GRB2_CHICK
ID GRB2_CHICK Reviewed; 217 AA.
AC Q07883;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Growth factor receptor-bound protein 2;
DE AltName: Full=Adapter protein GRB2;
DE AltName: Full=SH2/SH3 adapter GRB2;
GN Name=GRB2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8262390; DOI=10.1016/0378-1119(93)90111-f;
RA Wasenius V.-M., Merilainen J., Lehto V.-P.;
RT "Sequence of a chicken cDNA encoding a GRB2 protein.";
RL Gene 134:299-300(1993).
RN [2]
RP INTERACTION WITH LAT2.
RX PubMed=15539154; DOI=10.1016/j.immuni.2004.09.007;
RA Stork B., Engelke M., Frey J., Horejsi V., Hamm-Baarke A., Schraven B.,
RA Kurosaki T., Wienands J.;
RT "Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-
RT regulating signal circuit in B lymphocytes.";
RL Immunity 21:681-691(2004).
CC -!- FUNCTION: Adapter protein that provides a critical link between cell
CC surface growth factor receptors and the Ras signaling pathway.
CC {ECO:0000250}.
CC -!- SUBUNIT: Associates with activated Tyr-phosphorylated EGF receptors and
CC PDGF receptors via its SH2 domain. Also associates to other cellular
CC Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably
CC via the concerted action of both its SH2 and SH3 domains. It also seems
CC to interact with RAS in the signaling pathway leading to DNA synthesis.
CC Binds to and translocates the guanine nucleotide exchange factors SOS
CC (By similarity). Interacts with phosphorylated LAT2. {ECO:0000250,
CC ECO:0000269|PubMed:15539154}.
CC -!- INTERACTION:
CC Q07883; Q7L591: DOK3; Xeno; NbExp=3; IntAct=EBI-7061573, EBI-2834978;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Endosome {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
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DR EMBL; L19258; AAA16318.1; -; mRNA.
DR PIR; JT0664; JT0664.
DR RefSeq; NP_989742.1; NM_204411.1.
DR AlphaFoldDB; Q07883; -.
DR BMRB; Q07883; -.
DR SMR; Q07883; -.
DR IntAct; Q07883; 2.
DR MINT; Q07883; -.
DR STRING; 9031.ENSGALP00000012993; -.
DR PaxDb; Q07883; -.
DR GeneID; 386572; -.
DR KEGG; gga:386572; -.
DR CTD; 2885; -.
DR VEuPathDB; HostDB:geneid_386572; -.
DR eggNOG; KOG3601; Eukaryota.
DR InParanoid; Q07883; -.
DR OrthoDB; 1091250at2759; -.
DR PhylomeDB; Q07883; -.
DR PRO; PR:Q07883; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd11949; SH3_GRB2_C; 1.
DR CDD; cd11946; SH3_GRB2_N; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR035643; GRB2_C_SH3.
DR InterPro; IPR035641; GRB2_N_SH3.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SSF50044; 2.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Endosome; Golgi apparatus; Nucleus; Reference proteome; Repeat;
KW SH2 domain; SH3 domain.
FT CHAIN 1..217
FT /note="Growth factor receptor-bound protein 2"
FT /id="PRO_0000088202"
FT DOMAIN 1..58
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 60..152
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 156..215
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
SQ SEQUENCE 217 AA; 25076 MW; DDC9A84ECDC52859 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKGGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQQFKV LRDGAGKYLL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EEGELGFRRG
DFIQVLDNSD PNWWKGACHG QTGMFPRNYV TPVNRNI
