GR39B_DROME
ID GR39B_DROME Reviewed; 369 AA.
AC P58960;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Putative gustatory receptor 39b;
GN Name=Gr39b; Synonyms=GR39D.1; ORFNames=CG31620;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=10710312; DOI=10.1126/science.287.5459.1830;
RA Clyne P.J., Warr C.G., Carlson J.R.;
RT "Candidate taste receptors in Drosophila.";
RL Science 287:1830-1834(2000).
RN [4]
RP IDENTIFICATION.
RX PubMed=11516643; DOI=10.1016/s0960-9822(01)00258-5;
RA Dunipace L., Meister S., McNealy C., Amrein H.;
RT "Spatially restricted expression of candidate taste receptors in the
RT Drosophila gustatory system.";
RL Curr. Biol. 11:822-835(2001).
RN [5]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=21870111; DOI=10.1007/s10059-011-0128-1;
RA Park J.H., Kwon J.Y.;
RT "A systematic analysis of Drosophila gustatory receptor gene expression in
RT abdominal neurons which project to the central nervous system.";
RL Mol. Cells 32:375-381(2011).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=22031876; DOI=10.1523/jneurosci.3363-11.2011;
RA Kwon J.Y., Dahanukar A., Weiss L.A., Carlson J.R.;
RT "Molecular and cellular organization of the taste system in the Drosophila
RT larva.";
RL J. Neurosci. 31:15300-15309(2011).
CC -!- FUNCTION: Probable gustatory receptor which mediates acceptance or
CC avoidance behavior, depending on its substrates (By similarity). Has
CC also atypical sensory function in organ not limited to conventional
CC taste sensing like abdominal ganglions. {ECO:0000250,
CC ECO:0000269|PubMed:21870111}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the adult labellar chemosensory
CC neurons and in abdominal ganglions. In larvae, is expressed in neurons
CC of the dorsal and posterior pharyngeal sense organs.
CC {ECO:0000269|PubMed:10710312, ECO:0000269|PubMed:21870111,
CC ECO:0000269|PubMed:22031876}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC receptor (GR) family. Gr2a subfamily. {ECO:0000305}.
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DR EMBL; AE014134; AAN11120.1; -; Genomic_DNA.
DR RefSeq; NP_724336.1; NM_165376.1.
DR AlphaFoldDB; P58960; -.
DR STRING; 7227.FBpp0081050; -.
DR PaxDb; P58960; -.
DR EnsemblMetazoa; FBtr0081522; FBpp0081050; FBgn0041245.
DR GeneID; 117347; -.
DR KEGG; dme:Dmel_CG31620; -.
DR CTD; 117347; -.
DR FlyBase; FBgn0041245; Gr39b.
DR VEuPathDB; VectorBase:FBgn0041245; -.
DR eggNOG; ENOG502T3DC; Eukaryota.
DR HOGENOM; CLU_062916_0_0_1; -.
DR InParanoid; P58960; -.
DR OMA; GWSILSI; -.
DR OrthoDB; 1039185at2759; -.
DR PhylomeDB; P58960; -.
DR BioGRID-ORCS; 117347; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 117347; -.
DR PRO; PR:P58960; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0041245; Expressed in testis.
DR Genevisible; P58960; DM.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008527; F:taste receptor activity; ISS:FlyBase.
DR GO; GO:0050909; P:sensory perception of taste; ISS:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR013604; 7TM_chemorcpt.
DR PANTHER; PTHR21143; PTHR21143; 1.
DR Pfam; PF08395; 7tm_7; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..369
FT /note="Putative gustatory receptor 39b"
FT /id="PRO_0000216513"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..59
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 123..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..147
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 225..245
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..265
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 266..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 349..368
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369
FT /note="Extracellular"
FT /evidence="ECO:0000250"
SQ SEQUENCE 369 AA; 42334 MW; C31B3E88B0721758 CRC64;
MLYSFHPYLK YFALLGLVPW SESCAQSKFV QKVYSAILII LNAVHFGISI YFPQSAELFL
SLMVNVIVFV ARIVCVTVII LQVMVHYDDY FRFCREMKYL GLRLQCELKI HVGRLKWQSY
AKILALGIGF LVTVLPSIYV ALSGSLLYFW SSLLSILIIR MQFVLVLLNV ELLGHHVSLL
GIRLQNVLEC HLMGANCTLD GNANRLCSLE FLLALKQSHM QLHYLFTHFN DLFGWSILGT
YVVLFSDSTV NIYWTQQVLV EVYEYKYLYA TFSVFVPSFF NILVFCRCGE FCQRQSVLIG
SYLRNLSCHP SIGRETSYKD LLMEFILQVE QNVLAINAEG FMSTDNSLLM SILAAKVTYL
IVLMQFSSV
