GRB2_XENTR
ID GRB2_XENTR Reviewed; 229 AA.
AC Q66II3;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Growth factor receptor-bound protein 2;
DE AltName: Full=Adapter protein GRB2;
DE AltName: Full=SH2/SH3 adapter GRB2;
GN Name=grb2 {ECO:0000312|EMBL:AAH81338.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAH81338.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH81338.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein that provides a critical link between cell
CC surface growth factor receptors and the Ras signaling pathway. Promotes
CC meiotic reinitiation during oocyte maturation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Endosome {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC -!- DOMAIN: The two SH3 domains and the SH2 domain are necessary for the
CC reinitiation of oocyte meiosis. {ECO:0000250|UniProtKB:P87379}.
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DR EMBL; BC081338; AAH81338.1; -; mRNA.
DR RefSeq; NP_001008130.1; NM_001008129.1.
DR RefSeq; XP_012827139.1; XM_012971685.2.
DR RefSeq; XP_012827140.1; XM_012971686.2.
DR RefSeq; XP_012827141.1; XM_012971687.2.
DR RefSeq; XP_012827142.1; XM_012971688.2.
DR AlphaFoldDB; Q66II3; -.
DR SMR; Q66II3; -.
DR STRING; 8364.ENSXETP00000027387; -.
DR PaxDb; Q66II3; -.
DR DNASU; 493492; -.
DR Ensembl; ENSXETT00000027387; ENSXETP00000027387; ENSXETG00000012520.
DR GeneID; 493492; -.
DR KEGG; xtr:493492; -.
DR CTD; 2885; -.
DR Xenbase; XB-GENE-6070000; grb2.
DR eggNOG; KOG3601; Eukaryota.
DR HOGENOM; CLU_073617_1_0_1; -.
DR InParanoid; Q66II3; -.
DR OMA; DFSLSVX; -.
DR OrthoDB; 1091250at2759; -.
DR PhylomeDB; Q66II3; -.
DR TreeFam; TF354288; -.
DR Reactome; R-XTR-109704; PI3K Cascade.
DR Reactome; R-XTR-112412; SOS-mediated signalling.
DR Reactome; R-XTR-1250347; SHC1 events in ERBB4 signaling.
DR Reactome; R-XTR-1257604; PIP3 activates AKT signaling.
DR Reactome; R-XTR-1295596; Spry regulation of FGF signaling.
DR Reactome; R-XTR-1433557; Signaling by SCF-KIT.
DR Reactome; R-XTR-1433559; Regulation of KIT signaling.
DR Reactome; R-XTR-167044; Signalling to RAS.
DR Reactome; R-XTR-179812; GRB2 events in EGFR signaling.
DR Reactome; R-XTR-180336; SHC1 events in EGFR signaling.
DR Reactome; R-XTR-182971; EGFR downregulation.
DR Reactome; R-XTR-186763; Downstream signal transduction.
DR Reactome; R-XTR-1963640; GRB2 events in ERBB2 signaling.
DR Reactome; R-XTR-1963642; PI3K events in ERBB2 signaling.
DR Reactome; R-XTR-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-XTR-210993; Tie2 Signaling.
DR Reactome; R-XTR-2179392; EGFR Transactivation by Gastrin.
DR Reactome; R-XTR-2424491; DAP12 signaling.
DR Reactome; R-XTR-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-XTR-2871796; FCERI mediated MAPK activation.
DR Reactome; R-XTR-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-XTR-375165; NCAM signaling for neurite out-growth.
DR Reactome; R-XTR-388841; Costimulation by the CD28 family.
DR Reactome; R-XTR-389359; CD28 dependent Vav1 pathway.
DR Reactome; R-XTR-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-XTR-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-XTR-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-XTR-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-XTR-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-XTR-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-XTR-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-XTR-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-XTR-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-XTR-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-XTR-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-XTR-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-XTR-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-XTR-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-XTR-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-XTR-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-XTR-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-XTR-5673001; RAF/MAP kinase cascade.
DR Reactome; R-XTR-6807004; Negative regulation of MET activity.
DR Reactome; R-XTR-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-XTR-74749; Signal attenuation.
DR Reactome; R-XTR-74751; Insulin receptor signalling cascade.
DR Reactome; R-XTR-8851805; MET activates RAS signaling.
DR Reactome; R-XTR-8851907; MET activates PI3K/AKT signaling.
DR Reactome; R-XTR-8853659; RET signaling.
DR Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-XTR-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-XTR-8865999; MET activates PTPN11.
DR Reactome; R-XTR-8875555; MET activates RAP1 and RAC1.
DR Reactome; R-XTR-8875656; MET receptor recycling.
DR Reactome; R-XTR-9027284; Erythropoietin activates RAS.
DR Reactome; R-XTR-912631; Regulation of signaling by CBL.
DR Reactome; R-XTR-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000012520; Expressed in brain and 14 other tissues.
DR GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd11949; SH3_GRB2_C; 1.
DR CDD; cd11946; SH3_GRB2_N; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR030219; Grb2.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR035643; GRB2_C_SH3.
DR InterPro; IPR035641; GRB2_N_SH3.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037; PTHR46037; 1.
DR PANTHER; PTHR46037:SF4; PTHR46037:SF4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SSF50044; 2.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Endosome; Golgi apparatus; Meiosis;
KW Nucleus; Reference proteome; Repeat; SH2 domain; SH3 domain.
FT CHAIN 1..229
FT /note="Growth factor receptor-bound protein 2"
FT /id="PRO_0000088205"
FT DOMAIN 1..58
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 60..171
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 168..227
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
SQ SEQUENCE 229 AA; 26422 MW; ACC0DCFC344F154B CRC64;
MEAVAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQVHGG DRATNLLQQP TYVQALFDFD
PQEDGELGFR RGDFIQVVDN SDPNWWKGTC LGQTGMFPRN YVTPVNRNM
