位置:首页 > 蛋白库 > GRAF_GRASX
GRAF_GRASX
ID   GRAF_GRASX              Reviewed;          25 AA.
AC   P69835;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Grammistin Gs F;
DE   AltName: Full=Gs 1;
OS   Grammistes sexlineatus (Goldenstriped soapfish) (Perca sexlineata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Serranoidei; Serranidae; Epinephelinae;
OC   Grammistini; Grammistes.
OX   NCBI_TaxID=270576;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND TOXIC DOSE.
RC   TISSUE=Skin secretion;
RX   PubMed=10669014; DOI=10.1016/s0041-0101(99)00136-1;
RA   Shiomi K., Igarashi T., Yokota H., Nagashima Y., Ishida M.;
RT   "Isolation and structures of grammistins, peptide toxins from the skin
RT   secretion of the soapfish Grammistes sexlineatus.";
RL   Toxicon 38:91-103(2000).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=15777955; DOI=10.1016/j.toxicon.2004.12.021;
RA   Sugiyama N., Araki M., Ishida M., Nagashima Y., Shiomi K.;
RT   "Further isolation and characterization of grammistins from the skin
RT   secretion of the soapfish Grammistes sexlineatus.";
RL   Toxicon 45:595-601(2005).
RN   [3]
RP   FUNCTION.
RX   DOI=10.1046/j.1444-2906.2001.00343.x;
RA   Yokota H., Nagashima Y., Shiomi K.;
RT   "Interaction of grammistins with lipids and their antibacterial activity.";
RL   Fish. Sci. 67:928-933(2001).
CC   -!- FUNCTION: Thanks to its abundant amphiphilic alpha-helices, it may
CC       integrate into membrane phospholipids, leading to lysis of the
CC       membrane. Its hemolytic activity is inhibited by phospholipids, but not
CC       by cholesterol. Has antibacterial activity with a broad spectrum
CC       against various species of bacteria including both Gram-positive and
CC       Gram-negative groups. Has also ichthyotoxic activity.
CC       {ECO:0000269|Ref.3}.
CC   -!- SUBUNIT: Exists as aggregates of 3-4 molecules. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- MASS SPECTROMETRY: Mass=2792; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10669014};
CC   -!- TOXIC DOSE: LD(50) is 1.9 ug/ml against killifish.
CC   -!- SIMILARITY: Belongs to the grammistin family. Group 1 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P69835; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Secreted; Toxin.
FT   PEPTIDE         1..25
FT                   /note="Grammistin Gs F"
FT                   /id="PRO_0000044518"
SQ   SEQUENCE   25 AA;  2789 MW;  5F1414052A607E40 CRC64;
     LFGFLIKLIP SLFGALSNIG RNRNQ
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024