ID   GRC12_ARATH             Reviewed;         103 AA.
AC   O82254; C1JGP6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Putative glutaredoxin-C12;
DE            Short=AtGrxC12;
DE   AltName: Full=Protein ROXY 5;
GN   Name=GRXC12; Synonyms=ROXY5; OrderedLocusNames=At2g47870;
GN   ORFNames=F17A22.26, T9J23.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND GENE FAMILY.
RX   PubMed=19218396; DOI=10.1105/tpc.108.064477;
RA   Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.;
RT   "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is
RT   required for petal development in Arabidopsis thaliana.";
RL   Plant Cell 21:429-441(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15170506; DOI=10.1007/s00018-004-3410-y;
RA   Rouhier N., Gelhaye E., Jacquot J.-P.;
RT   "Plant glutaredoxins: still mysterious reducing systems.";
RL   Cell. Mol. Life Sci. 61:1266-1277(2004).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=16720602; DOI=10.1093/jxb/erl001;
RA   Rouhier N., Couturier J., Jacquot J.-P.;
RT   "Genome-wide analysis of plant glutaredoxin systems.";
RL   J. Exp. Bot. 57:1685-1696(2006).
CC   -!- FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the
CC       presence of NADPH and glutathione reductase. Reduces low molecular
CC       weight disulfides and proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glutaredoxin family. CC-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; FJ611905; ACO50410.1; -; mRNA.
DR   EMBL; AC005309; AAC63641.1; -; Genomic_DNA.
DR   EMBL; AC006072; AAM15125.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10903.1; -; Genomic_DNA.
DR   PIR; E84920; E84920.
DR   RefSeq; NP_001318444.1; NM_001337281.1.
DR   AlphaFoldDB; O82254; -.
DR   SMR; O82254; -.
DR   BioGRID; 4734; 1.
DR   STRING; 3702.AT2G47870.1; -.
DR   PaxDb; O82254; -.
DR   PRIDE; O82254; -.
DR   EnsemblPlants; AT2G47870.1; AT2G47870.1; AT2G47870.
DR   GeneID; 28718362; -.
DR   Gramene; AT2G47870.1; AT2G47870.1; AT2G47870.
DR   KEGG; ath:AT2G47870; -.
DR   Araport; AT2G47870; -.
DR   TAIR; locus:2043408; AT2G47870.
DR   eggNOG; KOG1752; Eukaryota.
DR   HOGENOM; CLU_026126_6_0_1; -.
DR   InParanoid; O82254; -.
DR   OMA; HDANGRE; -.
DR   OrthoDB; 1535999at2759; -.
DR   PhylomeDB; O82254; -.
DR   PRO; PR:O82254; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O82254; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:TAIR.
DR   InterPro; IPR011905; GlrX-like_pln_2.
DR   InterPro; IPR002109; Glutaredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR10168; PTHR10168; 1.
DR   Pfam; PF00462; Glutaredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02189; GlrX-like_plant; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..103
FT                   /note="Putative glutaredoxin-C12"
FT                   /id="PRO_0000268719"
FT   DOMAIN          1..102
FT                   /note="Glutaredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT   DISULFID        21..24
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  11261 MW;  EEB894E33E8DC3BF CRC64;
     MERVRDLASE KAAVIFTKSS CCMCHSIKTL FYELGASPAI HELDKDPQGP DMERALFRVF
     GSNPAVPAVF VGGRYVGSAK DVISFHVDGS LKQMLKASNA IWL