GRA7_TOXGO
ID GRA7_TOXGO Reviewed; 236 AA.
AC O00933;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Dense granule protein 7;
DE Short=Protein GRA 7;
DE AltName: Full=29 kDa excretory dense granule protein;
DE AltName: Full=p29;
DE Flags: Precursor;
GN Name=GRA7;
OS Toxoplasma gondii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=5811;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=BK;
RX PubMed=9566518; DOI=10.1016/s0166-6851(97)00227-2;
RA Fischer H.-G., Stachelhaus S., Sahm M., Meyer H.E., Reichmann G.;
RT "GRA7, an excretory 29 kDa Toxoplasma gondii dense granule antigen released
RT by infected host cells.";
RL Mol. Biochem. Parasitol. 91:251-262(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wiktor;
RX PubMed=9566517; DOI=10.1016/s0166-6851(97)00204-1;
RA Jacobs D., Dubremetz J.-F., Loyens A., Bosman F., Saman E.;
RT "Identification and heterologous expression of a new dense granule protein
RT (GRA7) from Toxoplasma gondii.";
RL Mol. Biochem. Parasitol. 91:237-249(1998).
CC -!- SUBCELLULAR LOCATION: Secreted. Parasitophorous vacuole lumen.
CC Parasitophorous vacuole membrane. Cytoplasmic vesicle, secretory
CC vesicle. Note=Located in dense granules of tachyzoites. Upon infection,
CC secreted into the parasitophorous vacuole (PV).
CC -!- SIMILARITY: Belongs to the Gra7 family. {ECO:0000305}.
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DR EMBL; Y13863; CAA74178.1; -; Genomic_DNA.
DR EMBL; U79158; AAC48314.1; -; mRNA.
DR AlphaFoldDB; O00933; -.
DR VEuPathDB; ToxoDB:TGARI_203310; -.
DR VEuPathDB; ToxoDB:TGCAST_203310; -.
DR VEuPathDB; ToxoDB:TGCOUG_203310; -.
DR VEuPathDB; ToxoDB:TGDOM2_203310; -.
DR VEuPathDB; ToxoDB:TGFOU_203310; -.
DR VEuPathDB; ToxoDB:TGGT1_203310; -.
DR VEuPathDB; ToxoDB:TGMAS_203310; -.
DR VEuPathDB; ToxoDB:TGME49_203310; -.
DR VEuPathDB; ToxoDB:TGP89_203310; -.
DR VEuPathDB; ToxoDB:TGPRC2_203310; -.
DR VEuPathDB; ToxoDB:TGRH88_035710; -.
DR VEuPathDB; ToxoDB:TGRUB_203310; -.
DR VEuPathDB; ToxoDB:TGVAND_203310; -.
DR VEuPathDB; ToxoDB:TGVEG_203310; -.
DR PHI-base; PHI:4049; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020005; C:symbiont-containing vacuole membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR InterPro; IPR008120; Dense_granule_Gra7_protein.
DR PRINTS; PR01747; DENSEGRNULE7.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Direct protein sequencing; Glycoprotein; Membrane;
KW Secreted; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..236
FT /note="Dense granule protein 7"
FT /id="PRO_0000021371"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 45..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 236 AA; 25858 MW; 1E3304C23A1E8516 CRC64;
MARHAIFSAL CVLGLVAAAL PQFATAATAS DDELMSRIRN SDFFDGQAPV DSLRPTNAGV
DSKGTDDHLT TSMDKASVES QLPRREPLET EPDEQEEVHF RKRGVRSDAE VTDDNIYEEH
TDRKVVPRKS EGKRSFKDLL KKLALPAVGM GASYFAADRL VPELTEEQQR GDEPLTTGQN
VGTVLGFAAL AAAAAFLGMG LTRTYRHFSP RKNRSRQPAL EQEVPESGED GEDARQ
