GRAPL_HUMAN
ID GRAPL_HUMAN Reviewed; 118 AA.
AC Q8TC17; B2RXI8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=GRB2-related adapter protein-like;
GN Name=GRAPL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 53-118 (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TC17; O43741: PRKAB2; NbExp=3; IntAct=EBI-18300553, EBI-1053424;
CC Q8TC17; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-18300553, EBI-10226430;
CC Q8TC17; Q8WWU5-7: TCP11; NbExp=3; IntAct=EBI-18300553, EBI-17721485;
CC Q8TC17; P36508: ZNF76; NbExp=3; IntAct=EBI-18300553, EBI-7254550;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TC17-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TC17-2; Sequence=VSP_039172;
CC -!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026233; AAH26233.1; -; mRNA.
DR EMBL; BC157869; AAI57870.1; -; mRNA.
DR CCDS; CCDS45627.1; -. [Q8TC17-1]
DR RefSeq; NP_001123250.1; NM_001129778.1. [Q8TC17-1]
DR RefSeq; XP_016880126.1; XM_017024637.1. [Q8TC17-1]
DR AlphaFoldDB; Q8TC17; -.
DR SMR; Q8TC17; -.
DR BioGRID; 134647; 5.
DR IntAct; Q8TC17; 4.
DR STRING; 9606.ENSP00000437409; -.
DR iPTMnet; Q8TC17; -.
DR PhosphoSitePlus; Q8TC17; -.
DR BioMuta; GRAPL; -.
DR DMDM; 296439331; -.
DR jPOST; Q8TC17; -.
DR MassIVE; Q8TC17; -.
DR MaxQB; Q8TC17; -.
DR PaxDb; Q8TC17; -.
DR PeptideAtlas; Q8TC17; -.
DR PRIDE; Q8TC17; -.
DR ProteomicsDB; 74071; -. [Q8TC17-1]
DR ProteomicsDB; 74072; -. [Q8TC17-2]
DR Antibodypedia; 63469; 4 antibodies from 4 providers.
DR DNASU; 400581; -.
DR Ensembl; ENST00000344415.9; ENSP00000437409.2; ENSG00000189152.11. [Q8TC17-1]
DR GeneID; 400581; -.
DR KEGG; hsa:400581; -.
DR MANE-Select; ENST00000344415.9; ENSP00000437409.2; NM_001129778.3; NP_001123250.1.
DR UCSC; uc010cqk.2; human. [Q8TC17-1]
DR CTD; 400581; -.
DR GeneCards; GRAPL; -.
DR HGNC; HGNC:37240; GRAPL.
DR HPA; ENSG00000189152; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q8TC17; -.
DR OpenTargets; ENSG00000189152; -.
DR PharmGKB; PA165431929; -.
DR VEuPathDB; HostDB:ENSG00000189152; -.
DR eggNOG; KOG3601; Eukaryota.
DR GeneTree; ENSGT00940000156254; -.
DR InParanoid; Q8TC17; -.
DR OMA; WANAERD; -.
DR OrthoDB; 1091250at2759; -.
DR PhylomeDB; Q8TC17; -.
DR TreeFam; TF354288; -.
DR PathwayCommons; Q8TC17; -.
DR SignaLink; Q8TC17; -.
DR BioGRID-ORCS; 400581; 12 hits in 642 CRISPR screens.
DR ChiTaRS; GRAPL; human.
DR GenomeRNAi; 400581; -.
DR Pharos; Q8TC17; Tdark.
DR PRO; PR:Q8TC17; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8TC17; protein.
DR Bgee; ENSG00000189152; Expressed in spleen and 93 other tissues.
DR ExpressionAtlas; Q8TC17; baseline and differential.
DR Genevisible; Q8TC17; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd11948; SH3_GRAP_N; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR035645; GRAP_N_SH3.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037; PTHR46037; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; SH2 domain; SH3 domain.
FT CHAIN 1..118
FT /note="GRB2-related adapter protein-like"
FT /id="PRO_0000344236"
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 60..118
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 89..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 100..102
FT /note="NNR -> K (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039172"
SQ SEQUENCE 118 AA; 13442 MW; 15CCFC3347AA8ABE CRC64;
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW
YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN NRAQRGPCLG PKSHSRLG
