTKAQV IAILLPILCS LSVAITHVTM VDFKLLQVIP
YCVLDTITYM MGGYWYMACE TLSITAKILA EDFQRALRHV GPAAKVSEYR SLWLRLSKLA
RDTGFSTCYT FTFICLYLFF IITLSIYGLM SQISDGFGVK DIGLAVTAFC SVGLLFYICD
EAHYASFNVR TNFQKKLLMV ELSWMNTDAQ TEINMFLRAT EMNPSSINLG GFFDVNRTLF
KSLLATMVTY LVVLLQFQIS IPDEPSAMLM HSNSSHS
