ID   GRAR_GLARU              Reviewed;          12 AA.
AC   P40754;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   02-DEC-2020, entry version 45.
DE   RecName: Full=Granuliberin-R;
OS   Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Glandirana.
OX   NCBI_TaxID=8410;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT SER-12.
RC   TISSUE=Skin secretion;
RX   PubMed=589733; DOI=10.1248/cpb.25.2464;
RA   Nakajima T., Yasuhara T.;
RT   "A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana
RT   rugosa) skin.";
RL   Chem. Pharm. Bull. 25:2464-2465(1977).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=657408; DOI=10.1248/cpb.26.1222;
RA   Nakajima T., Yasuhara T., Hirai Y., Kitada C., Fujino M., Takeyama M.,
RA   Koyama K., Yajima H.;
RT   "Synthesis of the dodecapeptide amide corresponding to the entire amino
RT   acid sequence of granuliberin-R, a new frog skin peptide from Rana
RT   rugosa.";
RL   Chem. Pharm. Bull. 26:1222-1230(1978).
CC   -!- FUNCTION: Mast cell degranulating peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Mast cell degranulation; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Granuliberin-R"
FT                   /id="PRO_0000043802"
FT   MOD_RES         12
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000269|PubMed:589733"
SQ   SEQUENCE   12 AA;  1424 MW;  2B974EB9CA1B5047 CRC64;
     FGFLPIYRRP AS