ID   GRAX_STAA8              Reviewed;         307 AA.
AC   Q2G0E1;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Auxiliary protein GraX;
GN   Name=graX; OrderedLocusNames=SAOUHSC_00664;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION.
RX   PubMed=21765893; DOI=10.1371/journal.pone.0021323;
RA   Falord M., Maeder U., Hiron A., Debarbouille M., Msadek T.;
RT   "Investigation of the Staphylococcus aureus GraSR regulon reveals novel
RT   links to virulence, stress response and cell wall signal transduction
RT   pathways.";
RL   PLoS ONE 6:E21323-E21323(2011).
RN   [3]
RP   FUNCTION, INTERACTION WITH GRAR AND GRAS, AND SUBUNIT.
RX   PubMed=25685323; DOI=10.12688/f1000research.5512.2;
RA   Muzamal U., Gomez D., Kapadia F., Golemi-Kotra D.;
RT   "Diversity of two-component systems: insights into the signal transduction
RT   mechanism by the Staphylococcus aureus two-component system GraSR.";
RL   F1000Research 3:252-252(2014).
CC   -!- FUNCTION: Plays a role in resistance against cationic antimicrobial
CC       peptides (CAMPs) (PubMed:25685323, PubMed:21765893). Facilitates the
CC       activation of GraS to transduce the signal to GraR (PubMed:25685323).
CC       {ECO:0000269|PubMed:21765893, ECO:0000269|PubMed:25685323}.
CC   -!- SUBUNIT: Homodimer (PubMed:25685323). Interacts with GraR and GraS
CC       (PubMed:25685323). {ECO:0000269|PubMed:25685323}.
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DR   EMBL; CP000253; ABD29797.1; -; Genomic_DNA.
DR   RefSeq; WP_000802946.1; NZ_LS483365.1.
DR   RefSeq; YP_499223.1; NC_007795.1.
DR   AlphaFoldDB; Q2G0E1; -.
DR   SMR; Q2G0E1; -.
DR   STRING; 1280.SAXN108_0725; -.
DR   EnsemblBacteria; ABD29797; ABD29797; SAOUHSC_00664.
DR   GeneID; 3919954; -.
DR   KEGG; sao:SAOUHSC_00664; -.
DR   PATRIC; fig|93061.5.peg.595; -.
DR   eggNOG; COG0451; Bacteria.
DR   HOGENOM; CLU_079605_0_0_9; -.
DR   OMA; DCRIKHF; -.
DR   Proteomes; UP000008816; Chromosome.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..307
FT                   /note="Auxiliary protein GraX"
FT                   /id="PRO_0000448699"
SQ   SEQUENCE   307 AA;  35235 MW;  E4DD9A76B0860F45 CRC64;
     MKPKVLLAGG TGYIGKYLSE VIENDAELFA ISKYPDNKKT DDVEMTWIQC DIFHYEQVVA
     AMNQIDIAVF FIDPTKNSAK ITQSSARDLT LIAADNFGRA AAINQVKKVI YIPGSRYDNE
     TIERLGAYGT PVETTNLVFK RSLVNVELQV SKYDDVRSTM KVVLPKGWTL KNVVNHFIAW
     MGYTKGTFVK TEKSHDQFKI YIKNKVRPLA VFKIEETADG IITLILLSGS LVKKYTVNQG
     KLEFRLIKES AVVYIHLYDY IPRLFWPIYY FIQAPMQKMM IHGFEVDCRI KDFQSRLKSG
     ENMKYTK