GR77A_DROME
ID GR77A_DROME Reviewed; 449 AA.
AC Q8IPU5;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Putative gustatory receptor 77a;
GN Name=Gr77a; Synonyms=GR77E.1; ORFNames=CG32433;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAN12140.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=10710312; DOI=10.1126/science.287.5459.1830;
RA Clyne P.J., Warr C.G., Carlson J.R.;
RT "Candidate taste receptors in Drosophila.";
RL Science 287:1830-1834(2000).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=11516643; DOI=10.1016/s0960-9822(01)00258-5;
RA Dunipace L., Meister S., McNealy C., Amrein H.;
RT "Spatially restricted expression of candidate taste receptors in the
RT Drosophila gustatory system.";
RL Curr. Biol. 11:822-835(2001).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=22031876; DOI=10.1523/jneurosci.3363-11.2011;
RA Kwon J.Y., Dahanukar A., Weiss L.A., Carlson J.R.;
RT "Molecular and cellular organization of the taste system in the Drosophila
RT larva.";
RL J. Neurosci. 31:15300-15309(2011).
CC -!- FUNCTION: Probable gustatory receptor which mediates acceptance or
CC avoidance behavior, depending on its substrates. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In larvae, is expressed in dorsal pharyngeal sense
CC organ. {ECO:0000269|PubMed:22031876}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily. Gustatory
CC receptor (GR) family. Gr77a subfamily. {ECO:0000305}.
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DR EMBL; AE014296; AAN12140.1; -; Genomic_DNA.
DR RefSeq; NP_730560.1; NM_168868.2.
DR AlphaFoldDB; Q8IPU5; -.
DR STRING; 7227.FBpp0077939; -.
DR PaxDb; Q8IPU5; -.
DR EnsemblMetazoa; FBtr0078281; FBpp0077939; FBgn0045474.
DR GeneID; 117476; -.
DR KEGG; dme:Dmel_CG32433; -.
DR CTD; 117476; -.
DR FlyBase; FBgn0045474; Gr77a.
DR VEuPathDB; VectorBase:FBgn0045474; -.
DR eggNOG; ENOG502T3Q4; Eukaryota.
DR HOGENOM; CLU_687483_0_0_1; -.
DR InParanoid; Q8IPU5; -.
DR OMA; IFVGCFS; -.
DR OrthoDB; 844720at2759; -.
DR PhylomeDB; Q8IPU5; -.
DR BioGRID-ORCS; 117476; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 117476; -.
DR PRO; PR:Q8IPU5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0045474; Expressed in saliva-secreting gland and 6 other tissues.
DR ExpressionAtlas; Q8IPU5; baseline and differential.
DR Genevisible; Q8IPU5; DM.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0050909; P:sensory perception of taste; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR013604; 7TM_chemorcpt.
DR PANTHER; PTHR21143; PTHR21143; 1.
DR Pfam; PF08395; 7tm_7; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..449
FT /note="Putative gustatory receptor 77a"
FT /id="PRO_0000216537"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 28..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..70
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 71..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 103..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..205
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 206..228
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 299..321
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..340
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 341..363
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 421..443
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 444..449
FT /note="Extracellular"
FT /evidence="ECO:0000250"
SQ SEQUENCE 449 AA; 51955 MW; 30021608F44BDFC1 CRC64;
MPLPLGDPLA LAVSPQLGYI RITAMPRWLQ LPGMSALGIL YSLTRVFGLM ATANWSPRGI
KRVRQSLYLR IHGCVMLIFV GCFSPFAFWC IFQRMAFLRQ NRILLMIGFN RYVLLLVCAF
MTLWIHCFKQ AEIIGCLNRL LKCRRRLRRL MHTRKLKDSM DCLATKGHLL EVVVLLSSYL
LSMAQPIQIL KDDPEVRRNF MYACSLVFVS VCQAILQLSL GMYTMAILFL GHLVRHSNLL
LAKILADAEH IFESSQKAGF WPNRQELYKG QQKWLALELW RLLHVHHQLL KLHRSICSLC
AVQAVCFLGF VPLECTIHLF FTYFMKYSKF ILRKYGRSFP LNYFAIAFLV GLFTNLLLVI
LPTYYSERRF NCTREIIKGG GLAFPSRITV KQLRHTMHFY GLYLKNVEHV FAVSACGLFK
LNNAILFCIV GAILEYLMIL IQFDKVLNK
