ID   GRC3_ASPCL              Reviewed;         839 AA.
AC   A1CFB5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Polynucleotide 5'-hydroxyl-kinase grc3;
DE            EC=2.7.1.-;
GN   Name=grc3; ORFNames=ACLA_092620;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS027052; EAW11564.1; -; Genomic_DNA.
DR   RefSeq; XP_001272990.1; XM_001272989.1.
DR   AlphaFoldDB; A1CFB5; -.
DR   SMR; A1CFB5; -.
DR   STRING; 5057.CADACLAP00008381; -.
DR   EnsemblFungi; EAW11564; EAW11564; ACLA_092620.
DR   GeneID; 4705247; -.
DR   KEGG; act:ACLA_092620; -.
DR   VEuPathDB; FungiDB:ACLA_092620; -.
DR   eggNOG; KOG2750; Eukaryota.
DR   HOGENOM; CLU_010345_1_2_1; -.
DR   OMA; PLYQRIW; -.
DR   OrthoDB; 1217334at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; Transferase.
FT   CHAIN           1..839
FT                   /note="Polynucleotide 5'-hydroxyl-kinase grc3"
FT                   /id="PRO_0000289951"
FT   REGION          1..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..784
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          807..839
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..131
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         333..340
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   839 AA;  91913 MW;  912E6E1C7DC65C0D CRC64;
     MKRKAEKQQA AAPVSAFAAR KARQQQAQVV PSEKPATNEL STEPPSKKPR RSLEEGAANL
     TANGEDHVQT RRSSRRKQES LRSGVSDEKQ HKKAALNVRT RSAAQPPAQK DEEKDLSGAL
     EEEDDEEVLE EENDAGAIAL DGDADGYESP VDVAHLQNFP LSKTRLNKNS VIYSDEQTLC
     VRIKEKMNLV LLGHYDLWVK RGVVSLMGAK LHPSARVYRV YAPSTHSLPV IKCIAGVDGE
     AEIEVKSCHS GIYRLRHLSP LYQRIWNGKN TSADRLTLKK APASAKRTFS VLYTSSDDSL
     NRHLRPLHLE KQWSSAIKSL SQRNGQLRVL ICGPKASGKS TFSRYLLNHL LSPAPQTETD
     FRNTDGVAFL DLDPGQPEFS PMGQVYLAHL GSPFFGPPFT HPSLDGGQDG SIIRAHHIGA
     TSPKDDPDHY VLAAMDLMDR YRSLLASYPQ CPLIINYPGW IFGLGLEVAT WLVKSLGLSD
     VVYMSEKGPA EVVEPLSQAA YEARIPLTTL PSQPTDFVSR SSAQLRSMQI QSYFHMSQPS
     EIQTPQWLET TISKSRPFVV DYAGPRQGIR GIMVMGSQIS PDLLHDVLDG AIVGVVAVES
     PNAIMTGESE QPPSEPAMDE GNSQSDGDMS DVASDVAMED GPASPSTKTA HTTPASPSFE
     TMITRTSGED LPYLFVGAGS CNPLDPKASN CLGLALVRSI DVPSRKLELV TPIPGLKIRE
     ALEQGHGIVL VRGMLDNPNW ALSEDYYAAR AAEKGHQQSV AKAKKDTGAG EDGDAAATSD
     QQPTVSAMLR DRIRRASNVP WMTVIEDNSR RHREAAQREK SLWKLRKKAY PGSESETDW